CAS 19186-35-7

(5R,5aR,8aR)-5-(3,4,5-trimetoxifenil)-5,8,8a,9-tetrahidrofurano[3',4':6,7]nafto[2,3-d][1,3]dioxol-6(5aH)-ona

Descripción:

La sustancia química con el nombre "(5R,5aR,8aR)-5-(3,4,5-trimetoxifenil)-5,8,8a,9-tetrahidrofurano[3',4':6,7]nafto[2,3-d][1,3]dioxol-6(5aH)-ona" y el número CAS "19186-35-7" es un compuesto orgánico complejo caracterizado por su intrincada estructura policíclica, que incluye un núcleo de naftaleno fusionado con un dioxolano y un moiety de tetrahidrofurano. Este compuesto presenta múltiples grupos metoxi, que son conocidos por mejorar la solubilidad e influir en la actividad biológica. La estereoquímica indicada por las configuraciones R sugiere arreglos espaciales específicos que pueden afectar significativamente la reactividad del compuesto y sus interacciones con los objetivos biológicos. Tales compuestos a menudo exhiben propiedades farmacológicas interesantes, lo que los convierte en sujetos de interés en la química medicinal. Además, la presencia de múltiples grupos funcionales puede llevar a una reactividad química diversa, permitiendo modificaciones potenciales que podrían mejorar la eficacia terapéutica o reducir la toxicidad. En general, este compuesto ejemplifica la complejidad y diversidad que se encuentra en la química orgánica, particularmente en el ámbito de la síntesis de productos naturales y el desarrollo de fármacos.

Fórmula: C₂₂H₂₂O₇

InChI: InChI=1/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1

Clave InChI: InChIKey=ZGLXUQQMLLIKAN-SVIJTADQSA-N

SMILES: O=C1[C@@]2([C@@H](C=3C(C[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(OC)C(OC)=C5)[H]

Sinónimos:

• (-)-Anthricin
• (5R,5aR,8aR)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• 4-Deoxypodophyllotoxin
• As 2-3
• Deoxypodophyllotoxin
• Desoxypodophyllotoxin
• Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, [5R-(5α,5aβ,8aα)]-
• Podophyllotoxin, deoxy-
• Silicicolin
• Anthricin/Deoxypodophyllotoxin
• anthric
• Podophyllotoxin 9-Desoxy Impurity
• Deoxypodophyllotoxin, deoxypodophyllotoxin

(-)-Deoxypodophyllotoxin

CAS: 19186-35-7

Fórmula: C₂₂H₂₂O₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 398.4059

Ref: IN-DA002FHT

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin

Pureza: ≥98%

Peso molecular: 398.41g/mol

Ref: 54-BUP16322

Deoxypodophyllotoxin

CAS: 19186-35-7

Fórmula: C₂₂H₂₂O₇

Peso molecular: 398.41

Ref: 7W-GY9442

Podophyllotoxin Impurity 5

CAS: 19186-35-7

Fórmula: C₂₂H₂₂O₇

Forma y color: White To Off-White Solid

Peso molecular: 398.41

Ref: 4Z-P-122005

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. Deoxypodophyllotoxin induces G2 /M cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of ATM, upregulation of p53 and Bax, activation of caspase-3 and -7, and accumulation of PTEN resulting in the inhibition of the Akt pathway. Deoxypodophyllotoxin maybe applicable to treat hyperpigmentation, it decreases UV-induced skin pigmentation of brown guinea pigs.

Fórmula: C₂₂H₂₂O₇

Pureza: 95%~99%

Peso molecular: 398.41

Ref: BP-SBP02032

Deoxypodophyllotoxin

CAS: 19186-35-7

Deoxypodophyllotoxin is cytotoxic, antineoplastic, anti-tumor, anti-angiogenic, antiviral, and anti-inflammatory.

Fórmula: C₂₂H₂₂O₇

Pureza: 99.65% - 99.84%

Forma y color: Solid

Peso molecular: 398.41

Ref: TM-TN1087

4-Deoxypodophyllotoxin

CAS: 19186-35-7

4-Deoxypodophyllotoxin is a natural lignan, which is a type of secondary metabolite. It is primarily sourced from the roots and rhizomes of several plants belonging to the Podophyllum species, such as Podophyllum hexandrum. This compound exhibits its mode of action by interfering with microtubule assembly, thus disrupting cell division and leading to apoptotic cell death. Its effectiveness at halting mitosis makes it a subject of interest in cancer research.

Fórmula: C₂₂H₂₂O₇

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 398.41 g/mol

Ref: 3D-FD157413

4-Deoxypodophyllotoxin

Producto controlado

CAS: 19186-35-7

Applications 4-Deoxypodophyllotoxin is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. It is well known for its antitumor, antiviral, and anti-inflammatory activities. 4-Deoxypodophyllotoxin was also shown to inhibit the passive cutaneous anaphylaxis reaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lin, C.X., et al.: Planta. Med., 70, 474 (2004); Peng, Xu., et al.: Neurotoxicol., 31, 680 (2010); Kim, Y., et al.: Planta, Med., 68, 271 (2002);

Fórmula: C₂₂H₂₂O₇

Forma y color: Off-White

Peso molecular: 398.41

Ref: TR-D249500