CAS 19685-09-7

Hidroxi-camptotecina

Descripción:

Hidroxi-camptotecina es un potente alcaloide derivado de la planta Camptotheca acuminata, conocido por sus propiedades anticancerígenas. Pertenece a la clase de compuestos llamados camptotecinas, que se caracterizan por su capacidad para inhibir la enzima topoisomerasa I, lo que lleva a daños en el ADN y apoptosis en las células cancerosas. Hidroxi-camptotecina exhibe una estructura única que presenta un sistema de anillo pentacíclico, que es crucial para su actividad biológica. Este compuesto es típicamente soluble en disolventes orgánicos y tiene una solubilidad limitada en agua, lo que puede presentar desafíos para su formulación en aplicaciones farmacéuticas. Su potencial terapéutico ha sido explorado en varios tipos de cáncer, incluidos el cáncer colorrectal y el cáncer de ovario. Sin embargo, su uso clínico a menudo se ve limitado por problemas como la toxicidad y la estabilidad. La investigación continúa enfocándose en mejorar su perfil farmacológico y desarrollar derivados que aumenten su eficacia y reduzcan los efectos secundarios. En general, Hidroxi-camptotecina representa un compuesto significativo en el campo de la terapia contra el cáncer, con estudios en curso destinados a optimizar su uso en entornos clínicos.

Fórmula: C₂₀H₁₆N₂O₅

InChI: InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

Clave InChI: InChIKey=HAWSQZCWOQZXHI-FQEVSTJZSA-N

SMILES: O=C1N2C(C=3C(C2)=CC=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@@]5(CC)O

Sinónimos:

• (+/-)-4-Ethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
• (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 10-Hcpt
• 10-Hydroxy Camptothecin
• 10-Hydroxycamptothecin
• 10-Hydroxycamptothecine
• 10Hydroxy Camptothecin
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (S)-
• 7-Ethy Hydroxycamptothecin
• Camptothecine, 10-hydroxy-
• ChEMBL 273862
• Hydroxy camptothecine
• Hydroxycamptothecin

10-Hydroxycamptothecin

CAS: 19685-09-7

Fórmula: C₂₀H₁₆N₂O₅

Pureza: >98.0%(HPLC)

Forma y color: White to Yellow to Orange powder to crystal

Peso molecular: 364.36

Ref: 3B-H1463

Irinotecan Related Compound A ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

CAS: 19685-09-7

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

Fórmula: C₂₀H₁₆N₂O₅

Forma y color: Light Yellow Powder

Peso molecular: 364.10592

Ref: 45-1347610

(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

CAS: 19685-09-7

Fórmula: C₂₀H₁₆N₂O₅

Pureza: %

Forma y color: Solid

Peso molecular: 364.3514

Ref: IN-DA0032GC

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

(S)-10-Hydroxycamptothecin

Pureza: 98%

Peso molecular: 364.35g/mol

Ref: 54-OR1008613

Irinotecan EP Impurity B (Irinotecan USP Related Compound A, 10-Hydroxy Camptothecin)

CAS: 19685-09-7

Fórmula: C₂₀H₁₆N₂O₅

Peso molecular: 364.36

Ref: 4Z-I-1838

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

(S)-10-Hydroxycamptothecin

Pureza: ≥98%

Peso molecular: 364.35g/mol

Ref: 54-BUP13827

(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ((S)-10-Hydroxycamptothecin)

CAS: 19685-09-7

Forma y color: Neat

Ref: 86-MM1157.02

10-Hydroxycamptothecin

CAS: 19685-09-7

Fórmula: C₂₀H₁₆N₂O₅

Pureza: 95%~99%

Peso molecular: 364.35

Ref: BP-BP0014

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.

Fórmula: C₂₀H₁₆N₂O₅

Pureza: 99.09% - 99.81%

Forma y color: Solid

Peso molecular: 364.35

Ref: TM-T2764

Irinotecan EP Impurity B

CAS: 19685-09-7

Fórmula: C₂₀H₁₆N₂O₅

Peso molecular: 364.36

Ref: ST-EA-CP-I9017

9-Hydroxycamptothecin

CAS: 19685-09-7

Fórmula: C₂₀H₁₆N₂O₅

Peso molecular: 364.36

Ref: ST-EA-CP-C88015

10-Hydroxy Camptothecin

Producto controlado

CAS: 19685-09-7

Impurity Irinotecan USP Related Compound A
Applications A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Irinotecan USP Related Compound A
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wani, M.C., et al.: J. Med. Chem., 29, 2358 (1986), Miller, K.D., et al.: Invest. New Drugs, 22, 69 (2004), Punt, C.J.A., et al.: Eur. J. Cancer, 40, 1332 (2004), Wang, J.-Q., et al.: Bioorg. Med. Chem., 13, 549 (2005),

Fórmula: C₂₀H₁₆N₂O₅

Forma y color: Yellow

Peso molecular: 364.35

Ref: TR-H875000

10-Hydroxycamptothecin

CAS: 19685-09-7

10-Hydroxycamptothecin is an alkaloid, which is derived from the bark and stem of the Camptotheca acuminata tree, commonly known as the "Happy Tree." This compound is a potent topoisomerase I inhibitor. Its mode of action involves binding to the topoisomerase I-DNA complex, stabilizing it and thus preventing the re-ligation of DNA single-strand breaks. This interruption in the DNA replication process leads to DNA damage, ultimately triggering apoptosis in rapidly dividing cells.

Fórmula: C₂₀H₁₆N₂O₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 364.35 g/mol

Ref: 3D-FH16009

(S)-10-Hydroxycamptothecin

CAS: 19685-09-7

Pureza: 98%

Peso molecular: 364.36

Ref: 10-F787618