CAS 193079-69-5

Tabimorelina

Descripción:

Tabimorelina, con el número CAS 193079-69-5, es un péptido sintético que funciona como un secretagogo de la hormona del crecimiento. Se utiliza principalmente en entornos de investigación para estimular la liberación de la hormona del crecimiento de la glándula pituitaria. Tabimorelina actúa sobre el receptor de grelina, imitando la acción de la grelina, una hormona que juega un papel crucial en la regulación del apetito y el equilibrio energético. Este compuesto se caracteriza por su capacidad para aumentar los niveles de hormona del crecimiento, lo que puede tener implicaciones en diversas áreas terapéuticas, incluyendo la deficiencia de hormona del crecimiento y los trastornos metabólicos. Tabimorelina se administra típicamente por inyección y se ha estudiado por sus posibles efectos en la composición corporal, la masa muscular y la salud metabólica en general. Su farmacocinética y perfil de seguridad son temas de investigación en curso, y aunque muestra promesas, se necesitan más estudios para comprender completamente su eficacia y posibles aplicaciones en la práctica clínica. Al igual que con cualquier péptido, la estabilidad, las condiciones de almacenamiento y el manejo adecuado son esenciales para mantener su integridad y efectividad.

Fórmula: C₃₂H₄₀N₄O₃

InChI: InChI=1S/C32H40N4O3/c1-32(2,33)19-11-16-29(37)35(4)28(22-24-17-18-25-14-9-10-15-26(25)20-24)31(39)36(5)27(30(38)34-3)21-23-12-7-6-8-13-23/h6-18,20,27-28H,19,21-22,33H2,1-5H3,(H,34,38)/b16-11+/t27-,28-/m1/s1

Clave InChI: InChIKey=WURGZWOTGMLDJP-ZCYANPAGSA-N

SMILES: [C@@H](CC1=CC2=C(C=C1)C=CC=C2)(C(N([C@H](CC3=CC=CC=C3)C(NC)=O)C)=O)N(C(/C=C/CC(C)(C)N)=O)C

Sinónimos:

• (R)-alpha-((E)-5-Amino-N,5-dimethyl-2-hexenamido)-N-methyl-N-((R)-alpha-(methylcarbamoyl)phenethyl)-2-naphthalenepropionamide
• <span class="text-smallcaps">D</smallcap>-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-<smallcap>D</span>-alanyl-N,N^α-dimethyl-
• <span class="text-smallcaps">D</smallcap>-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-<smallcap>D</span>-alanyl-N,N^α-dimethyl-
• N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-<span class="text-smallcaps">D</smallcap>-alanyl-N,N^α-dimethyl-<smallcap>D</span>-phenylalaninamide
• N-[(2E)-5-amino-5-methylhex-2-enoyl]-N-methyl-3-(naphthalen-2-yl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide
• Nn 703
• Nnc 26-0703
• Tabimorelin [INN]
• Unii-L51Cbe03Kf
• N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide
• Tabimorelin
• D-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-
• D-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-
• N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamidehemifumarate
• NNC26-0703
• N-[5-Amino-5-Methyl-2(E)-Hexenoyl]-N-Methyl-3-(2- Naphthyl)-D-Alanyl-N-Methyl-D-Phenylalanine Methylamide
• NNC-260703

Tabimorelin

CAS: 193079-69-5

Fórmula: C₃₂H₄₀N₄O₃

Peso molecular: 528.70

Ref: 4Z-T-172001

Tabimorelin

Producto controlado

CAS: 193079-69-5

Applications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.
References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),

Fórmula: C₃₂H₄₀N₄O₃

Forma y color: Neat

Peso molecular: 528.68

Ref: TR-T003500

Tabimorelin

CAS: 193079-69-5

Tabimorelin is a potent analog of the endogenous hormone ghrelin. It binds to the ghrelin receptor and stimulates appetite, thereby increasing food intake and weight gain. Tabimorelin also has been shown to be effective in treating bowel disease, diabetic neuropathy, and symptoms of inflammatory bowel disease. The pharmacological effects of tabimorelin are due to its ability to bind to receptors in the gastrointestinal tract. This drug also has an effect on coordination complex formation by human liver microsomes. Tabimorelin can be used as a diagnostic tool for some types of cancer because it is not metabolized by enzymes in healthy cells, but is metabolized by enzymes in cancer cells. The use of tabimorelin as an analytical method is based on its ability to form coordination complexes with heavy metals such as mercury or lead.

Fórmula: C₆₈H₈₄N₈O₁₀

Pureza: Min. 95%

Peso molecular: 1,173.4 g/mol

Ref: 3D-THA07969