CAS 221877-54-9

Zotarolimus

Descripción:

Zotarolimus, con el número CAS 221877-54-9, es un compuesto macrólido sintético que pertenece a la clase de agentes inmunosupresores. Se utiliza principalmente en el campo médico como un recubrimiento de stent liberador de fármacos para prevenir la reestenosis en las arterias coronarias después de la angioplastia. Zotarolimus funciona inhibiendo la proliferación de células musculares lisas y modulando la respuesta inmune, lo que ayuda a reducir el riesgo de obstrucción arterial. El compuesto exhibe un mecanismo de acción similar al de sirolimus, dirigiéndose a la vía del objetivo mamífero de la rapamicina (mTOR), que es crucial para el crecimiento celular y el metabolismo. Zotarolimus se caracteriza por su naturaleza lipofílica, que mejora su capacidad para adherirse a las superficies de los stents y liberarse gradualmente con el tiempo. Su farmacocinética implica una vida media relativamente larga, lo que permite efectos terapéuticos sostenidos. Se han establecido perfiles de seguridad y eficacia a través de estudios clínicos, lo que lo convierte en una herramienta valiosa en la cardiología intervencionista. Sin embargo, como todos los medicamentos, puede tener efectos secundarios y contraindicaciones potenciales que deben considerarse en la práctica clínica.

Fórmula:C₅₂H₇₉N₅O₁₂

InChI:InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1

Clave InChI:InChIKey=CGTADGCBEXYWNE-JUKNQOCSSA-N

SMILES:O(C)[C@H]1[C@](CC[C@@H](C[C@@H](C)[C@]2(OC(=O)[C@]3(N(C(=O)C(=O)[C@]4(O)O[C@](C[C@H](OC)\C(\C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)\C(\C)=C\[C@@H](C)C(=O)C2)(CC[C@H]4C)[H])CCCC3)[H])[H])C1)(N5C=NN=N5)[H]

Sinónimos:

(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin
42-(1-Tetrazolyl)rapamycin
A 179578
Abt 578
Endeavor
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Resolute
Unii-H4gxr80ize
Zotarolimus
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ABT-578;A-179578;ABT578;A179578;ABT 578;A 179578
(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin Zotarolimus(ABT-578) A 179578 Resolute
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
ZotaroliMus(ABT-578)
Zotarolimus, &gt
ZotaroliMus, >90%
ZOTAROLIMUS USP/EP/BP
ZOTAROLIMUS Impurities
ZotaroliMus API
42-deoxy-42-(1H-tetrazol-1-yl)-(42S)-Rapamycin
CS-1162
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Unii-H4gxr80ize
Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
Ver más sinónimos

Pureza (%)

100

Encontrado 7 productos.

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Zotarolimus
CAS:
- 221877-54-9
Fórmula:C₅₂H₇₉N₅O₁₂
Pureza:95%
Forma y color:Solid
Peso molecular:966.2100
Ref: IN-DA00BF84
1mg
96,00€
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5mg
162,00€
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25mg
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Zotarolimus
CAS:
- 221877-54-9
Zotarolimus
Pureza:≥95%
Peso molecular:966.21g/mol
Ref: 54-BUP04934
1mg
53,00€
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5mg
113,00€
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10mg
186,00€
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Zotarolimus
CAS:
- 221877-54-9
Fórmula:C₅₂H₇₉N₅O₁₂
Forma y color:Off-White Solid
Peso molecular:966.23
Ref: 4Z-Z-141
5mg
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10mg
698,00€
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25mg
1.153,00€
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50mg
2.002,00€
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100mg
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Zotarolimus
CAS:
- 221877-54-9
Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).
Fórmula:C₅₂H₇₉N₅O₁₂
Pureza:95% - 98.01%
Forma y color:Solid
Peso molecular:966.21
Ref: TM-T6033
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Zotarolimus-d3
CAS:
- 221877-54-9
Fórmula:C₅₂H₇₆D₃N₅O₁₂
Peso molecular:969.23
Ref: 4Z-Z-142
5mg
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Zotarolimus
CAS:
- 221877-54-9
<p>Inhibitor of immunophilin FKBP12 and mTOR signalling with immunosuppressant activity. Zotarolimus inhibits proliferation of endothelial cells and smooth muscle cells and is employed in vascular interventional therapies.</p>
Fórmula:C₅₂H₇₉N₅O₁₂
Pureza:Min. 95%
Forma y color:White Powder
Peso molecular:966.21 g/mol
Ref: 3D-FZ28788
2mg
135,00€
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5mg
166,00€
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10mg
224,00€
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25mg
382,00€
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Zotarolimus-d3, >90% (contains d0)
Producto controladoPor favor, tenga en cuenta que se trata de un producto controlado en algunos países y debe tratarse de acuerdo con la normativa pertinente. Tenga en cuenta que esto puede conllevar gastos y documentación adicionales.
CAS:
- 221877-54-9
Fórmula:C₅₂D₃H₇₆N₅O₁₂
Forma y color:Neat
Peso molecular:969.229
Ref: TR-Z700802
2500µg
1.509,00€
IVA no incluido
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