CAS 2140-72-9

2'-O-Metilcitidina

Descripción:

2'-O-Metilcitidina es un nucleósido modificado que desempeña un papel significativo en varios procesos biológicos, particularmente en la biología del ARN. Se caracteriza por la presencia de un grupo metilo en la posición 2′ de la parte de azúcar ribosa de la citidina, lo que mejora la estabilidad de las moléculas de ARN e influye en sus interacciones con proteínas y otros ácidos nucleicos. Esta modificación se encuentra comúnmente en la estructura de ciertos tRNAs y rRNAs, contribuyendo a su integridad funcional y eficiencia. La presencia del grupo metilo también puede afectar las propiedades de apareamiento de bases y la conformación general del ARN, impactando procesos como la traducción y la regulación génica. 2'-O-Metilcitidina se utiliza a menudo en investigaciones y aplicaciones terapéuticas, incluyendo el desarrollo de fármacos y vacunas basados en ARN, debido a su capacidad para modular las respuestas inmunitarias y mejorar las propiedades farmacocinéticas de los oligonucleótidos. Su número CAS, 2140-72-9, es un identificador único que facilita la catalogación y el estudio de este compuesto en la literatura científica y bases de datos.

Fórmula: C₁₀H₁₅N₃O₅

InChI: InChI=1/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7+,8+,9-/m1/s1

Clave InChI: InChIKey=RFCQJGFZUQFYRF-ZOQUXTDFSA-N

SMILES: O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)C=C2

Sinónimos:

• Cytidine, 2′-O-methyl-
• O2′-Methylcytidine
• 2′-O-Methylcytidine
• 4-Amino-1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one
• 2'-O-Methylcytidineanhydrous
• 2''-(O-METHYL)-CYTIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM
• 2'-O-Methyl-D-cytidine

2'-O-Methylcytidine

CAS: 2140-72-9

Fórmula: C₁₀H₁₅N₃O₅

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 257.25

Ref: 3B-M2317

2'-O-Methylcytidine, 99%

CAS: 2140-72-9

2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 99%

Peso molecular: 257.24

Ref: 02-J65528

Cytidine, 2'-​O-​methyl-

CAS: 2140-72-9

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 257.2432

Ref: IN-DA00I44O

2''-O-Methylcytidine

CAS: 2140-72-9

Fórmula: C₁₀H₁₅N₃O₅

Peso molecular: 257.24

Ref: 7W-GE9294

2’-O-Methylcytidine

CAS: 2140-72-9

2’-O-Methylcytidine

Pureza: 98%

Peso molecular: 257.24g/mol

Ref: 54-OR1010238

2′-O-Methylcytidine

CAS: 2140-72-9

2′-O-Methylcytidine

Pureza: ≥98%

Peso molecular: 257.24g/mol

Ref: 54-BUP17963

2′-O-Methylcytidine

CAS: 2140-72-9

2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 99.72%

Forma y color: Solid

Peso molecular: 257.24

Ref: TM-T38237

2’-O-Methyl Cytidine

Producto controlado

CAS: 2140-72-9

Applications Cytidine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Fórmula: C₁₀H₁₅N₃O₅

Forma y color: White

Peso molecular: 257.24

Ref: TR-M294660

2'-O-Methyl-d3 Cytidine

Producto controlado

CAS: 2140-72-9

Applications 2’-O-Methyl-d3 Cytidine is an isotopic labeled cytidine(M294660) analog. 2’-O-Methyl Cytidine is used for the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
References Eldrup, A.B.

Fórmula: C₁₀H₁₂D₃N₃O₅

Forma y color: White To Off-White

Peso molecular: 260.26

Ref: TR-M294662

2'-O-Methylcytidine

CAS: 2140-72-9

2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon. The hydroxyl group makes it an effective inhibitor of viral replication, and it has been shown to be active against HIV-1 in cell culture. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways, and the metabolic response can be studied using proton nuclear magnetic resonance (NMR) spectroscopy and x-ray diffraction data. It has been found that 2'-O-Methylcytidine inhibits protein synthesis in cancer cells, and this may be due to its ability to bind to the response element on DNA.

Fórmula: C₁₀H₁₅N₃O₅

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 257.24 g/mol

Ref: 3D-NM06302

2′-O-Methylcytidine

CAS: 2140-72-9

Fórmula: C₁₀H₁₅N₃O₅

Pureza: 95%

Forma y color: Solid, Crystalline Powder

Peso molecular: 257.246

Ref: 10-F219012

2'-O-Methylcytidine

CAS: 2140-72-9

Cis-2'-O-methylcytidine is a modified nucleoside that has shown antiviral and anticancer activity. It is a monophosphate analog of cytidine with high antiviral activity against HIV, HSV-1, HSV-2, EBV, and CMV. Cis-2'-O-methylcytidine also inhibits tumor growth in mice by inhibiting the synthesis of DNA. Cis-2'-O-methylcytidine has been synthesized from ribonucleosides and deoxyribonucleosides to provide high purity and quality.

Fórmula: C₁₀H₁₅N₃O₅

Peso molecular: 257.24 g/mol

Ref: 3D-J-700064