CAS 2098-66-0

Ciprotérone

Descripción:

Ciprotérone es un antiandrógeno esteroidal sintético y progestágeno, utilizado principalmente en el tratamiento de condiciones relacionadas con niveles excesivos de andrógenos, como hirsutismo, acné y ciertos tipos de pérdida de cabello en mujeres. También se utiliza en terapia hormonal para mujeres transgénero y en el manejo del cáncer de próstata. Químicamente, Ciprotérone se caracteriza por su capacidad para inhibir la acción de los andrógenos bloqueando los receptores androgénicos y reduciendo la producción de testosterona. Tiene una fórmula molecular que incluye carbono, hidrógeno y oxígeno, y su estructura presenta un núcleo de ciclopentanoperhidrofenantreno típico de los compuestos esteroides. Ciprotérone se administra por vía oral o mediante inyección, y sus efectos farmacológicos incluyen propiedades antiandrogénicas, antiinflamatorias y progestacionales. Los efectos secundarios pueden incluir aumento de peso, cambios de humor y posibles impactos en la función hepática, lo que requiere monitoreo durante el tratamiento. En general, Ciprotérone es un compuesto significativo en endocrinología y salud reproductiva, demostrando la compleja interacción de hormonas en la fisiología humana.

Fórmula: C₂₂H₂₇ClO₃

InChI: InChI=1/C22H27ClO3/c1-11(24)22(26)7-5-14-12-9-18(23)17-10-19(25)13-8-16(13)21(17,3)15(12)4-6-20(14,22)2/h9-10,12-16,26H,4-8H2,1-3H3/t12?,13-,14?,15?,16?,20+,21+,22+/m1/s1

Clave InChI: InChIKey=DUSHUSLJJMDGTE-ZJPMUUANSA-N

SMILES: C[C@]12[C@@]3([C@@](C3)(C(=O)C=C1C(Cl)=C[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@@]5(C(C)=O)O)[H])[H])[H])[H])[H]

Sinónimos:

• (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
• (1R,7aR,8aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
• (1R,7aR,8bS,10aS)-1-acetyl-5-chloro-1-hydroxy-8b,10a-dimethyl-2,3,3a,3b,7a,8,8a,8b,8c,9,10,10a-dodecahydrocyclopenta[a]cyclopropa[g]phenanthren-7(1H)-one
• (1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3′H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione
• 1,2α-Methylene-6-chloro-⁶-17α-hydroxyprogesterone
• 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-
• 3′H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1,2-dihydro-17-hydroxy-, (1β,2β)-
• 3′H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1β,2β-dihydro-17-hydroxy-
• 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron
• 6-Chlor-delta(sup 6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron [German]
• 6-Chloro-1,2α-methylene-4,6-pregnadien-17α-ol-3,20-dione
• 6-Chloro-17-hydroxy-1α,2α-methylenepregna-4,6-diene-3,20-dione
• 6-Chloro-6-dehydro-17α-hydroxy-1,2α-methyleneprogesterone
• Bay 94-8367
• Bay94-8367
• Ciproterona
• Ciproterona [INN-Spanish]
• Ciproterone
• Ciproterone [DCIT]
• Cyproteron
• Cyproterone [INN:BAN]
• Cyproteronum
• Cyproteronum [INN-Latin]
• Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1α,2α-methylene-
• Sh 80881
• Sh 881
• Unii-E61Q31Ek2F
• Cyproterone
• Cyproterone USP/EP/BP
• 6-chloro-1b,2b-dihydro-17-hydroxy-3'h-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione
• Cyproterone Acetate IMpurity F (Cyproterone)
• Cyproterone Acetate EP Impurity F
• Cyproterone Acetate 427-51-0 /Base
• 6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron
• 6-Chloro-1β,2β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-4,6-diene-3,20-dione
• 3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1,2-dihydro-17-hydroxy-, (1β,2β)-
• Cyproterone Acetate Impurity 6（Cyproterone Acetate EP Impurity F）
• Cyproterone Acetate Impurity F
• (1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4
• Cyproterone-d5
• 1,2α-Methylene-6-chloro-6-17α-hydroxyprogesterone
• ro-17-hydroxy-
• 3’h-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione,6-chloro-1-beta,2-beta-dihyd
• Cyproterone Acetate EP Impurity F (Cyproterone)

