CAS 191114-48-4

Telitromicina

Descripción:

Telitromicina es un antibiótico sintético que pertenece a la clase de los cetolidos, utilizado principalmente para tratar infecciones del tracto respiratorio causadas por diversas bacterias. Presenta un amplio espectro de actividad contra organismos Gram-positivos y algunos Gram-negativos, lo que lo hace efectivo contra patógenos como Streptococcus pneumoniae y Haemophilus influenzae. Telitromicina actúa inhibiendo la síntesis de proteínas bacterianas al unirse a la subunidad ribosomal 50S, impidiendo así el crecimiento y la reproducción de las bacterias. Su estructura química presenta un grupo cetona y un esqueleto macrólido, que contribuyen a sus propiedades farmacológicas únicas. Telitromicina se administra por vía oral y es conocido por su vida media relativamente larga, lo que permite una dosificación una vez al día. Sin embargo, se asocia con efectos secundarios potenciales, incluidos trastornos gastrointestinales y, en casos raros, toxicidad hepática. Debido a preocupaciones sobre la resistencia y la seguridad, su uso se ha vuelto más restringido en los últimos años. En general, Telitromicina representa una opción importante en el arsenal de antibióticos, particularmente para tratar infecciones bacterianas específicas.

Fórmula: C₄₃H₆₅N₅O₁₀

InChI: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1

Clave InChI: InChIKey=LJVAJPDWBABPEJ-PNUFFHFMSA-N

SMILES: C[C@@]12[C@](N(CCCCN3C=C(N=C3)C=4C=CC=NC4)C(=O)O1)([C@@H](C)C(=O)[C@H](C)C[C@](OC)(C)[C@H](O[C@H]5[C@H](O)[C@@H](N(C)C)C[C@@H](C)O5)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@@H]2CC)[H]

Sinónimos:

• (1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• (3aS,4S,7R,9R,10R,11R,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside - 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione (1:1)
• (3aS,4S,7R,9R,10R,11S,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-<span class="text-smallcaps">D</span>-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-
• Erythromycin, 3-de[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-<span class="text-smallcaps">L</span>-ribo-hexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]-
• Hmr 3647
• Ketek
• Levviax
• Ru 66647
• (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone
• 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-

2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-

CAS: 191114-48-4

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: 99%

Forma y color: Solid

Peso molecular: 812.0037

Ref: IN-DA002F1S

Telithromycin

CAS: 191114-48-4

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 812.00

Ref: 7W-GA2425

Telithromycin

CAS: 191114-48-4

Telithromycin is a macrolide antibiotic and erythromycin derivative,70S bacterial ribosome, antimicrobial, respiratory infections,inhibits protein synthesis.

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: 98%

Forma y color: Solid

Peso molecular: 812

Ref: TM-T4543

Telithromycin

CAS: 191114-48-4

Fórmula: C₄₃H₆₅N₅O₁₀

Peso molecular: 812.02

Ref: 4Z-T-443001

Telithromycin 90%

Producto controlado

CAS: 191114-48-4

Applications Telithromycin is a ketolide antibiotic, used to treat respiratory infections
References Lee, J., et al.: Pulmonary Pharmacology & Therapeutics, 21, 860 (2008), Wajima, T., et al.: J. Med. Microbiol., 57, 1383 (2008), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009),

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: 90%

Forma y color: Light Orange Colour

Peso molecular: 812.00

Ref: TR-T016500

Telithromycin - 95%

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 812 g/mol

Ref: 3D-AT164862

Telithromycin

CAS: 191114-48-4

Ketolide; binds bacterial ribosomes and inhibits translation

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 812 g/mol

Ref: 3D-AT28021

Telithromycin, 95%

CAS: 191114-48-4

Telithromycin is used to treat respiratory infections. Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Fórmula: C₄₃H₆₅N₅O₁₀

Pureza: 95%

Forma y color: Crystalline solid

Peso molecular: 812.02

Ref: 02-J66820