CAS 2018-66-8

Benzyloxi-carbonil-L-leucina

Descripción:

Benzyloxi-carbonil-L-leucina, comúnmente conocido como Z-Leu, es un derivado del aminoácido leucina, caracterizado por la presencia de un grupo protector benzyloxycarbonilo (Z). Este compuesto se utiliza típicamente en la síntesis de péptidos como un grupo protector para el grupo amino de la leucina, facilitando la formación de enlaces peptídicos sin interferencia del grupo amino. Z-Leu es un sólido cristalino blanco a blanco sucio, y es soluble en disolventes orgánicos como el metanol y el dimetilsulfóxido, pero tiene una solubilidad limitada en agua. La presencia del grupo benzyloxycarbonilo mejora la estabilidad del aminoácido durante las reacciones químicas, lo que lo convierte en un intermediario valioso en la síntesis de péptidos y proteínas más complejas. Además, Z-Leu puede ser desprotegido bajo condiciones específicas, permitiendo la regeneración del grupo amino libre para reacciones posteriores. Su número CAS, 2018-66-8, se utiliza para la identificación en bases de datos químicas y contextos regulatorios. En general, Benzyloxi-carbonil-L-leucina desempeña un papel significativo en la química orgánica y la bioquímica, particularmente en el campo de la síntesis de péptidos.

Fórmula: C₁₄H₁₉NO₄

InChI: InChI=1S/C14H19NO4/c1-10(2)8-12(13(16)17)15-14(18)19-9-11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3,(H,15,18)(H,16,17)/t12-/m0/s1

Clave InChI: InChIKey=USPFMEKVPDBMCG-LBPRGKRZSA-N

SMILES: C(OC(N[C@@H](CC(C)C)C(O)=O)=O)C1=CC=CC=C1

Sinónimos:

• (2S)-2-[[(Benzyloxy)carbonyl]amino]-4-methylpentanoic acid
• (2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoate
• (2S)-4-Methyl-2-(phenylmethoxycarbonylamino)pentanoic acid
• (Benzyloxycarbonyl)leucine
• (Carbobenzoxy)leucine
• (Carbobenzyloxy)-<span class="text-smallcaps">L</span>-leucine
• <span class="text-smallcaps">L</span>-(Carbobenzyloxy)leucine
• <span class="text-smallcaps">L</span>-Leucine, N-[(phenylmethoxy)carbonyl]-
• <span class="text-smallcaps">L</span>-N-(Benzyloxycarbonyl)leucine
• Benzyloxycarbonyl-<span class="text-smallcaps">L</span>-leucine
• CBZ-<span class="text-smallcaps">L</span>-leucine
• Carbobenzoxy-<span class="text-smallcaps">L</span>-leucine
• Cbz-L-leucine
• Leucine, N-carboxy-, N-benzyl ester
• Leucine, N-carboxy-, N-benzyl ester, <span class="text-smallcaps">L</span>-
• N-(Benzyloxycarbonyl)-<span class="text-smallcaps">L</span>-leucine
• N-(Benzyloxycarbonyl)leucine
• N-(Carbobenzoxy)leucine
• N-Carbobenzoxy-<span class="text-smallcaps">L</span>-leucine
• N-Carbobenzyloxy-<span class="text-smallcaps">L</span>-leucine
• N-Carboxy-<span class="text-smallcaps">L</span>-leucine N-benzyl ester
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-leucine
• N-[(benzyloxy)carbonyl]-D-leucine
• N-[(benzyloxy)carbonyl]-L-leucine
• N-[(benzyloxy)carbonyl]leucine
• N-cbz-l-leucine
• NSC 60039
• Nα-Benzyloxycarbonyl-L-leucine
• Z-Leu-OH
• z-Leu
• L-Leucine, N-[(phenylmethoxy)carbonyl]-
• Leucine, N-carboxy-, N-benzyl ester, L-
• N-[(Phenylmethoxy)carbonyl]-L-leucine

N-Benzyloxycarbonyl-L-leucine

CAS: 2018-66-8

Fórmula: C₁₄H₁₉NO₄

Pureza: >96.0%(T)

Forma y color: Colorless to Light yellow clear liquid

Peso molecular: 265.31

Ref: 3B-C0739

Z-Leu-OH (oil)

CAS: 2018-66-8

Bachem ID: 4000522.

