CAS 203120-17-6

Laninamivir

Descripción:

Laninamivir es un compuesto antiviral utilizado principalmente en el tratamiento de la influenza. Pertenece a la clase de inhibidores de la neuraminidasa, que funcionan bloqueando la enzima viral neuraminidasa, evitando así la liberación de nuevas partículas virales de las células infectadas y limitando la propagación del virus en el tracto respiratorio. Laninamivir se caracteriza por su larga vida media, lo que permite una dosificación menos frecuente en comparación con otros medicamentos antivirales. Se administra típicamente por inhalación, lo que facilita la entrega directa al sitio de infección en los pulmones. El compuesto ha demostrado eficacia contra varias cepas de influenza, incluidas aquellas resistentes a otros agentes antivirales. Además, Laninamivir tiene un perfil de seguridad favorable, con efectos secundarios comunes que son leves y transitorios. Sus propiedades farmacocinéticas únicas y su mecanismo de acción lo convierten en una opción valiosa en el manejo de la influenza, particularmente en poblaciones de alto riesgo de complicaciones por el virus.

Fórmula: C₁₃H₂₂N₄O₇

InChI: InChI=1S/C13H22N4O7/c1-5(19)16-9-6(17-13(14)15)3-8(12(21)22)24-11(9)10(23-2)7(20)4-18/h3,6-7,9-11,18,20H,4H2,1-2H3,(H,16,19)(H,21,22)(H4,14,15,17)/t6-,7+,9+,10+,11+/m0/s1

Clave InChI: InChIKey=QNRRHYPPQFELSF-CNYIRLTGSA-N

SMILES: [C@H]([C@@H](CO)O)(OC)[C@]1([C@H](NC(C)=O)[C@@H](NC(=N)N)C=C(C(O)=O)O1)[H]

Sinónimos:

• (4S,5R,6R)-5-Acetamido-4-carbamimidamido-6-((1R,2R)-3-hydroxy-2-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid
• (4S,5R,6R)-5-Acetamido-4-guanidino-6-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid
• 203120-17-6
• 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-<span class="text-smallcaps">D</smallcap>-glycero-<smallcap>D</span>-galacto-non-2-enonic acid
• <span class="text-smallcaps">D</smallcap>-glycero-<smallcap>D</span>-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-
• Laninamivir
• R 125489
• D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-
• 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid

D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-

CAS: 203120-17-6

Fórmula: C₁₃H₂₂N₄O₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 346.3364

Ref: IN-DA0028OB

Laninamivir

CAS: 203120-17-6

Laninamivir (R 125489) inhibits influenza NA (IC50: 0.90-3.12 nM) across strains H12N5, pH1N1, and H2N2.

Fórmula: C₁₃H₂₂N₄O₇

Pureza: 99%

Forma y color: Solid

Peso molecular: 346.34

Ref: TM-T15707

(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-Dihydroxy-1-Methoxypropyl)-4-Guanidino-3,4-Dihydro-2H-Pyran-6-Carboxylic Acid

CAS: 203120-17-6

(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-Dihydroxy-1-Methoxypropyl)-4-Guanidino-3,4-Dihydro-2H-Pyran-6-Carboxylic Acid

Pureza: 98%

Peso molecular: 346.34g/mol

Ref: 54-OR1024357

Laninamivir

CAS: 203120-17-6

Laninamivir

Pureza: ≥98%

Peso molecular: 346.34g/mol

Ref: 54-BUP02004

Laninamivir

CAS: 203120-17-6

Fórmula: C₁₃H₂₂N₄O₇

Peso molecular: 346.34

Ref: 4Z-L-222001

Laninamivir

CAS: 203120-17-6

Applications A new potent neuraminidase (NA) inhibitor, shows long-acting anti-influenza virus activity.
References Bantia, S., et al.: Antimicrob. Agents Chemother., 42, 801 (1998), Honda, T., et al.: Bioorg. Med. Chem. Lett., 12, 1925 (2002), Kiso, M., et al.: Lancet, 364, 759 (2004), Macdonald, S., et al.: J. Med. Chem., 48, 2964 (2005),

Fórmula: C₁₃H₂₂N₄O₇

Forma y color: White To Off-White

Peso molecular: 346.34

Ref: TR-L174000

(2R,3R,4S)-3-Acetamido-2-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-4-guanidino-3,4-dihydro-2H-pyran-6-carboxylic acid

CAS: 203120-17-6

Fórmula: C₁₃H₂₂N₄O₇

Pureza: 98%

Peso molecular: 346.34

Ref: 10-F549638

Laninamivir-13C,15N2

Producto controlado

CAS: 203120-17-6

Applications Isotope labelled Laninamir (L174000) is a new potent neuraminidase (NA) inhibitor, shows long-acting anti-influenza virus activity.
References Bantia, S., et al.: Antimicrob. Agents Chemother., 42, 801 (1998), Honda, T., et al.: Bioorg. Med. Chem. Lett., 12, 1925 (2002), Kiso, M., et al.: Lancet, 364, 759 (2004), Macdonald, S., et al.: J. Med. Chem., 48, 2964 (2005),

Fórmula: C₁₃H₂₂N₄O₇

Forma y color: Neat

Peso molecular: 346.34

Ref: TR-L174003

Laninamivir

CAS: 203120-17-6

Laninamivir is an antiviral drug that inhibits the neuraminidase activity of influenza A and B viruses. It is a prodrug that is activated by esterases to form the active metabolite laninamivir carboxylate, which inhibits virus replication. Laninamivir has been shown to be effective against oseltamivir-resistant mutants and has been used in combination with oseltamivir as a treatment for pandemic influenza. Laninamivir has also been studied in pediatric patients with influenza-like symptoms, with significant reductions in symptom severity, duration of symptoms, and viral load.

Fórmula: C₁₃H₂₂N₄O₇

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 346.34 g/mol

Ref: 3D-ML58733