Cyproterone Acetate EP Impurity F-d3 (Cyproterone-d3)

CAS: 2098-66-0

Fórmula: C₂₂H₂₄D₃ClO₃

Peso molecular: 377.92

Ref: 4Z-C-2819

Cyproterone Acetate EP Impurity F (Cyproterone)

CAS: 2098-66-0

Fórmula: C₂₂H₂₇ClO₃

Forma y color: Pale Yellow Solid

Peso molecular: 374.91

Ref: 4Z-C-281

Cyproterone Acetate EP Impurity D

CAS: 2098-66-0

Fórmula: C₂₄H₃₁ClO₅

Forma y color: Pale Yellow Solid

Peso molecular: 434.96

Ref: 4Z-C-2817

Cyproterone

Producto controlado

CAS: 2098-66-0

Fórmula: C₂₂H₂₇ClO₃

Forma y color: Neat

Peso molecular: 374.90

Ref: 04-C11917000

Cyproterone-d5

CAS: 2098-66-0

Fórmula: C₂₂H₂₂D₅ClO₃

Peso molecular: 379.94

Ref: 4Z-C-282

Cyproterone-d4

Producto controlado

CAS: 2098-66-0

Applications Labelled Cyproterone (C989090). An antiandrogen, suppresses Testosterone and its metabolites. Derivatives of Cyproterone are administered to patients suffering from hypersexuality and to help facilitate the sexual transformation of male-to-female transsexuals.
References Gracia, T., et al.: Toxicol. App. Pharmacol., 225, 142 (2007), Ahlin, G., et al.: J. Med. Chem., 51, 5932 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Bovee, T., et al.: J. Steroid Biochem. Mol. Biol., 118, 85 (2010),

Fórmula: C₂₂H₂₃D₄ClO₃

Forma y color: Neat

Peso molecular: 378.93

Ref: TR-C989092

Cyproterone

Producto controlado

CAS: 2098-66-0

Impurity Cyproterone Acetate EP Impurity F
Applications Cyproterone (Cyproterone Acetate EP Impurity F) is an antiandrogen, suppresses Testosterone and its metabolites. Derivatives of Cyproterone are administered to patients suffering from hypersexuality and to help facilitate the sexual transformation of male-to-female transsexuals.
References Gracia, T., et al.: Toxicol. App. Pharmacol., 225, 142 (2007), Ahlin, G., et al.: J. Med. Chem., 51, 5932 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Bovee, T., et al.: J. Steroid Biochem. Mol. Biol., 118, 85 (2010),

Fórmula: C₂₂H₂₇ClO₃

Forma y color: Off White Solid

Peso molecular: 374.9

Ref: TR-C989090

Cyproterone-13C2,d8

Producto controlado

CAS: 2098-66-0

Fórmula: C₂C₂₀D₈H₁₉ClO₃

Forma y color: Neat

Peso molecular: 384.936

Ref: TR-C989093

Cyproterone Acetate EP Impurity F

CAS: 2098-66-0

Fórmula: C₂₂H₂₇ClO₃

Peso molecular: 374.9

Ref: ST-EA-CP-C148017

Cyproterone

CAS: 2098-66-0

Cyproterone, an anti-androgen, treats female hirsutism and acne, and is used palliatively in prostate cancer.

Fórmula: C₂₂H₂₇ClO₃

Forma y color: Solid

Peso molecular: 374.9

Ref: TM-T21016

Cyproterone

Producto controlado

CAS: 2098-66-0

Cyproterone is a steroidal anti-androgen that is used in the treatment of prostate cancer and other diseases. Cyproterone acetate (CPA) is an ester prodrug of cyproterone, which has been used as a contraceptive for more than 25 years. It binds to cytoplasmic receptors, blocking the effects of androgens on these receptors. CPA also inhibits transcriptional regulation by reducing the basal level of androgen receptor expression in target tissues. Cyproterone acetate has been shown to inhibit the growth of breast cancer cells through its ability to bind to and activate growth factor-β1 (GF-β1). CPA also has been shown to have positive effects on energy metabolism by regulating the activity of enzymes in this process. Cyproterone acetate is not active against many Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA).

Fórmula: C₂₂H₂₇ClO₃

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 374.9 g/mol

Ref: 3D-FC20763