CAS 18444-66-1
:Cucurbitacina E
Descripción:
Cucurbitacina E es un compuesto triterpenoide derivado principalmente de varias plantas de la familia Cucurbitaceae, como los pepinos y las calabazas. Es conocido por su sabor amargo y se ha estudiado por sus posibles propiedades farmacológicas, incluyendo efectos anti-cancerígenos, anti-inflamatorios y anti-diabéticos. La estructura molecular de Cucurbitacina E presenta un marco tetracíclico, que es característico de los cucurbitacinos, contribuyendo a su actividad biológica. Este compuesto exhibe una variedad de actividades biológicas, incluyendo la capacidad de inhibir la proliferación celular e inducir apoptosis en ciertas líneas celulares cancerosas. Además, se ha investigado Cucurbitacina E por sus efectos en varias vías de señalización, como las vías NF-κB y MAPK, que son cruciales en la inflamación y la progresión del cáncer. Debido a sus potentes efectos biológicos, Cucurbitacina E es de interés en la química medicinal y la investigación de productos naturales, aunque su sabor amargo y la posible toxicidad a altas dosis requieren una cuidadosa consideración en las aplicaciones terapéuticas.
Fórmula:C32H44O8
InChI:InChI=1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1
Clave InChI:InChIKey=NDYMQXYDSVBNLL-MUYMLXPFSA-N
SMILES:C[C@]12[C@@](C)([C@@]([C@@](C(/C=C/C(OC(C)=O)(C)C)=O)(C)O)([C@H](O)C1)[H])CC(=O)[C@]3(C)[C@]2(CC=C4[C@]3(C=C(O)C(=O)C4(C)C)[H])[H]
Sinónimos:- (23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-2,5,23-trien-25-yl acetate
- (4R,9beta,16alpha,23E)-2,16,20-trihydroxy-9,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-2,5,23-trien-25-yl acetate
- (9β,10α,16α,23E)-25-(Acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
- 18444-66-1
- 19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione, 2,16α,20,25-tetrahydroxy-9-methyl-, 25-acetate
- 19-Norlanosta-1,5,23-triene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (9β,10α,16α,23E)-
- 2,16,20-Trihydroxy-9,10,14-Trimethyl-1,11,22-Trioxo-4,9-Cyclo-9,10-Secocholesta-2,5,23-Trien-25-Yl Acetate
- Cucurbitacine E
- NSC 106399
- NSC 521775
- [(E)-5-[(8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-5-hydroxy-1,1-dimethyl-4-oxo-hex-2-enyl] acetate
- cucurbitacin E
- α-Elaterin
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Se han encontrado 13 productos.
Cucurbitacin E (Standard)
CAS:Cucurbitacin E (Standard) is a reference standard for research and analysis in studies involving Cucurbitacin E. Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplastic, anti-inflammatory and analgesic actions.Fórmula:C32H44O8Peso molecular:556.69Cucurbitacin E
CAS:Cucurbitacin E analytical standard provided with w/w absolute assay, to be used for quantitative titration.Fórmula:C32H44O8Pureza:(HPLC) ≥95%Forma y color:PowderPeso molecular:556.7Cucurbitacin E
CAS:Fórmula:C32H44O8Pureza:≥ 98.0%Forma y color:White to beige powderPeso molecular:556.70Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Fórmula:C32H44O8Pureza:98.88% - 99.87%Forma y color:White SolidPeso molecular:556.69Ref: TM-T5S1467
1mg56,00€5mg109,00€1mL*10mM (DMSO)133,00€10mg168,00€25mg284,00€50mg423,00€100mg610,00€Cucurbitacin E
CAS:Carboxylic acid with additional oxygen functionsFórmula:C32H44O8Pureza:≥ 95.0 % (HPLC)Forma y color:PowderPeso molecular:556.7Cucurbitacin E
CAS:Producto controladoCucurbitacin E is a triterpenoid compound, which is a natural product derived from plants in the Cucurbitaceae family. This bioactive compound exerts its effects primarily through the disruption of cytoskeletal integrity, inhibition of the JAK/STAT signaling pathway, and induction of apoptosis. These molecular activities make it a potent agent in research focusing on cellular proliferation and inflammation.
Fórmula:C32H44O8Pureza:Min. 95%Peso molecular:556.69 g/molCucurbitacin E
CAS:Producto controladoApplications Cucurbitacin E is a biochemical compound from the family of Cucurbitacins. Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Cucurbitacin E is known to possess broad spectrum of potential anti-inflammatory, antitumor andantioxidant effects. In the wild, watermelons, cucumbers, and muskmelons produce bitter Cucurbitacins to defend against preditors. Humans have bred these fruits to eliminate these compounds thereby yielding fruits that are more appealing to our palate.
References Abbas, S., et al.: Toxicol. Lett., 216, 189 (2013); Zhang, T., et al.: Breast. Cancer. Res. Treatment., 135, 445 (2012); C&E News p. 10, Dec. 5, 2016Fórmula:C32H44O8Forma y color:NeatPeso molecular:556.69Cucurbitacin E
CAS:(R,E)-6-((8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-4,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetateFórmula:C32H44O8Pureza:98+%Peso molecular:556.69
