CAS 19396-06-6

Polioxina B

Descripción:

Polioxina B es un compuesto antifúngico natural producido por la fermentación de ciertas especies de Streptomyces, particularmente Streptomyces griseus. Se clasifica como un antibiótico nucleósido y es conocido principalmente por su capacidad para inhibir la síntesis de quitina, un componente crítico de las paredes celulares de los hongos. Este mecanismo de acción hace que Polioxina B sea efectivo contra una variedad de patógenos fúngicos, particularmente en entornos agrícolas donde se utiliza como biopesticida. El compuesto exhibe un amplio espectro de actividad antifúngica, dirigiéndose a hongos como las especies de Fusarium y Rhizoctonia. Polioxina B se caracteriza por su toxicidad relativamente baja para los mamíferos, lo que lo convierte en una alternativa más segura a los fungicidas sintéticos. Además, es soluble en agua, lo que permite una fácil aplicación en diversas formulaciones. Su uso es particularmente valorado en la agricultura orgánica debido a su origen natural y su mínimo impacto ambiental. En general, Polioxina B representa una herramienta importante en el manejo de enfermedades fúngicas en cultivos mientras promueve prácticas agrícolas sostenibles.

Fórmula: C₁₇H₂₅N₅O₁₃

InChI: InChI=1S/C17H25N5O13/c18-6(8(25)5(24)3-34-16(19)32)13(29)20-7(15(30)31)11-9(26)10(27)14(35-11)22-1-4(2-23)12(28)21-17(22)33/h1,5-11,14,23-27H,2-3,18H2,(H2,19,32)(H,20,29)(H,30,31)(H,21,28,33)/t5-,6-,7-,8+,9-,10+,11+,14+/m0/s1

Clave InChI: InChIKey=YFZNSPMAOIVQRP-YVKGXWRCSA-N

SMILES: O[C@H]1[C@@H](O[C@]([C@H](NC([C@H]([C@@H]([C@H](COC(N)=O)O)O)N)=O)C(O)=O)([C@H]1O)[H])N2C=C(CO)C(=O)NC2=O

Sinónimos:

• (2S)-{[(2S,3S,4S)-2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}{(2R,3S,4R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}ethanoic acid (non-preferred name)
• (2S)-{[(2S,3S,4S)-2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}{(2R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}ethanoic acid (non-preferred name)
• 5-(2-Amino-5-O-carbamoyl-2-deoxy-L-xylonamido)-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-beta-D-allofuranuronic acid
• 5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-<span class="text-smallcaps">L</smallcap>-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-β-<smallcap>D</span>-allofuranuronic acid
• Allofuranuronic acid, 5-(2-amino-2-deoxy-<span class="text-smallcaps">L</smallcap>-xylonamido)-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-, monocarbamate (ester), β-<smallcap>D</span>-
• Allofuranuronic acid, 5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-(3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl)-, monocarbamate (ester), beta-D-
• Duoyangqing
• Milpan
• Polar
• Polar (antibiotic)
• Polyoxin AL
• Polyoxin B
• Polyoxin B 34% Tk
• {[2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}{3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}acetic acid (non-preferred name)
• β-<span class="text-smallcaps">D</smallcap>-Allofuranuronic acid, 5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-<smallcap>L</span>-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-
• Allofuranuronic acid, 5-(2-amino-2-deoxy-L-xylonamido)-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-, monocarbamate (ester), β-D-
• 5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-β-D-allofuranuronic acid
• β-D-Allofuranuronic acid, 5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-
• 5-(2-amino-5-o-carbamoyl-2-deoxy-l-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1-(2h)-pyrimidinyl)-beta-d-allofuranuronicacid
• 5-[[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]-β-D-allofuranuronic acid
• 5-[[2-amino-5-o-(aminocarbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronicacid
• ro-5-(hydroxymethyl)-2,4-dioxo-1(2h)-pyrimidinyl)-,monocarbamate(ester),bet
• polyoxin AL(JMAF)
• polyoxinal
• 5-[(2-Amino-5-O-carbamoyl-2-deoxy-L-xylonoyl)amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxopyrimidin-1(2H)-yl]-β-D-allofuranuronic acid
• 5-[2-Amino-5-O-(aminocarbonyl)-2-deoxy-L-xylos-1-ylamino]-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxopyrimidin-1(2H)-yl)-1,5-dideoxy-β-D-allofuranuronic acid
• 5-[[2-amino-5-o-(aminocarbonyl)-2-deoxy-l-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymeth.beta.-d-Allofuranuronic acid
• allofuranuronicacid,5-(2-amino-2-deoxy-l-xylonamido)-1,5-dideoxy-1-(3,4-dihyd
• 5-{[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl] amino}-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimnidinyl]-β-D-allofur-a-nuronic acid
• POLYXIN

b-D-Allofuranuronic acid,5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-

CAS: 19396-06-6

Fórmula: C₁₇H₂₅N₅O₁₃

Pureza: 70%

Forma y color: Solid

Peso molecular: 507.4061

Ref: IN-DA00I31H

Polyoxin b

CAS: 19396-06-6

Polyoxin b

Fórmula: C₁₇H₂₅N₅O₁₃

Pureza: ≥95%

Forma y color: solid

Peso molecular: 507.41g/mol

Ref: 54-OR927861

Polyoxin B

CAS: 19396-06-6

Polyoxin B

Pureza: ≥70%

Peso molecular: 507.41g/mol

Ref: 54-BUP03267

Polyoxin B

CAS: 19396-06-6

Fórmula: C₁₇H₂₅N₅O₁₃

Peso molecular: 507.41

Ref: 4Z-P-288002

Polyoxin B

CAS: 19396-06-6

Polyoxin B is an antifungal peptidyl nucleoside antibiotic that inhibits fungal cell wall biosynthesis.

Fórmula: C₁₇H₂₅N₅O₁₃

Pureza: 79.94%

Forma y color: Solid

Peso molecular: 507.41

Ref: TM-T28436

Polyoxin B

CAS: 19396-06-6

Polyoxin B is a natural product that is produced by the fungus Polyporus umbellatus. It is a synthetase inhibitor that specifically inhibits the enzyme malic acid synthetase in bacteria and fungi. Polyoxin B has been shown to have antifungal activity in vitro and to inhibit the growth of Cryptococcus neoformans, which may be due to its ability to inhibit terminal residues, such as acetate extract, bacterial strain, and synthase enzyme.

Fórmula: C₁₇H₂₅N₅O₁₃

Pureza: Min. 70%

Forma y color: Yellow Powder

Peso molecular: 507.41 g/mol

Ref: 3D-NP140526