CAS 18942-26-2

Ácido chebulínico

Descripción:

Ácido chebulínico es un compuesto polifenólico que se encuentra de forma natural principalmente en el fruto del árbol Terminalia chebula, conocido por sus propiedades medicinales en la medicina tradicional. Se caracteriza por su estructura compleja, que incluye múltiples grupos hidroxilo que contribuyen a su actividad antioxidante. El compuesto exhibe una variedad de actividades biológicas, incluyendo propiedades antiinflamatorias, antimicrobianas y anticancerígenas, lo que lo hace de interés en la investigación farmacológica. Ácido chebulínico es soluble en agua y en disolventes orgánicos, lo que mejora su biodisponibilidad. Su estructura química le permite interactuar con varios objetivos biológicos, potencialmente modulando vías celulares. Además, a menudo se estudia por su papel en la promoción de beneficios para la salud, como la mejora de las funciones metabólicas y la protección contra el estrés oxidativo. En general, Ácido chebulínico representa un área significativa de estudio en la química de productos naturales y sus aplicaciones en la salud y la medicina.

Fórmula: C₄₁H₃₂O₂₇

InChI: InChI=1S/C41H32O27/c42-15-1-10(2-16(43)26(15)51)35(56)62-9-22-31-33(66-36(57)11-3-17(44)27(52)18(45)4-11)34(41(63-22)68-37(58)12-5-19(46)28(53)20(47)6-12)67-38(59)13-7-21(48)29(54)32-25(13)24(30(55)40(61)65-32)14(8-23(49)50)39(60)64-31/h1-7,14,22,24,30-31,33-34,41-48,51-55H,8-9H2,(H,49,50)/t14-,22+,24-,30+,31+,33-,34+,41-/m0/s1

Clave InChI: InChIKey=YGVHOSGNOYKRIH-AVXZFDTDSA-N

SMILES: C(C(O)=O)[C@H]1[C@]2(C=3C(C(=O)O[C@@]4([C@@H](OC(=O)C5=CC(O)=C(O)C(O)=C5)[C@](OC1=O)([C@@H](COC(=O)C6=CC(O)=C(O)C(O)=C6)O[C@H]4OC(=O)C7=CC(O)=C(O)C(O)=C7)[H])[H])=CC(O)=C(O)C3OC(=O)[C@@H]2O)[H]

Sinónimos:

• (3,15,16-Trihydroxy-2,5,13-Trioxo-10,17-Bis[(3,4,5-Trihydroxybenzoyl)Oxy]-8-{[(3,4,5-Trihydroxybenzoyl)Oxy]Methyl}-2,3,3A,4,5,7,8,10,11,13-Decahydro-7,11-Methano[1,4,7]Trioxacyclotridecino[11,10,9-De]Chromen-4-Yl)Acetic Acid
• 7,11-Methanopyrano[4,3,2-kl][2,5,8]benzotrioxacyclotridecin, β-<span class="text-smallcaps">D</span>-glucopyranose deriv.
• Eutannin
• NSC 69862
• Nsc69862
• [(3S,3aS,4R,7R,8R,10S,11R,17S)-3,15,16-trihydroxy-2,5,13-trioxo-10,17-bis[(3,4,5-trihydroxybenzoyl)oxy]-8-{[(3,4,5-trihydroxybenzoyl)oxy]methyl}-2,3,3a,4,5,7,8,10,11,13-decahydro-7,11-methano[1,4,7]trioxacyclotridecino[11,10,9-de]chromen-4-yl]acetic acid
• [(3S,3aS,4S,7R,8R,10S,11R,17S)-3,15,16-trihydroxy-2,5,13-trioxo-10,17-bis[(3,4,5-trihydroxybenzoyl)oxy]-8-{[(3,4,5-trihydroxybenzoyl)oxy]methyl}-2,3,3a,4,5,7,8,10,11,13-decahydro-7,11-methano[1,4,7]trioxacyclotridecino[11,10,9-de]chromen-4-yl]acetic acid
• [(3S,4S)-3,15,16-trihydroxy-2,5,13-trioxo-10,17-bis[(3,4,5-trihydroxybenzoyl)oxy]-8-{[(3,4,5-trihydroxybenzoyl)oxy]methyl}-2,3,3a,4,5,7,8,10,11,13-decahydro-7,11-methano[1,4,7]trioxacyclotridecino[11,10,9-de]chromen-4-yl]acetic acid
• β-<span class="text-smallcaps">D</span>-Glucopyranose, 1,3,6-tris(3,4,5-trihydroxybenzoate), cyclic 2→2:4→1-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid
• Chebulinic acid
• β-D-Glucopyranose, 1,3,6-tris(3,4,5-trihydroxybenzoate), cyclic 2→2:4→1-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid

Chebulinic acid

CAS: 18942-26-2

Fórmula: C₄₁H₃₂O₂₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 956.6766

Ref: IN-DA00ABR9

Chebulinic acid

CAS: 18942-26-2

Chebulinic acid

Pureza: ≥98%

Peso molecular: 956.68g/mol

Ref: 54-BUP12585

Chebulinic acid

CAS: 18942-26-2

Fórmula: C₄₁H₃₂O₂₇

Pureza: 95%~99%

Peso molecular: 956.68

Ref: BP-BP0339

Chebulinic acid

CAS: 18942-26-2

Fórmula: C₄₁H₃₂O₂₇

Pureza: ≥ 95.0%

Forma y color: White to off-white solid

Peso molecular: 956.68

Ref: 7W-GK3169

Chebulinic acid

CAS: 18942-26-2

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.

Fórmula: C₄₁H₃₂O₂₇

Pureza: 98.91% - 99.71%

Forma y color: Solid

Peso molecular: 956.68

Ref: TM-TQ0184

Chebulinic acid

CAS: 18942-26-2

Natural glycoside

Fórmula: C₄₁H₃₂O₂₇

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 956.69

Ref: 5G-80572

Chebulinic Acid

CAS: 18942-26-2

Applications Chebulinic Acid has been shown to prevent epithelial mesenchymal transition in retinal pigment epithelial cells through inhibition of SMAD-3 phosphorylation. This prevents retinal detachment in the process of proliferative vitreoretinopathy.
References Sivasankar, S. et al.: PLoS One., 10, e0120512 (2015);

Fórmula: C₄₁H₃₂O₂₇

Forma y color: Off-White

Peso molecular: 956.68

Ref: TR-C291895

Chebulinic acid

CAS: 18942-26-2

Chebulinic acid is a polyphenolic compound, which is derived primarily from the fruits of Terminalia chebula, a species belonging to the Combretaceae family. Terminalia chebula is a deciduous tree native to southern Asia, and its fruits have been extensively used in traditional medicinal systems such as Ayurveda due to their pharmacological potential.

Fórmula: C₄₁H₃₂O₂₇

Pureza: Min 98%

Ref: 3D-FC138782