CAS 211364-69-1

ácido [2-(6-aminopurina-9-il)-1-metil-etoxi]metil-(isopropoxicarboniloximetoxi)fosfínico

Descripción:

La sustancia química conocida como ácido [2-(6-aminopurina-9-il)-1-metil-etoxi]metil-(isopropoxicarboniloximetoxi)fosfínico, con el número CAS 211364-69-1, es un derivado del ácido fosfónico que exhibe características típicas de los análogos de nucleósidos. Este compuesto presenta una estructura de base purínica, que es significativa para su potencial actividad biológica, particularmente en aplicaciones antivirales y anticancerígenas. La presencia del grupo ácido fosfínico sugiere que puede interactuar con sistemas biológicos imitando nucleótidos naturales, potencialmente inhibiendo enzimas involucradas en la síntesis de ácidos nucleicos. Los grupos etóxido e isopropóxido contribuyen a su solubilidad y estabilidad, que son cruciales para su eficacia en contextos terapéuticos. Además, el grupo amino en el anillo purínico puede mejorar su interacción con objetivos biológicos. En general, las características estructurales únicas de este compuesto lo posicionan como un candidato para una mayor investigación en química medicinal, particularmente en el desarrollo de agentes antivirales u otras aplicaciones terapéuticas.

Fórmula: C₁₄H₂₂N₅O₇P

InChI: InChI=1/C14H22N5O7P/c1-9(2)26-14(20)23-7-25-27(21,22)8-24-10(3)4-19-6-18-11-12(15)16-5-17-13(11)19/h5-6,9-10H,4,7-8H2,1-3H3,(H,21,22)(H2,15,16,17)

SMILES: CC(C)OC(=O)OCOP(=O)(COC(C)Cn1cnc2c(N)ncnc12)O

Sinónimos:

• Mono-POC Tenofovir
• ((((R)-1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methyl)(hydroxy)phosphoryloxy)Methyl isopropyl carbonate
• Mono-POC PMPA
• Tenofovirdisoproxil Impurity I
• 2,4,7-Trioxa-5-phosphanonanoic acid, 9-(6-amino-9H-purin-9-yl)-5-hydroxy-8-methyl-, 1-methylethyl ester, 5-oxide, (8R)-
• Tenofovir Disoproxil Related CoMpound E
• [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphinic acid
• [2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-(isopropoxycar...
• (Mixture of DiastereoMers)
• Tenofovir monoisoproxil
• (R)-1-((9-((R)-2-hydroxypropyl)-9H-purin-6-yl)amino)propan-2-ol
• Tenofovir disoproxil-1
• Mono-POC Tenofovir Q: What is the CAS Number of
• Mono ester Tenofovir
• Tenofovir impurity I
• Tenofovir Disoproxil Impurity A(IP)
• (8R)-9-(6-Amino-9H-purin-9-yl)-5-hydroxy-8-methyl-2,4,7-trioxa-5-phosphanonanoic acid 1-methylethyl ester 5-oxide
• tenofovirMonoester
• Tenofovir disoproxil Impurity T
• Mono-POC Tenofovir Q: What are the applications of
• Tenofovir impurity 1/Mono POC Tenofovir(Mixture of Diastereomers)/((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl isopropyl carbonate
• Mono poc-Tenofovir impurity
• Tenofovir Disoproxil Fumarate IP Impurity A
• Mono-POC Tenofovir (Mixture of Diastere)
• Mono-POC TenofovirQ: What is
• isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(4-chlorophenoxy)phosphoryl)-L-alaninate fumarate
• Tenofovir disoproxil Impurity C
• ({[1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)({[(propan-2-yloxy)carbonyl]oxy}methoxy)phosphini
• Tenofovir mono poc
• Tenofovir Disoproxil Fumarate impurity E
• Tenofovir Impurity C
• Tenofovir Disoproxil Related
• Tenofovir Isoproxil Monoester

Tenofovir Soproxil (((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl)oxy)methyl isopropyl carbonate)

CAS: 211364-69-1

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Fórmula: C₁₄H₂₂N₅O₇P

Forma y color: White Off-White Solid

Peso molecular: 403.12569

Ref: 45-1A04320

2,4,7-Trioxa-5-phosphanonanoic acid, 9-(6-amino-9H-purin-9-yl)-5-hydroxy-8-methyl-, 1-methylethyl ester, 5-oxide, (8R)-

CAS: 211364-69-1

Fórmula: C₁₄H₂₂N₅O₇P

Pureza: 98%

Forma y color: Solid

Peso molecular: 403.3275

Ref: IN-DA002LB3

Tenofovir Impurity 132

CAS: 211364-69-1

Fórmula: C₁₄H₂₂N₅O₇P

Forma y color: White To Off-White Solid

Peso molecular: 403.33

Ref: 4Z-T-0212

Tenofovir Disoproxil Fumarate IP Impurity D

CAS: 211364-69-1

Fórmula: C₁₄H₂₂N₅O₇P

Peso molecular: 403.33

Ref: ST-EA-CP-T5001

Mono-POC Tenofovir

CAS: 211364-69-1

Stability Hygroscopic
Applications An impurity of Tenofovir Disoproxil (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. It is used as an anti-HIV agent and an antiviral.
References Gan, L., et al.: Drug Metab. Dispos., 24, 344 (1996), Annaert, P., et al.: Pharm. Res., 14, 492 (1997), Naesens, L., et al.: Antimicrob. Agents Chemother., 42, 1568 (1998), Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Fórmula: C₁₄H₂₂N₅O₇P

Forma y color: White To Light Beige

Peso molecular: 403.33

Ref: TR-M567000

Tenofovir isoproxil monoester

CAS: 211364-69-1

Tenofovir isoproxil monoester is a prodrug of Tenofovir, which is an antiviral drug. Tenofovir prevents the growth of HIV by interfering with the synthesis of viral DNA. The process development stage involves converting Tenofovir to its disoproxil monoester form, which has been shown to have greater antiviral activity than Tenofovir alone. This conversion process involves condensing one molecule of fumarate with two molecules of tenofovir, forming tenofovir disoproxil fumarate (TFD). TFD can be converted back to Tenofovir using hydrolysis and hydrogenation. Impurities in TFD include isopropyl tenofovir and unidentified impurities that are not present in the parent drug, tenofovir. Tenofovir Disoproxil Fumarate was also shown to be more potent than TFD and is undergoing clinical trials for

Fórmula: C₁₄H₂₂N₅O₇P

Pureza: Min. 97 Area-%

Forma y color: White/Off-White Solid

Peso molecular: 403.33 g/mol

Ref: 3D-IT46734