CAS 18771-50-1

Tetrahidrouridina

Descripción:

Tetrahidrouridina (THU) es un análogo de nucleósido que funciona principalmente como un inhibidor de la enzima citidina deaminasa, que está involucrada en el metabolismo de los nucleósidos. Su estructura química presenta un anillo de pirimidina con un moiety de tetrahidrofurano, lo que contribuye a sus propiedades únicas. Se conoce que THU tiene la capacidad de mejorar la biodisponibilidad de ciertos análogos de nucleósidos al prevenir su degradación, aumentando así su eficacia terapéutica. A menudo se estudia en el contexto de terapias antivirales y anticancerígenas, particularmente en combinación con otros análogos de nucleósidos. THU se administra típicamente en una forma farmacéutica, y su solubilidad y estabilidad son factores importantes en su aplicación. Además, se ha investigado su posible papel en la modulación de respuestas inmunitarias y en diversas aplicaciones de investigación bioquímica. Los perfiles de seguridad y toxicidad son consideraciones esenciales en su uso, y la investigación en curso continúa explorando su rango completo de actividades biológicas y potencial terapéutico.

Fórmula: C₉H₁₆N₂O₆

InChI: InChI=1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1

Clave InChI: InChIKey=UCKYOOZPSJFJIZ-XVKVHKPRSA-N

SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(O)CC2

Sinónimos:

• 1-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)-4-hydroxytetrahydro-1(1H)-pyrimidinone
• 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-
• 3,4,5,6-Tetrahydrouridine
• 4-hydroxy-1-(beta-D-ribofuranosyl)tetrahydropyrimidin-2(1H)-one
• 4-hydroxy-1-pentofuranosyltetrahydropyrimidin-2(1H)-one
• 5,6-Dihydrouridine
• Brn 0752319
• Nsc 112907
• Nsc-112907-D
• U 23284
• Uridine, 3,4,5,6-tetrahydro-
• Tetrahydrouridine
• 2(1H)-Pyrimidinone, tetrahydro-4-hydroxy-1-β-D-ribofuranosyl-

Tetrahydrouridine

CAS: 18771-50-1

Fórmula: C₉H₁₆N₂O₆

Pureza: 95%

Forma y color: Solid

Peso molecular: 248.2331

Ref: IN-DA0038WM

Tetrahydrouridine

CAS: 18771-50-1

Fórmula: C₉H₁₆N₂O₆

Peso molecular: 248.24

Ref: 4Z-C-357

3,4,5,6-Tetrahydrouridine (>80%)

CAS: 18771-50-1

Stability Light Sensitive
Applications 3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.
References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Funamizu, N., PLoS One, 37424 (2012);

Fórmula: C₉H₁₆N₂O₆

Pureza: >80%

Forma y color: Neat

Peso molecular: 248.23

Ref: TR-T310250

Tetrahydrouridine

CAS: 18771-50-1

Tetrahydrouridine is a pyrimidine nucleoside that has been shown to have inhibitory properties in clinical pathology. Tetrahydrouridine is a natural product derived from the amino acid histidine and is found in the cells of many living organisms. It is believed that tetrahydrouridine may be useful as an adjuvant to radiation therapy, and it has been shown to reduce the toxicity of chemotherapy drugs, such as decitabine and Ara-C. Tetrahydrouridine inhibits enzymes involved in DNA methylation, which can lead to cancer cell death.br>
Tetrahydrouridine also has inhibitory effects on enzymes that produce cytidine from uracil, which can help prevent the formation of cancerous cells.br>
Tetrahydrouridine inhibits deaminase activity, which produces uracil from cytosine. This inhibition prevents the production of uracil-cytosine

Fórmula: C₉H₁₆N₂O₆

Pureza: Min. 95%

Forma y color: White Off-White Powder

Peso molecular: 248.23 g/mol

Ref: 3D-NT171853

Tetrahydrouridine

CAS: 18771-50-1

Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.

Fórmula: C₉H₁₆N₂O₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 248.23

Ref: TM-T17059

Tetrahydrouridine

CAS: 18771-50-1

Fórmula: C₉H₁₆N₂O₆

Peso molecular: 248.24

Ref: ST-EA-CP-C52015