CAS 206361-99-1

Darunavir

Descripción:

Darunavir es un medicamento antirretroviral que se utiliza principalmente en el tratamiento del VIH/SIDA. Pertenece a la clase de fármacos conocidos como inhibidores de la proteasa, que actúan inhibiendo la enzima proteasa, crucial para el proceso de replicación viral. Darunavir se caracteriza por su alta potencia contra cepas de VIH, incluidas aquellas resistentes a otros inhibidores de la proteasa. La fórmula química de Darunavir es C27H37N3O4S, y presenta un grupo sulfonamida, que contribuye a su actividad antiviral. La sustancia se administra típicamente en combinación con otros agentes antirretrovirales para mejorar la eficacia y reducir el riesgo de resistencia. Darunavir es conocido por su favorable perfil farmacocinético, lo que permite una dosificación una vez al día en muchos casos. Generalmente es bien tolerado, aunque puede causar efectos secundarios como trastornos gastrointestinales y posibles elevaciones de las enzimas hepáticas. Al igual que con todas las terapias antirretrovirales, es esencial monitorear las interacciones medicamentosas y la adherencia a los regímenes de tratamiento para obtener resultados óptimos en el manejo del VIH.

Fórmula: C₂₇H₃₇N₃O₇S

InChI: InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1

Clave InChI: InChIKey=CJBJHOAVZSMMDJ-HEXNFIEUSA-N

SMILES: O(C(N[C@H]([C@@H](CN(S(=O)(=O)C1=CC=C(N)C=C1)CC(C)C)O)CC2=CC=CC=C2)=O)[C@@H]3[C@]4([C@@](OC3)(OCC4)[H])[H]

Sinónimos:

• (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate
• (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
• Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester
• Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester
• Carbamic acid, [3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, hexahydrofuro[2,3-b]furan-3-yl ester, [3R-[3α(1S*,2R*),3aβ,6aβ]]-
• Darunavir & its intermediates
• Darunavir & its intermediates (R&D)
• Prezista
• TMC 114 (inhibitor)
• Tmc 114
• Tmc 41629
• Uic 94017

Darunavir

CAS: 206361-99-1

Fórmula: C₂₇H₃₇N₃O₇S

Forma y color: White To Off-White Solid

Peso molecular: 547.67

Ref: 4Z-D-371

Darunavir

CAS: 206361-99-1

Darunavir

Pureza: ≥98%

Peso molecular: 547.66g/mol

Ref: 54-BUP13325

Darunavir

CAS: 206361-99-1

Fórmula: C₂₇H₃₇N₃O₇S

Pureza: ≥ 98.0%

Forma y color: White to off-white powder or solid

Peso molecular: 547.66

Ref: 7W-GP5767

Darunavir

CAS: 206361-99-1

Darunavir

Pureza: 98%

Peso molecular: 547.66g/mol

Ref: 54-OR1027115

Darunavir

Producto controlado

CAS: 206361-99-1

Fórmula: C₂₇H₃₇N₃O₇S

Forma y color: Neat

Peso molecular: 547.66

Ref: 04-C11965000

Darunavir

CAS: 206361-99-1

Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS.

Fórmula: C₂₇H₃₇N₃O₇S

Pureza: 99.67% - 99.76%

Forma y color: White Amorphous Solid

Peso molecular: 547.66

Ref: TM-T2324

Darunavir

CAS: 206361-99-1

Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.
References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),

Fórmula: C₂₇H₃₇N₃O₇S

Forma y color: Beige

Peso molecular: 547.66

Ref: TR-D193500

Darunavir

CAS: 206361-99-1

Darunavir is a HIV-1 protease inhibitor used orally in the treatment of patients with multi-drug resistant HIV-1 infection (Ghosh, 2007). It has also been shown to be effective against other infectious diseases such as hepatitis C virus and SARS coronavirus. Metabolized by cytochrome P450 3A (CYP3A) isoenzymes, darunavir is often administered together with ritonavir that prolongs its bioavaiability, giving a terminal elimination half-life (t1/2) of 15 hours (Back, 2008). The effect of darunavir on natural compounds such as matrix proteins and toll-like receptor activity has also been studied via high performance liquid chromatography (HPLC) experiments.

Fórmula: C₂₇H₃₇N₃O₇S

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 547.66 g/mol

Ref: 3D-FH20801

Darunavir

CAS: 206361-99-1

Fórmula: C₂₇H₃₇N₃O₇S

Pureza: 98%

Forma y color: Liquid, No data available.

Peso molecular: 547.67

Ref: 10-F547231