CAS 188968-51-6

Ácido 2-[(2S,5R,8S,11S)-5-bencil-11-[3-(diaminometilidenamino)propil]-7-metil-3,6,9,12,15-pentaoxo-8-propan-2-il-1,4,7,10,13-pentazaciclopentadec-2-il]acético

Descripción:

La sustancia química conocida como Ácido 2-[(2S,5R,8S,11S)-5-bencil-11-[3-(diaminometilidenamino)propil]-7-metil-3,6,9,12,15-pentaoxo-8-propan-2-il-1,4,7,10,13-pentazaciclopentadec-2-il]acético, con el número CAS 188968-51-6, es un compuesto orgánico complejo caracterizado por su estructura multicíclica y la presencia de múltiples grupos funcionales. Este compuesto presenta un esqueleto de pentazaciclopentadecano, que contribuye a su conformación tridimensional única y a su posible actividad biológica. La presencia de un grupo bencilo y de un moiety diaminometilidenoamino sugiere que puede exhibir interacciones interesantes con objetivos biológicos, posiblemente influyendo en sus propiedades farmacológicas. Además, el grupo funcional ácido acético indica potencial para solubilidad en disolventes polares y puede desempeñar un papel en la reactividad del compuesto. En general, la intrincada estructura y diversidad funcional de esta sustancia la convierten en un candidato para una investigación más profunda en química medicinal y campos relacionados.

Fórmula: C₂₇H₄₀N₈O₇

InChI: InChI=1/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,22-/m0/s1

Sinónimos:

• Cilengitide
• cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
• cyclo[L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl-N~5~-(diaminomethylidene)-L-ornithylglycyl]

Cilengitide

CAS: 188968-51-6

The cyclic RGD peptide cilengitide is a potential cancer drug. Cilengitide is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.

Fórmula: C₂₇H₄₀N₈O₇

Pureza: 97.6%

Forma y color: White

Peso molecular: 588.66

Ref: 01-4060586

Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-N-methyl-L-valyl)

CAS: 188968-51-6

Fórmula: C₂₇H₄₀N₈O₇

Pureza: 90%

Forma y color: Solid

Peso molecular: 588.6559

Ref: IN-DA002HLG

Cilengitide

CAS: 188968-51-6

Cilengitide

Pureza: ≥98%

Peso molecular: 588.66g/mol

Ref: 54-BUP07988

Cilengitide

CAS: 188968-51-6

Fórmula: C₂₇H₄₀N₈O₇

Pureza: 95%~99%

Forma y color: White to Off-white Powder

Peso molecular: 588.66

Ref: BP-BPPG018

Cilengitide

CAS: 188968-51-6

Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.

Fórmula: C₂₇H₄₀N₈O₇

Pureza: 98% - 99.8%

Forma y color: Solid

Peso molecular: 588.66

Ref: TM-T2494

Cilengitide

CAS: 188968-51-6

Cilengitide is a new chemotherapeutic agent that was shown to be effective against renal cell cancer in vitro. Cilengitide inhibits the polymerase chain reaction, arresting the growth of cells. It has minimal toxicity and natural compounds, which make it a promising drug for the treatment of human cancers. Cilengitide binds to integrin receptors on malignant brain cells and inhibits their ability to migrate, inducing apoptosis. This drug also inhibits the production of chemoattractant protein and can be used as an adjuvant therapy for radiation and antibiotic-resistant strains of bacteria.

Fórmula: C₂₇H₄₀N₈O₇

Pureza: Min. 95%

Peso molecular: 588.67 g/mol

Ref: 3D-RGD-3036-PI

Cilengitide

CAS: 188968-51-6

Pureza: 98%

Peso molecular: 588.302

Ref: 10-F813353

Cilengitide

CAS: 188968-51-6

Cilengitide is a peptide that inhibits the integrin receptor, which may be involved in tumorigenesis. It blocks the process of cellular transformation and inhibits tumor growth by blocking angiogenesis. Cilengitide has been shown to have minimal toxicity in vitro and in vivo, which is likely due to its low solubility in water. This peptide also has antitumor activity against solid tumours and can inhibit the growth of human breast cancer cells. Cilengitide was found to be effective in an experimental model using MDA-MB-231 breast cancer cells, demonstrating its potential for use as a therapeutic agent for cancer treatment.

Fórmula: C₂₇H₄₀N₈O₇

Pureza: Min. 95%

Peso molecular: 588.66 g/mol

Ref: 3D-NHA96851