CAS 217082-60-5

(Pyr1)-Apelina-13 (humano, bovino)

Descripción:

(Pyr1)-Apelina-13 es un péptido que actúa como un ligando para el receptor de apelina, que está involucrado en varios procesos fisiológicos, incluyendo la regulación cardiovascular, la homeostasis de fluidos y el metabolismo energético. Esta sustancia es una forma modificada del péptido de apelina-13 que ocurre de forma natural, donde el primer residuo de prolina es sustituido por un anillo de pirrolidina, lo que mejora su estabilidad y bioactividad. El péptido se caracteriza por su tamaño relativamente pequeño, compuesto por 13 aminoácidos, y exhibe una alta afinidad por el receptor de apelina, lo que lo hace significativo en la investigación relacionada con la salud cardiovascular y los trastornos metabólicos. Su papel en la promoción de la vasodilatación y la influencia en la regulación del apetito ha despertado interés en aplicaciones terapéuticas. Además, se estudia (Pyr1)-Apelina-13 por sus posibles implicaciones en condiciones como la insuficiencia cardíaca y la obesidad. El número CAS 217082-60-5 identifica de manera única este compuesto, facilitando su reconocimiento en la literatura científica y bases de datos. En general, (Pyr1)-Apelina-13 representa una herramienta valiosa en la investigación biomédica, particularmente en la comprensión de la vía de señalización de la apelina.

Fórmula: C₆₉H₁₀₈N₂₂O₁₆S

Sinónimos:

• (Pyr1)apelin-13
• (pGlu1)apelin-13
• Pyr-apelin-13
• L-Phenylalanine,5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-
• Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH

(Pyr¹)-Apelin-13 (human, bovine, mouse, rat)

CAS: 217082-60-5

The pyroglutamyl form of apelin-13 exhibited a high activity with an EC₅₀ value of 0.30 nM. pERPRLSHKGPMPF is probably the final product of the post-translational modification of apelin and the biologically active endogenous ligand. (Pyr¹)-Apelin-13 has been identified as the predominant apelin isoform in the human heart. Pyr-Apelin-13 stimulates glucose utilization in normal and obese insulin-resistant mice. It could be required for the maintenance of insulin sensitivity.

Fórmula: C₆₉H₁₀₈N₂₂O₁₆S

Pureza: 97.7%

Forma y color: White Lyophilisate

Peso molecular: 1533.82

Ref: 01-4029110

(Pyr¹)-Apelin-13 (human, bovine, mouse, rat)

CAS: 217082-60-5

Bachem ID: 4104812.

Fórmula: C₆₉H₁₀₈N₂₂O₁₆S

Pureza: 98.2301%

Forma y color: White Powder

Peso molecular: 1533.82

Ref: 01-4104812

PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH

CAS: 217082-60-5

Fórmula: C₆₉H₁₀₈N₂₂O₁₆S

Pureza: 97%

Forma y color: Solid

Peso molecular: 1533.7986

Ref: IN-DA00BBQH

[Pyr1]-Apelin-13

CAS: 217082-60-5

[Pyr1]-Apelin-13

Pureza: ≥98%

Peso molecular: 1533.8g/mol

Ref: 54-BUP01859

[Pyr1]-Apelin-13

CAS: 217082-60-5

[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist.

Fórmula: C₆₉H₁₀₈N₂₂O₁₆S

Pureza: 99.71%

Forma y color: Solid

Peso molecular: 1533.8

Ref: TM-TP1260

[Pyr]-Apelin-13

CAS: 217082-60-5

[Pyr1]-Apelin-13 acts as a ligand for the apelin receptor (APJ) G protein-coupled receptor and is a substrate for angiotensin-converting enzyme 2. Apelin is a member of the adipokine hormone family from adipose tissue. Adipokines are involved in processes such as vascular homeostasis and angiogenesis.Apelin and the apelin receptor are widely distributed throughout the body. Apelin is associated with cardiovascular diseases, obesity, diabetes and cancer. Apelin is expressed in the spinal cord and the human brain. Immunohistochemistry shows that apelin-17 is significantly expressed in the human heart, brain, lungs and endothelial cells. Studies show myocardial infarction apelin mRNA expression is greater during human heart failure than in healthy tissue. Apelin protects against heart failure due to the pyroglutamic form of apelin, [Pyr1]-Apelin-13, which decreases infarct size of myocardial infarctions. Furthermore, rats with hypertension have reduced levels of apelin and APJ. [Pyr1]-Apelin-13 exhibits higher APJ agonist potency than Apelin-13. We also have the alternative available.

Fórmula: C₆₉H₁₀₈N₂₂O₁₆S

Forma y color: Powder

Peso molecular: 1,533.8 g/mol

Ref: 3D-CRB1000443

[Pyr1]-Apelin-13 (Human, Bovine)

CAS: 217082-60-5

Apelin-13 is a peptide that belongs to the class of activators. It has been shown to activate the ATP-sensitive potassium ion channels and inhibit the calcium ion channels in cells. Apelin-13 also binds to receptors on cells, which leads to activation of signaling pathways. The affinity for these receptors has been determined using an antibody. In addition, it has been shown that Apelin-13 interacts with other proteins and ligands in a variety of ways through protein interactions and receptor binding.

Fórmula: C₆₉H₁₀₈N₂₂O₁₆S

Pureza: Min. 95%

Peso molecular: 1,533.8 g/mol

Ref: 3D-PAP-4361-V

(Pyr 1)-Apelin-13

CAS: 217082-60-5

Endogenous ligand for apelin APJ receptor

Fórmula: C₆₉H₁₀₈N₂₂O₁₆S

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 1,533.8 g/mol

Ref: 3D-FP109298