CAS 21820-51-9

Fosfo-L-tirosina

Descripción:

Fosfo-L-tirosina es un derivado fosforilado del aminoácido tirosina, caracterizado por la adición de un grupo fosfato al grupo hidroxilo (-OH) de la cadena lateral de tirosina. Esta modificación juega un papel crucial en la señalización celular y la función de las proteínas, particularmente en el contexto de eventos de fosforilación que regulan varios procesos biológicos. Fosfo-L-tirosina a menudo está involucrado en vías de transducción de señales, influyendo en procesos como el crecimiento celular, la diferenciación y el metabolismo. El compuesto es típicamente soluble en agua y exhibe una naturaleza polar debido a la presencia del grupo fosfato, lo que mejora su reactividad e interacción con otras biomoléculas. Su presencia en proteínas puede alterar significativamente su actividad e interacciones, convirtiéndolo en un jugador clave en la regulación de funciones enzimáticas y respuestas celulares. Fosfo-L-tirosina se utiliza comúnmente en investigaciones bioquímicas, particularmente en estudios relacionados con la actividad de la tirosina quinasa y el papel de la fosforilación en los mecanismos celulares.

Fórmula: C₉H₁₂NO₆P

InChI: InChI=1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1

Clave InChI: InChIKey=DCWXELXMIBXGTH-QMMMGPOBSA-N

SMILES: O(P(=O)(O)O)C1=CC=C(C[C@@H](C(O)=O)N)C=C1

Sinónimos:

• (2S)-2-Amino-3-(4-phosphonooxyphenyl)propanoic acid
• <span class="text-smallcaps">L</span>-Phosphotyrosine
• <span class="text-smallcaps">L</span>-Tyrosine, O-phosphono-
• <span class="text-smallcaps">L</span>-Tyrosine, dihydrogen phosphate (ester)
• <span class="text-smallcaps">L</span>-Tyrosine-O-phosphate
• H-Tyr(PO3)-OH
• N-phosphonotyrosine
• O-Phospho-<span class="text-smallcaps">L</span>-tyrosine
• O-Phosphono-<span class="text-smallcaps">L</span>-tyrosine
• O-Phosphotyrosine
• O-phosphono-L-tyrosine
• Phospho-<span class="text-smallcaps">L</span>-tyrosine
• Phosphotyrosine
• Tyrosine O-phosphate
• Tyrosine, di-H phosphate
• Tyrosine, dihydrogen phosphate (ester), <span class="text-smallcaps">L</span>-
• Tyrosine, phosphate
• L-Tyrosine, dihydrogen phosphate (ester)
• Tyrosine, dihydrogen phosphate (ester), L-

O-Phospho-L-tyrosine

CAS: 21820-51-9

Fórmula: C₉H₁₂NO₆P

Pureza: >97.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 261.17

Ref: 3B-P0959

H-Tyr(PO₃H₂)-OH

CAS: 21820-51-9

L-Phosphotyrosine can be used in the detection and quantification of tyrosine phosphorylation in proteins and as starting material in the synthesis of fluorescent substrates for protein tyrosine phosphatase assays. Furthermore, it has been incorporated in cyclic hexapeptides for studying intramolecular quenching of tryptophan fluorescence. L-Phosphotyrosine inhibits cellular growth by activating protein tyrosine phosphatases (Mishra and Hamburger). The phosphorylated amino acid protects TP53 wild-type cells against ionizing radiation.

Fórmula: C₉H₁₂NO₆P

Pureza: > 99%

Forma y color: Whitish Powder

Peso molecular: 261.17

Ref: 01-4025464

O-PHOSPHO-L-TYROSINE

CAS: 21820-51-9

Fórmula: C₉H₁₂NO₆P

Pureza: 95%

Forma y color: Solid

Peso molecular: 261.1684

Ref: IN-DA003THO

O-Phospho-L-tyrosine

CAS: 21820-51-9

Fórmula: C₉H₁₂NO₆P

Pureza: ≥ 95.0%

Forma y color: White to off-white powder

Peso molecular: 261.17

Ref: 7W-GM6522

H-Tyr(H2PO3)-OH

CAS: 21820-51-9

H-Tyr(H2PO3)-OH

Pureza: 98%

Peso molecular: 261.17g/mol

Ref: 54-OR1007549

O-Phospho-L-tyrosine

CAS: 21820-51-9

Applications Useful in the study of tyrosine-phosphorylation, which has been linked with the malignant transformation of cells by some RNA tumour viruses.
References Sefton, B.M., et al.: Cell, 20, 807 (1980), Erikson, R., et al.: Perspect. Virol., 11, 93 (1981), Lee, E-S, et al.: J. Org. Chem., 59, 2086 (1994)

Fórmula: C₉H₁₂NO₆P

Forma y color: Neat

Peso molecular: 261.17

Ref: TR-P365000

O-Phospho-L-tyrosine

CAS: 21820-51-9

Fórmula: C₉H₁₂NO₆P

Pureza: 98%

Forma y color: Solid

Peso molecular: 261.17

Ref: 10-F493251

O-Phospho-L-tyrosine

CAS: 21820-51-9

O-Phospho-L-tyrosine is a phosphorylated form of L-tyrosine. It is used as an immunogen in the production of monoclonal antibodies. O-Phospho-L-tyrosine has also been shown to inhibit the enzyme indole alkaloids, which are responsible for the development of oral pathogens. The dephosphorylation of O-Phospho-L-tyrosine by tyrosine phosphatases leads to its conversion back to L-tyrosine. This compound can be detected by chromatographic analysis and is commonly used in analytical methods to identify natural compounds.

Fórmula: C₉H₁₂NO₆P

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 261.17 g/mol

Ref: 3D-FP27018