CAS 20623-13-6

nitritocobalamina

Descripción:

nitritocobalamina, con el número CAS 20623-13-6, es un derivado de la cobalamina, comúnmente conocida como vitamina B12. Este compuesto presenta un grupo nitrito (-ONO) unido al centro de cobalto de la estructura de la cobalamina, que es esencial para diversas funciones biológicas. nitritocobalamina se caracteriza por su compleja química de coordinación, donde el cobalto puede existir en diferentes estados de oxidación, influyendo en su reactividad y actividad biológica. Típicamente es un sólido cristalino de color rojo-púrpura, soluble en agua, y exhibe estabilidad bajo ciertas condiciones. La presencia del grupo nitrito puede afectar su interacción con moléculas biológicas y su biodisponibilidad general. Mientras que la cobalamina es crucial para la síntesis de ADN y la formación de glóbulos rojos, los roles biológicos específicos de nitritocobalamina y sus posibles aplicaciones en medicina o bioquímica están menos estudiados. Al igual que muchos derivados de la cobalamina, puede tener implicaciones en la investigación relacionada con la catálisis enzimática y las vías metabólicas. En general, nitritocobalamina representa un área de estudio interesante dentro del contexto más amplio de la química de la vitamina B12.

Fórmula: C₆₂H₈₈CoN₁₃O₁₄P·NO₂

InChI: InChI=1/C62H90N13O14P.Co.HNO2/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;2-1-3/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;(H,2,3)/q;+3;/p-3

Clave InChI: InChIKey=UUWYBLVKLIHDAU-UHFFFAOYSA-K

SMILES: [O-](N=O)[Co+3]1234[N]=5C6(C)C7[N-]1C(C(C)(C7CC(N)=O)CCC(=O)NCC(C)OP(=O)([O-])OC8C(O)C(N9C=[N]2C=%10C9=CC(C)=C(C)C%10)OC8CO)=C(C)C%11=[N]3C(=CC%12=[N]4C(=C(C)C5C(CCC(N)=O)C6(CC(N)=O)C)C(CC(N)=O)(C)C%12CCC(N)=O)C(C)(C)C%11CCC(N)=O

Sinónimos:

• Cobalamin, nitro-
• Cobinamide, Co-(nitrito-κO)-, dihydrogen phosphate (ester), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN³)
• Cobinamide, hydroxide nitrite (salt), dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole
• Cobinamide, nitrite (salt), dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole
• Cobinamide, nitrite phosphate, 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosylbenzimidazole, inner salt
• Nitrocobalamin
• Vitamin B12c
• Vitamin B_12c
• Cobinamide, Co-(nitrito-κO)-, dihydrogen phosphate (ester), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3)
• Cobinamide, nitrite phosphate, 3′-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole, inner salt
• Cobinamide, nitrite (salt), dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole
• Cobinamide, hydroxide nitrite (salt), dihydrogen phosphate (ester), inner salt, 3′-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole
• Nitritocobalamin

Nitritocobalamin

CAS: 20623-13-6

Fórmula: C₆₂H₈₈CoN₁₃O₁₄P·NO₂

Peso molecular: 1329.38 46.01

Ref: 4Z-V-035004

Nitritocobalamin (>85% by HPLC)

Producto controlado

CAS: 20623-13-6

Applications Nitritocobalamin is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).
References Kaczka, E.A., et al.: Science, 112, 354 (1950); Friedrich, W., et al.: Vitamins, 837 (1988); Forsyth, J.C., et al.: Clin. Toxicol., 31, 277 (1993)

Fórmula: C₆₂H₈₈CoN₁₄O₁₆P

Pureza: >85% by HPLC

Forma y color: Neat

Peso molecular: 1375.35

Ref: TR-N490240

Nitritocobalamin

CAS: 20623-13-6

Nitritocobalamin is a crystalline cellulose that is used as a chinese herb. It has been shown to have beneficial effects on pancreatic function and fatty acid metabolism in humans. Nitritocobalamin also has the ability to reduce nitrite ions to nitric oxide, which is important for human liver health. Nitritocobalamin is also known for its ability to inhibit the production of low-density lipoprotein-cholesterol (LDL-C) and cell proliferation in cultured cells. The target enzyme nitrite reductase was found to be inhibited by nitritocobalamin in both rat liver and human liver cell lines. In addition, melaleuca alternifolia showed low expression of nitrite reductase, which may be due to inhibition by nitritocobalamin.

Fórmula: C₆₂H₈₈CoN₁₄O₁₆P

Pureza: 85%Min

Peso molecular: 1,375.35 g/mol

Ref: 3D-FN173311

Nitritocobalamin

CAS: 20623-13-6

Fórmula: C₆₂H₈₈CoN₁₃O₁₄PNO₂

Peso molecular: 1329.38 : 46.01

Ref: ST-EA-CP-H13002