Fórmula: C₁₄H₁₉NO₄

Pureza: > 98%

Forma y color: White Oily

Peso molecular: 265.31

Ref: 01-4000522

N-Carbobenzyloxy-L-leucine

CAS: 2018-66-8

Fórmula: C₁₄H₁₉NO₄

Pureza: 95%

Forma y color: Solid

Peso molecular: 265.3050

Ref: IN-DA0035DD

N-Cbz-L-Leucine

CAS: 2018-66-8

N-Cbz-L-Leucine

Pureza: ≥98%

Peso molecular: 265.3g/mol

Ref: 54-BUP19528

N-Cbz-L-Leucine

CAS: 2018-66-8

N-Cbz-L-Leucine

Pureza: 98%

Peso molecular: 265.3g/mol

Ref: 54-OR1029931

Z-Leu-OH

CAS: 2018-66-8

Fórmula: C₁₄H₁₉NO₄

Pureza: ≥ 96.0%

Forma y color: Light yellow liquid

Peso molecular: 265.30

Ref: 7W-GM9292

N-Cbz-L-Leucine

CAS: 2018-66-8

N-Cbz-L-Leucine (N-[(Phenylmethoxy)carbonyl]-L-leucine) is a leucine derivative, a commonly used amino acid protecting group.

Fórmula: C₁₄H₁₉NO₄

Pureza: 99.59%

Forma y color: Solid

Peso molecular: 265.3

Ref: TM-T64400

N-Benzyloxycarbonyl-L-leucine

CAS: 2018-66-8

N-Benzyloxycarbonyl-L-leucine is a peptidomimetic that has been shown to be effective against P. aeruginosa. The peptidyl amino group has a nucleophilic character, which allows it to react with the carboxyl group of L-lysine and form an amide bond. N-Benzyloxycarbonyl-L-leucine was found to be effective at low doses in inhibiting the growth of P. aeruginosa, and may also have therapeutic potential for treating lymphocytic leukemia. This compound is racemized into its two stereoisomers, D-N-benzyloxycarbonyl-L-leucine and L-N-benzyloxycarbonyl-L-leucine, which have different effects on cell membranes.

Fórmula: C₁₄H₁₉NO₄

Pureza: Min. 98 Area-%

Forma y color: Clear Liquid

Peso molecular: 265.31 g/mol

Ref: 3D-FB36690

Z-L-Leucine extrapure, 98%

CAS: 2018-66-8

Fórmula: C₁₄H₁₉NO₄

Pureza: min. 98%

Forma y color: Clear, Colourless to pale yellow, Viscous liquid

Peso molecular: 265.30

Ref: SR-85612

Cbz-Leucine

CAS: 2018-66-8

Fórmula: C₁₄H₁₉NO₄

Pureza: 95%

Forma y color: Liquid

Peso molecular: 265.309

Ref: 10-F032700

N-Cbz-L-leucine

Producto controlado

CAS: 2018-66-8

Applications N-Cbz-L-Leucine is an N-Cbz-protected form of L-Leucine (L330110). L-Leucine is an essential amino acid that induces a sharp decrease in blood glucose levels in individuals with idiopathic familial hypoglycemia, but has no known effects on normal, healthy individuals. L-Leucine also acts as an Isoleucine (I820210) antagonist in the rat, causing delays in growth, and is a potential tumour promoter of bladder cancer.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fajans, S., et al.: J. Clin. Inv., 42, 216 (1963); Harper, A., et al.: Arch. Biochem. Biophys., 57, 1 (1955); Nishio, Y., et al.: Science, 231, 843 (1986)

Fórmula: C₁₄H₁₉NO₄

Forma y color: Neat

Peso molecular: 265.30

Ref: TR-C227760