CAS 191114-48-4: Telitromicina

Descripción: Telitromicina es un antibiótico sintético que pertenece a la clase de los cetolidos, utilizado principalmente para tratar infecciones del tracto respiratorio causadas por diversas bacterias. Presenta un amplio espectro de actividad contra organismos Gram-positivos y algunos Gram-negativos, lo que lo hace efectivo contra patógenos como Streptococcus pneumoniae y Haemophilus influenzae. Telitromicina actúa inhibiendo la síntesis de proteínas bacterianas al unirse a la subunidad ribosomal 50S, impidiendo así el crecimiento y la reproducción de las bacterias. Su estructura química presenta un grupo cetona y un esqueleto macrólido, que contribuyen a sus propiedades farmacológicas únicas. Telitromicina se administra por vía oral y es conocido por su vida media relativamente larga, lo que permite una dosificación una vez al día. Sin embargo, se asocia con efectos secundarios potenciales, incluidos trastornos gastrointestinales y, en casos raros, toxicidad hepática. Debido a preocupaciones sobre la resistencia y la seguridad, su uso se ha vuelto más restringido en los últimos años. En general, Telitromicina representa una opción importante en el arsenal de antibióticos, particularmente para tratar infecciones bacterianas específicas.

Fórmula: C₄₃H₆₅N₅O₁₀

InChI: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1

Clave InChI: InChIKey=LJVAJPDWBABPEJ-PNUFFHFMSA-N

SMILES: O=C1OC2(C)C(OC(=O)C(C(=O)C(C)C(OC3OC(C)CC(N(C)C)C3O)C(OC)(C)CC(C(=O)C(C)C2N1CCCCN4C=NC(=C4)C=5C=NC=CC5)C)C)CC

Sinónimos:

• (1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• (3aS,4S,7R,9R,10R,11R,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside - 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione (1:1)
• (3aS,4S,7R,9R,10R,11S,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-
• Erythromycin, 3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</span>-ribo-hexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]-
• Hmr 3647
• Ketek
• Levviax
• Ru 66647
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-
• Erythromycin, 3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]-

Telithromycin, 95%

CAS: 191114-48-4

Telithromycin is used to treat respiratory infections. Telithromycin prevents bacteria from growing, by interfering with …

• Fórmula: C₄₃H₆₅N₅O₁₀
• Pureza: 95%
• Forma y color: Crystalline solid
• Peso molecular: 812.02

2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-

CAS: 191114-48-4

• Fórmula: C₄₃H₆₅N₅O₁₀
• Pureza: 99%
• Forma y color: Solid
• Peso molecular: 812.0037

Telithromycin

CAS: 191114-48-4

• Fórmula: C₄₃H₆₅N₅O₁₀
• Pureza: ≥ 98.0%
• Forma y color: White to off-white powder
• Peso molecular: 812.00

Telithromycin

CAS: 191114-48-4

Telithromycin (HMR3647) is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate …

• Fórmula: C₄₃H₆₅N₅O₁₀
• Pureza: 98%
• Forma y color: Solid
• Peso molecular: 812.02

Telithromycin

CAS: 191114-48-4

• Fórmula: C₄₃H₆₅N₅O₁₀
• Peso molecular: 812.02

Telithromycin 90%

CAS: 191114-48-4

Applications Telithromycin is a ketolide antibiotic, used to treat respiratory infections References Lee, J., et …

• Fórmula: C₄₃H₆₅N₅O₁₀
• Pureza: 90%
• Forma y color: Light Orange Colour
• Peso molecular: 812.00

Telithromycin

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

• Fórmula: C₄₃H₆₅N₅O₁₀
• Pureza: Min. 95%
• Forma y color: White Powder
• Peso molecular: 812 g/mol

Telithromycin - 98%

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

• Fórmula: C₄₃H₆₅N₅O₁₀
• Pureza: Min. 95%
• Forma y color: Powder
• Peso molecular: 812 g/mol