CAS 2002-29-1

Pivalato de flumetasona

Descripción:

Pivalato de flumetasona es un corticosteroide sintético con propiedades antiinflamatorias e inmunosupresoras, utilizado principalmente en aplicaciones dermatológicas. Se caracteriza por su potente actividad glucocorticoide, que ayuda a reducir la inflamación y aliviar los síntomas asociados con diversas condiciones de la piel. La sustancia es un derivado de la flumetasona, modificado con un éster de pivalato, lo que mejora su lipofilia y penetración en la piel. Esta modificación permite una aplicación tópica efectiva, haciéndolo adecuado para tratar condiciones como eczema, psoriasis y dermatitis. Pivalato de flumetasona típicamente exhibe una baja absorción sistémica cuando se aplica tópicamente, minimizando los posibles efectos secundarios asociados con corticosteroides sistémicos. Su estructura química incluye un esqueleto esteroide, que es esencial para su actividad biológica, y a menudo se formula en cremas, ungüentos o lociones para facilitar su aplicación. Al igual que con todos los corticosteroides, su uso debe ser monitoreado para evitar posibles efectos secundarios, particularmente con el uso prolongado.

Fórmula: C₂₇H₃₆F₂O₆

InChI: InChI=1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1

Clave InChI: InChIKey=JWRMHDSINXPDHB-OJAGFMMFSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@@H](C)[C@@]2(C(COC(C(C)(C)C)=O)=O)O)[H]

Sinónimos:

• (6α,11β,16α)-21-(2,2-Dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 21-Pivalate De Flumetasone
• 21-Pivalato De Flumetasona
• 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-pivalate
• 6α,9α-Difluoro-16α-methylprednisolone 21-pivalate
• Flumetason-21-pivalat
• Flumetasone 21-Pivalate
• Flumetasone pivalate
• Flumethasone 21-pivalate
• Flumethasone pivalate
• Locacorten
• Locorten
• Lorinden
• Losalen
• Nsc 107680
• Pivalic acid, 21-ester with 6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-,
• Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-, 21-pivalate

FLUMETASONE PIVALATE FOR ID AND ASSAY CRS

CAS: 2002-29-1

FLUMETASONE PIVALATE FOR ID AND ASSAY CRS

Ref: 41-Y0002494

FLUMETASONE PIVALATE CRS

CAS: 2002-29-1

FLUMETASONE PIVALATE CRS

Fórmula: C₂₇H₃₆F₂O₆

Forma y color: Added Modified

Peso molecular: 494.5679

Ref: 41-F0188500

Flumetasone pivalate

CAS: 2002-29-1

Flumetasone pivalate

Fórmula: C₂₇H₃₆F₂O₆

Pureza: 99.9%

Forma y color: Off-White

Peso molecular: 494.248

Ref: 47-1156

Flumethasone pivalate

CAS: 2002-29-1

Flumethasone pivalate

Pureza: ≥98%

Peso molecular: 494.57g/mol

Ref: 54-BUP15575

Flumetasone Pivalate

CAS: 2002-29-1

Forma y color: Neat

Ref: 86-MM0427.00

Flumethasone pivalate

Producto controlado

CAS: 2002-29-1

Fórmula: C₂₇H₃₆F₂O₆

Forma y color: Neat

Peso molecular: 494.57

Ref: 04-C13718600

Flumethasone 21-Pivalate

CAS: 2002-29-1

Applications An anti-inflammatory anti-itching corticosteroid found in topical creams.
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Hoeller, S., et al.: J. Pharm. Sci., 98, 2686 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Fórmula: C₂₇H₃₆F₂O₆

Forma y color: Neat

Peso molecular: 494.57

Ref: TR-F455015

Flumethasone 21-Pivalate-d3

Producto controlado

CAS: 2002-29-1

Fórmula: C₂₇D₃H₃₃F₂O₆

Forma y color: Neat

Peso molecular: 497.586

Ref: TR-F455017

Flumethasone 21-pivalate

Producto controlado

CAS: 2002-29-1

Flumethasone 21-pivalate (FP) is a synthetic glucocorticoid that binds to the glucocorticoid receptor and suppresses the immune system. FP has been used clinically for the treatment of inflammatory bowel disease and other conditions, such as allergic reactions, asthma, cancer, and skin disorders. The drug is also used to treat skin disorders in veterinary medicine. FP is only water-soluble at temperatures above its phase transition temperature. FP has been shown to inhibit the growth of cancer cells and growth factors by binding to toll-like receptors on cells. It has also been shown to have anti-inflammatory properties, which may be due to its ability to inhibit proinflammatory cytokines such as TNF-α or IL-6.

Fórmula: C₂₇H₃₆F₂O₆

Pureza: Min. 95%

Peso molecular: 494.57 g/mol

Ref: 3D-FF23329

Flumethasone pivalate

CAS: 2002-29-1

Flumethasone pivalate: antipruritic, anti-inflammatory, and vasoconstrictor; for adrenocortical suppression, skin atrophy, and telangiectasia studies.

Fórmula: C₂₇H₃₆F₂O₆

Pureza: 99.57% - 99.95%

Forma y color: Solid

Peso molecular: 494.57

Ref: TM-T20802

Flumetasone Pivalate

CAS: 2002-29-1

Fórmula: C₂₇H₃₆F₂O₆

Peso molecular: 494.6

Ref: ST-EA-CP-F28017