CAS 20449-79-0

Melitina

Descripción:

Melitina es un péptido derivado del veneno de las abejas melíferas (Apis mellifera) y es conocido por su potente actividad biológica. Consiste en 26 aminoácidos y tiene un peso molecular de aproximadamente 2846 Da. Melitina se caracteriza por su naturaleza anfipática, lo que le permite interactuar con membranas lipídicas, provocando la disrupción de la membrana y la lisis celular. Esta propiedad lo convierte en un tema de interés en varios campos, incluida la inmunología y la investigación del cáncer, ya que exhibe actividades antimicrobianas y anticancerígenas. Además, Melitina puede inducir inflamación y se ha estudiado por sus posibles aplicaciones terapéuticas, aunque sus efectos citotóxicos requieren una cuidadosa consideración en el uso médico. El péptido es soluble en agua y presenta una estructura helicoidal en entornos de membrana, lo que contribuye a su capacidad para formar poros en las bicapas lipídicas. En general, Melitina sirve como un modelo valioso para comprender las interacciones péptido-membrana y tiene potencial para desarrollar nuevos agentes terapéuticos.

Fórmula: C₁₃₁H₂₂₉N₃₉O₃₁

InChI: InChI=1/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)/t71-,72-,73-,74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-,104-,105-,106-/m0/s1

Sinónimos:

• H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
• Melittin From Bee Venom Sequencing*Grade
• Beevenommelittin

Melittin

CAS: 20449-79-0

Synthetic melittin, the main component of the honeybee venom. The amphiphilic nature of this antimicrobial peptide makes it a excellent model compound for monitoring lipid-protein interactions in membranes. Adade et al. observed that melittin peptide could kill Trypanosoma cruzi parasites by inducing different cell death pathways.

Fórmula: C₁₃₁H₂₂₉N₃₉O₃₁

Pureza: 98.5%

Forma y color: White

Peso molecular: 2846.5

Ref: 01-4030808

Melittin

CAS: 20449-79-0

Melittin

Pureza: 98%

Peso molecular: 2,846.46g/mol

Ref: 54-BIM0170

Melittin

CAS: 20449-79-0

Fórmula: C₁₃₁H₂₂₉N₃₉O₃₁

Pureza: ≥ 97.0%

Forma y color: White to faint yellow or faint tan powder

Peso molecular: 2846.46

Ref: 7W-GK3910

Melittin

CAS: 20449-79-0

Melittin: principal bee venom toxin, 26 amino acids, activates low-weight PLA2, not high-weight PLA2.

Fórmula: C₁₃₁H₂₂₉N₃₉O₃₁

Pureza: 98.37% - 99.92%

Forma y color: Solid

Peso molecular: 2846.46

Ref: TM-TP1299

Melittin - 95%

CAS: 20449-79-0

Apitherapy (the use of honey bee products in alternative medicine) is an emerging field, with a long history of unsupported health benefits, particularly in cancer. Components of bee venom have been demonstrated to have antitumoral effects in various cancers. For example, honey bee venom (XM176021) was shown to reduce metastases of breast cancer to the lungs and inhibit tumour growth (Orsolić, et al., 2003). Similarly, the active component of bee venom, a peptide called melittin (FM10065), showed anticancer selectivity through undefined molecular mechanisms and suggests novel treatment strategies for aggressive breast cancers (Duffy, et al., 2020).

Fórmula: C₁₃₁H₂₂₉N₃₉O₃₁

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 2,846.47 g/mol

Ref: 3D-FM10065

Melittin

CAS: 20449-79-0

Melittin is a 26-residue peptide originally isolated from venom of the European honeybee. Melittin is a cationic, hemolytic peptide from honey bee venom. Melittin lowers the surface tension at the plasma membrane and causes cell lysis. Melittin exhibits potent anti-inflammatory and antimicrobial activity. Melittin has been extensively used as a model peptide for observing membrane lipid-protein interactions.

Fórmula: C₁₃₁H₂₂₉N₃₉O₃₁

Forma y color: Powder

Peso molecular: 2,846.47 g/mol

Ref: 3D-CRB1000015

Melittin, 70%

CAS: 20449-79-0

Apitherapy (the use of honey bee products in alternative medicine) is an emerging field, with a long history of unsupported health benefits, particularly in cancer. Components of bee venom have been demonstrated to have antitumoral effects in various cancers. For example, honey bee venom (XM176021) was shown to reduce metastases of breast cancer to the lungs and inhibit tumour growth (Orsolić, et al., 2003). Similarly, the active component of bee venom, a peptide called melittin (FM10065), showed anticancer selectivity through undefined molecular mechanisms and suggests novel treatment strategies for aggressive breast cancers (Duffy, et al., 2020).

Fórmula: C₁₃₁H₂₂₉N₃₉O₃₁

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 2,846.46 g/mol

Ref: 3D-XM176021

Melittin

CAS: 20449-79-0

Melittin is a major component of bee venom that has been shown to have antibacterial efficacy against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. It also demonstrates anti-viral activity, for example it inhibits human immunodeficiency virus and herpes simplex virus. Furthermore it can be used in the treatment of inflammatory-related illnesses due to it inhibiting the phospholipase A2 enzyme. In addition to this Melittin's abaility to inhibit inflammatory mediators such as nitric oxide and cyclooxygenase-2 aids in the treatment of inflammatory diseases. As a result of Melittin having the capabilities of attacking lipid membranes and it surpressing COX-2 mRNA expression it can also be used in the treatment of tumours. The bound form of melittin is not toxic to mammalian cells, but it is toxic when it is released into the cell cytoplasm. Melittin has been shown to inhibit transcriptional regulation and locomotor activity in mice. This may be due to its ability to bind DNA, preventing transcription and translation of certain genes. Lastly It has strong hemolytic activity and been seen to increase insulin secretion via depolarization of pancreatic beta-cells. Melittin is a diverse peptide which can be used ina whole spectrum of research and therapeutic areas.

Fórmula: C₁₃₁H₂₂₉N₃₉O₃₁

Pureza: Min. 95%

Peso molecular: 2,846.47 g/mol

Ref: 3D-TOX-70001-PI