CAS 20311-51-7

Solamargina

Descripción:

Solamargina es un compuesto de glicoalcaloide que se encuentra principalmente en plantas de la familia Solanaceae, particularmente en especies como Solanum tuberosum (patata) y Solanum melongena (berenjena). Se caracteriza por su estructura compleja, que incluye un esqueleto esteroidal y una porción de azúcar, típicamente una unidad de rhamnosa. Solamargina exhibe diversas actividades biológicas, incluyendo propiedades potenciales anti-cancerígenas, antiinflamatorias y antimicrobianas, lo que lo convierte en un tema de interés en la investigación farmacológica. Se conoce que el compuesto es tóxico a concentraciones más altas, lo que puede llevar a síntomas como malestar gastrointestinal. Su mecanismo de acción a menudo implica la interrupción de las membranas celulares y la interferencia con las vías de señalización celular. Debido a su naturaleza dual como compuesto bioactivo y potencial toxina, la presencia de Solamargina en fuentes alimenticias requiere una cuidadosa consideración respecto a su concentración y efectos en la salud humana. A medida que la investigación continúa, Solamargina puede ofrecer perspectivas sobre nuevas avenidas terapéuticas mientras destaca la importancia de comprender los compuestos derivados de plantas en la nutrición y la medicina.

Fórmula: C₄₅H₇₃NO₁₅

InChI: InChI=1S/C45H73NO15/c1-19-9-14-45(46-17-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(53)34(51)32(49)22(4)56-41)37(54)38(29(18-47)58-42)59-40-35(52)33(50)31(48)21(3)55-40/h7,19-22,24-42,46-54H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1

Clave InChI: InChIKey=MBWUSSKCCUMJHO-ZGXDEBHDSA-N

SMILES: C[C@@]12[C@@]3([C@](C[C@]1([C@]4([C@](CC2)([C@]5(C)C(=CC4)C[C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7)[C@@H](O)[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](CO)O6)CC5)[H])[H])[H])(O[C@@]9([C@H]3C)CC[C@@H](C)CN9)[H])[H]

Sinónimos:

• (3beta,22alpha,25R)-Spirosol-5-en-3-yl 6-deoxy-alpha-L-mannopyranosyl-(1->2)-[6-deoxy-alpha-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside
• (3beta,22alpha,25R)-spirosol-5-en-3-yl 6-deoxy-alpha-L-mannopyranosyl-(1->2)-[6-deoxy-beta-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside
• (3beta,22alpha,25R)-spirosol-5-en-3-yl 6-deoxyhexopyranosyl-(1->2)-[6-deoxyhexopyranosyl-(1->4)]hexopyranoside
• (3β,22α,25R)-Spirosol-5-en-3-yl O-6-deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl-(1→2)-O-[6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→4)]-β-<smallcap>D</span>-glucopyranoside
• NSC 407810
• Solamargin
• Solamargine
• beta-D-glucopyranoside, (3beta,22alpha,25R)-spirosol-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1->4)]-
• beta-D-glucopyranoside, (3beta,22alpha,25R)-spirosol-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-[6-deoxy-beta-L-mannopyranosyl-(1->4)]-
• α-Solamargine
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,22α,25R)-spirosol-5-en-3-yl O-6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→2)-O-[6-deoxy-α-<smallcap>L</span>-mannopyranosyl-(1→4)]-
• δ-Solanigrine
• (3β,22α,25R)-Spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside

α-Solamargine

CAS: 20311-51-7

alpha-Solamargine analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₄₅H₇₃NO₁₅

Pureza: (HPLC) ≥98%

Forma y color: Powder

Peso molecular: 868.08

Ref: 11-1653S

Solamargine

CAS: 20311-51-7

Fórmula: C₄₅H₇₃NO₁₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 868.0588

Ref: IN-DA00BF6H

Solamargine

CAS: 20311-51-7

Solamargine

Pureza: ≥98%

Peso molecular: 868.06g/mol

Ref: 54-BUP05239

(2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-Hydroxy-2-(Hydroxymethyl)-6-(((2'R,4S,5'R,6Ar,6Bs,8As,8Br,9S,11As,12As,12Bs)-5',6A,8A,9-Tetramethyl-1,3,4,5,6,6A,6B,7,8,8A,8B,9,11A,12,12

CAS: 20311-51-7

(2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3S,4S,5R,6R)-4-Hydroxy-2-(Hydroxymethyl)-6-(((2'R,4S,5'R,6Ar,6Bs,8As,8Br,9S,11As,12As,12Bs)-5',6A,8A,9-Tetramethyl-1,3,4,5,6,6A,6B,7,8,8A,8B,9,11A,12,12

Pureza: ≥98%

Peso molecular: 868.06g/mol

Ref: 54-OR1026221

Solamargine

CAS: 20311-51-7

Fórmula: C₄₅H₇₃NO₁₅

Peso molecular: 868.07

Ref: 7W-GY9459

Solamargine

CAS: 20311-51-7

Fórmula: C₄₅H₇₃NO₁₅

Pureza: 95%~99%

Peso molecular: 868.071

Ref: BP-BP1320

Solamargine

CAS: 20311-51-7

Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.

Fórmula: C₄₅H₇₃NO₁₅

Pureza: 99.17% - 99.96%

Forma y color: Solid

Peso molecular: 868.06

Ref: TM-T4034

Α-solamargine

CAS: 20311-51-7

Natural alkaloid

Fórmula: C₄₅H₇₃NO₁₅

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 868.08

Ref: 5G-83270

a-Solamargine

CAS: 20311-51-7

This compound is a cytotoxic glycoalkaloid and a commonly found secondary metabolite in the plants of the genus Solanum. Solamargine penetrates cell membrane, inhibits growth of tumoral cell lines and induces apoptosis at low micromolar concentrations. It also sensitises cancer cell lines to the treatment with chemotherapeutic agents, such as cisplatin, epirubicin and trastuzumab. The compound was seen to inhibit P-glycoprotein in neuroblastoma cell line.

Fórmula: C₄₅H₇₃NO₁₅

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 868.06 g/mol

Ref: 3D-OS65545

a-Solamargine extrapure, 98%

CAS: 20311-51-7

Fórmula: C₄₅H₇₃NO₁₅

Pureza: min. 98%

Forma y color: White to beige, Powder

Peso molecular: 868.06

Ref: SR-99957

SOLAMARGINE

CAS: 20311-51-7

Pureza: ≥98%

Peso molecular: 868.0709839

Ref: 10-F808650

Alpha-Solamargine

CAS: 20311-51-7

Applications α-Solamargine is a steroidal glycosyl-alkaloid which displays inactivation of PI3-L/Akt and reduction for SP1 and p65 in the suppression of human lung cancer cells.
References Chen, Y. et al.L J. Exp. Clin. Canc. Res., 34, 154 (2015);

Fórmula: C₄₅H₇₃NO₁₅

Forma y color: Neat

Peso molecular: 868.06

Ref: TR-S676518