CAS 19171-19-8
:Pomalidomida
Descripción:
Pomalidomida es un fármaco inmunomodulador utilizado principalmente en el tratamiento del mieloma múltiple y ciertos otros malignidades hematológicas. Pertenece a una clase de compuestos conocidos como análogos de la talidomida, que ejercen sus efectos a través de varios mecanismos, incluyendo la modulación del sistema inmunológico y la inhibición del crecimiento tumoral. La fórmula química de Pomalidomida es C13H11N3O4S, y presenta una estructura única que incluye un anillo de ftalimida, un grupo sulfonamida y una cadena lateral aromática. Pomalidomida es conocido por su capacidad para mejorar la actividad de las células T y las células asesinas naturales, así como por sus propiedades antiangiogénicas, que ayudan a inhibir la formación de nuevos vasos sanguíneos que los tumores requieren para crecer. El fármaco se administra típicamente por vía oral y tiene una vida media relativamente larga, lo que permite horarios de dosificación convenientes. Sin embargo, está asociado con efectos secundarios potenciales, incluyendo toxicidades hematológicas, y requiere un monitoreo cuidadoso durante el tratamiento. En general, Pomalidomida representa un avance significativo en las terapias dirigidas contra el cáncer.
Fórmula:C13H11N3O4
InChI:InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
Clave InChI:InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N
SMILES:O=C1N(C(=O)C=2C1=CC=CC2N)C3C(=O)NC(=O)CC3
Sinónimos:- 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
- 2-(2,6-Dioxopiperidin-3-yl)-4-amino-isoindole-1,3-dione
- 3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
- 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
- 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
- 4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- 4-Amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
- 4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
- Actimid
- Cc 4047
- Imnovid
- Phthalimide, 3-amino-N-(2,6-dioxo-3-piperidyl)-
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Encontrado 15 productos.
Pomalidomide
CAS:Fórmula:C13H11N3O4Pureza:>98.0%(HPLC)Forma y color:White to Yellow to Green powder to crystalinePeso molecular:273.254-amino-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS:Fórmula:C13H11N3O4Pureza:98%Forma y color:SolidPeso molecular:273.2441Pomalidomide
CAS:Pomalidomide (CC-4047) is an anti-angiogenic and immunomodulatory agent. Pomalidomide is a ligand for CRBN. Cost-effective and quality-assured.Fórmula:C13H11N3O4Pureza:98.8% - >99.99%Forma y color:SolidPeso molecular:273.24Pomalidomide
CAS:Fórmula:C13H11N3O4Pureza:≥ 98.5%Forma y color:Yellow to green powderPeso molecular:273.24Pomalidomide
CAS:Applications Pomalidomide is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)Fórmula:C13H11N3O4Forma y color:YellowPeso molecular:273.24Pomalidomide - Bio-X ™
CAS:Producto controladoPomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM. In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies. Pomalidomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C13H11N3O4Pureza:Min. 99 Area-%Forma y color:PowderPeso molecular:273.24 g/molPomalidomide
CAS:Producto controladoPomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM.In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.Fórmula:C13H11N3O4Pureza:Min. 98 Area-%Forma y color:Yellow PowderPeso molecular:273.24 g/mol4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:Fórmula:C13H11N3O4Pureza:98%Forma y color:SolidPeso molecular:273.248Pomalidomide-d5
CAS:Producto controladoApplications Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
References Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)Fórmula:C13D5H6N3O4Forma y color:NeatPeso molecular:278.27Pomalidomide-d2 (Major)
CAS:Producto controladoFórmula:C13D2H9N3O4Forma y color:NeatPeso molecular:275.26
