CAS 19804-27-4

4-Metildifenhidramina

Descripción:

4-Metildifenhidramina es un antihistamínico que pertenece a la clase de la difenhidramina, utilizado principalmente por sus propiedades sedantes y anti-alérgicas. Se caracteriza por su estructura química, que incluye dos anillos fenilo y un grupo metilo unido al átomo de nitrógeno de la estructura base de la difenhidramina. Esta modificación mejora sus efectos farmacológicos y altera su potencia y perfil de efectos secundarios en comparación con su compuesto original. La sustancia es típicamente un polvo cristalino blanco a blanco sucio, que exhibe baja solubilidad en agua pero mayor solubilidad en disolventes orgánicos. Su mecanismo de acción implica el antagonismo del receptor H1 de histamina, lo que ayuda a aliviar los síntomas de reacciones alérgicas, como picazón y secreción nasal. Además, debido a sus efectos sedantes, a veces se utiliza en ayudas para dormir de venta libre. Los perfiles de seguridad y eficacia son consideraciones importantes, como con cualquier medicamento, y los efectos secundarios potenciales pueden incluir somnolencia, boca seca y mareos. Al igual que con todos los fármacos, la dosis adecuada y la orientación médica son esenciales para un uso seguro.

Fórmula: C₁₈H₂₃NO

InChI: InChI=1S/C18H23NO/c1-15-9-11-17(12-10-15)18(20-14-13-19(2)3)16-7-5-4-6-8-16/h4-12,18H,13-14H2,1-3H3

Clave InChI: InChIKey=PJUYQWIDNIAHIZ-UHFFFAOYSA-N

SMILES: C(OCCN(C)C)(C1=CC=C(C)C=C1)C2=CC=CC=C2

Sinónimos:

• 2-((p-Methyl-alpha-phenylbenzyl)oxy)ethyl(dimethyl)amine
• 4-Methyldiphenhydramine
• Ethanamine, N,N-dimethyl-2-[(4-methylphenyl)phenylmethoxy]-
• Ethylamine, N,N-dimethyl-2-[(p-methyl-α-phenylbenzyl)oxy]-
• N,N-Dimethyl-2-[(4-methylphenyl)phenylmethoxy]ethanamine
• N,N-Dimethyl-N-[2-(p-methyl-α-phenylbenzyloxy)ethyl]amine
• N,N-dimethyl-2-[(4-methylphenyl)(phenyl)methoxy]ethanamine
• Toladryl
• p-Methylbenzhydryl 2-dimethylaminoethyl ether
• p-Methyldiphenhydramine

Orphenadrine Related Compound F (N,N-Dimethyl-2-[phenyl(p-tolyl)methoxy]ethanamine citrate)

CAS: 19804-27-4

Amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters, salts thereof, nesoi

Fórmula: C₁₈H₂₃NO·C₆H₈O₇

Forma y color: White Powder

Peso molecular: 461.20497

Ref: 45-1479064

Ethanamine, N,N-dimethyl-2-[(4-methylphenyl)phenylmethoxy]-

CAS: 19804-27-4

Fórmula: C₁₈H₂₃NO

Pureza: 98%

Forma y color: Liquid

Peso molecular: 269.3813

Ref: IN-DA002B92

N,N-Dimethyl-2-(phenyl(p-tolyl)methoxy)ethanamine

CAS: 19804-27-4

N,N-Dimethyl-2-(phenyl(p-tolyl)methoxy)ethanamine

Pureza: 98%

Peso molecular: 269.39g/mol

Ref: 54-OR1067626

Toladryl (Diphenhydramine EP Impurity B, Dimenhydrinate EP Impurity G, Orphenadrine EP Impurity F, Orphenadrine USP Related Compound F (Free Form))

CAS: 19804-27-4

Fórmula: C₁₈H₂₃NO

Peso molecular: 269.39

Ref: 4Z-T-442001

Toladryl

Producto controlado

CAS: 19804-27-4

Applications A diphenhydramine (D486900) analog classified as an antihistaminic.
References Bakker, R.A. et al.: Mol. Pharm., 60, 1133 (2001); Rekker, R.F. et al.: Arzneim.-Forsch., 21, 688 (1971);

Fórmula: C₁₈H₂₃NO

Forma y color: Neat

Peso molecular: 269.38

Ref: TR-T530800

Diphenhydramine EP Impurity B

CAS: 19804-27-4

Fórmula: C₁₈H₂₃NO

Peso molecular: 269.38

Ref: ST-EA-CP-D23002

Toladryl

Producto controlado

CAS: 19804-27-4

Toladryl is a histamine receptor antagonist used to treat allergies and hay fever. It blocks the H1 histamine receptors in the body, preventing them from binding with histamine and causing allergic reactions. Toladryl also has a role in lowering blood pressure by blocking the alpha-1 adrenergic receptors, which are responsible for vasoconstriction. This drug is an aziridine derivative that has been synthesized using an asymmetric synthesis process. It has been shown to be effective in spastic conditions, such as multiple sclerosis, because it inhibits the transfer of potassium ions across nerve cells.

Fórmula: C₁₈H₂₃NO

Pureza: Min. 95%

Peso molecular: 269.38 g/mol

Ref: 3D-FT28302

Toladryl

CAS: 19804-27-4

Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral activity, with antihistamine and anticholinergic properties. Its anticholinergic effects are approximately a tenth of those seen with Diphenhydramine, yet it offers 2-4 times the protection against lethal doses of histamine in guinea pigs. The side effects of Toladryl are fewer and milder compared to Diphenhydramine; however, at higher doses, it may cause symptoms such as insomnia, agitation, and disorientation related to the central nervous system. Toladryl is utilized in the research of allergic diseases.

Fórmula: C₁₈H₂₃NO

Forma y color: Solid

Peso molecular: 269.38

Ref: TM-T200797