CAS 2140-73-0

1-Metilinosina

Descripción:

1-Metilinosina es un derivado de nucleósido caracterizado por la presencia de un grupo metilo en la posición N1 de la base de purina, inosina. Es un compuesto que se encuentra de forma natural en varios sistemas biológicos, particularmente en el ARN. La estructura molecular de 1-Metilinosina consiste en un azúcar ribosa unido a la base de purina, lo que contribuye a su papel en los procesos celulares. Este compuesto está involucrado en la regulación de la expresión génica y puede influir en diversas vías metabólicas. Su patrón de metilación único puede afectar la estabilidad y función de las moléculas de ARN, impactando la síntesis de proteínas y la señalización celular. 1-Metilinosina también es de interés en la investigación relacionada con la epitranscriptómica, donde se estudian las modificaciones del ARN por su significado biológico. El número CAS 2140-73-0 identifica de manera única este compuesto en bases de datos químicas, facilitando su estudio y aplicación en varios campos científicos, incluyendo la bioquímica y la biología molecular.

Fórmula: C₁₁H₁₄N₄O₅

InChI: InChI=1S/C11H14N4O5/c1-14-3-13-9-6(10(14)19)12-4-15(9)11-8(18)7(17)5(2-16)20-11/h3-5,7-8,11,16-18H,2H2,1H3/t5-,7-,8-,11-/m1/s1

Clave InChI: InChIKey=WJNGQIYEQLPJMN-IOSLPCCCSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N(C)C=N3)O[C@H](CO)[C@H]1O

Sinónimos:

• 2140-73-0
• Inosine, 1-methyl-
• N¹-Methylinosine
• 1-Methylinosine
• N1-Methylinosine

Inosine, 1-methyl

CAS: 2140-73-0

Fórmula: C₁₁H₁₄N₄O₅

Pureza: 97%

Forma y color: Solid

Peso molecular: 282.2527

Ref: IN-DA00C2V5

(2R,3R,4S,5R)-2-(6-Hydroxy-1-Methyl-1H-Purin-9(2H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

CAS: 2140-73-0

(2R,3R,4S,5R)-2-(6-Hydroxy-1-Methyl-1H-Purin-9(2H)-Yl)-5-(Hydroxymethyl)Tetrahydrofuran-3,4-Diol

Pureza: 99%

Peso molecular: 282.25g/mol

Ref: 54-OR1023913

1-Methylinosine

CAS: 2140-73-0

1-Methylinosine

Pureza: ≥98%

Peso molecular: 282.25g/mol

Ref: 54-BUP10688

1-Methylinosine

CAS: 2140-73-0

Fórmula: C₁₁H₁₄N₄O₅

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 282.26

Ref: 3B-M3670

1-Methylinosine

CAS: 2140-73-0

1-Methylinosine (N1-Methylinosine) is a modified nucleotide found at position 37 in tRNA 3' to the anticodon of eukaryotic tRNA and has a role as a metabolite.

Fórmula: C₁₁H₁₄N₄O₅

Pureza: 99.7%

Forma y color: Solid

Peso molecular: 282.25

Ref: TM-T19083

1-Methyl-Inosine

Producto controlado

CAS: 2140-73-0

Applications 1-Methyl-Inosine is a modified nucleoside which is present in higher concentrations in the urinary excretion of patients afflicted with breast cancer. It acts a a biomarker for diagnosis of the disease.
References Frickenschmidt, A. et al.: Biomark., 13, 435 (2008); Studzinska, S. et al.: J. Chrom. B. Tech. Biomed. Life Sci., 887, 93 (2012);

Fórmula: C₁₁H₁₄N₄O₅

Forma y color: Neat

Peso molecular: 282.25

Ref: TR-M313600

N1-Methylinosine

Producto controlado

CAS: 2140-73-0

N1-Methylinosine is a purine derivative that can be used as an imaging agent for the detection of autoimmune disorders. It has been shown to form stable complexes with proteins and human serum proteins, which have been detected in urine samples. N1-Methylinosine has also been used in clinical studies to measure disease activity in patients with rheumatoid arthritis and chronic kidney disease. This drug is activated by catalysis to produce a fluorescent product that can be detected using nmr spectroscopy. N1-Methylinosine is able to bind to autoantibodies and activate markers of chronic inflammation, such as nuclear factor kappa B (NF-κB) and tumor necrosis factor alpha (TNFα).
N1-Methylinosine has also been shown to inhibit breast cancer cell growth and reduce the severity of chronic kidney disease.

Fórmula: C₁₁H₁₄N₄O₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 282.25 g/mol

Ref: 3D-FM163160

Inosine, 1-methyl

CAS: 2140-73-0

Pureza: 97%

Peso molecular: 282.256012

Ref: 10-F863466

1-Methyl-Inosine-d3

Producto controlado

CAS: 2140-73-0

Applications 1-Methyl-Inosine-d3 is the isotope labelled analog of 1-Methyl-Inosine (M313600); a modified nucleoside which is present in higher concentrations in the urinary excretion of patients afflicted with breast cancer. It acts as a biomarker for diagnosis of the disease.
References Frickenschmidt, A. et al.: Biomark., 13, 435 (2008); Studzinska, S. et al.: J. Chrom. B. Tech. Biomed. Life Sci., 887, 93 (2012)

Fórmula: C₁₁D₃H₁₁N₄O₅

Forma y color: Neat

Peso molecular: 285.271

Ref: TR-M313602