CAS 1926163-13-4

E-76

CAS: 1926163-13-4

E-76 is a peptide with anticoagulant activity that inhibits blood coagulation by specifically binding to the exogenous coagulation factor VIIa (FVIIa). It is utilized in the study of blood coagulation-related diseases.

Fórmula: C₉₇H₁₃₉N₂₇O₂₉S₂

Peso molecular: 2211.44

Ref: TM-TP2741

Ac-Ala-Leu-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH2 (Disulfide bond)

CAS: 1926163-13-4

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Fórmula: C₉₇H₁₃₉N₂₇O₂₉S₂

Pureza: Min. 95%

Peso molecular: 2,211.44 g/mol

Ref: 3D-FA109396

Ac-Ala-Leu-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH₂

CAS: 1926163-13-4

The potent anticoagulant E-76, Acetyl-ALCDDPRVDRWYCQFVEG-amide, is an inhibitor of coagulation factor VIIa. It has been suggested that E-76 works by binding to an exosite on the factor VIIa protease domain, and non-competitively inhibits activation of factor X and amidolytic activity. E-76 has a well defined structure in solution determined by NMR spectroscopy that is similar to the X-ray crystal structure when complexed with factor VIIa and represents a new framework for the development of inhibitors for serine proteases.

Fórmula: C₉₇H₁₃₉N₂₇O₂₉S₂

Pureza: 95.9%

Peso molecular: 2211.47

Ref: 01-4033397