CAS 221877-54-9: Zotarolimus

Descripción: Zotarolimus, con el número CAS 221877-54-9, es un compuesto macrólido sintético que pertenece a la clase de agentes inmunosupresores. Se utiliza principalmente en el campo médico como un recubrimiento de stent liberador de fármacos para prevenir la reestenosis en las arterias coronarias después de la angioplastia. Zotarolimus funciona inhibiendo la proliferación de células musculares lisas y modulando la respuesta inmune, lo que ayuda a reducir el riesgo de obstrucción arterial. El compuesto exhibe un mecanismo de acción similar al de sirolimus, dirigiéndose a la vía del objetivo mamífero de la rapamicina (mTOR), que es crucial para el crecimiento celular y el metabolismo. Zotarolimus se caracteriza por su naturaleza lipofílica, que mejora su capacidad para adherirse a las superficies de los stents y liberarse gradualmente con el tiempo. Su farmacocinética implica una vida media relativamente larga, lo que permite efectos terapéuticos sostenidos. Se han establecido perfiles de seguridad y eficacia a través de estudios clínicos, lo que lo convierte en una herramienta valiosa en la cardiología intervencionista. Sin embargo, como todos los medicamentos, puede tener efectos secundarios y contraindicaciones potenciales que deben considerarse en la práctica clínica.

Fórmula: C₅₂H₇₉N₅O₁₂

InChI: InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1

Clave InChI: InChIKey=CGTADGCBEXYWNE-JUKNQOCSSA-N

SMILES: O=C1OC(CC(=O)C(C=C(C)C(O)C(OC)C(=O)C(C)CC(C=CC=CC=C(C)C(OC)CC2OC(O)(C(=O)C(=O)N3CCCCC13)C(C)CC2)C)C)C(C)CC4CCC(N5N=NN=C5)C(OC)C4

Sinónimos:

• (42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin
• 42-(1-Tetrazolyl)rapamycin
• A 179578
• Abt 578
• Endeavor
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Resolute
• Unii-H4gxr80ize
• Zotarolimus
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize
• Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
• Unii-H4gxr80ize

ZOTAROLIMUS

CAS: 221877-54-9

• Fórmula: C₅₂H₇₉N₅O₁₂
• Pureza: 95%
• Forma y color: Solid
• Peso molecular: 966.21

Zotarolimus

CAS: 221877-54-9

• Pureza: ≥98%
• Peso molecular: 966.21g/mol

Zotarolimus

CAS: 221877-54-9

• Fórmula: C₅₂H₇₉N₅O₁₂
• Forma y color: Off-White Solid
• Peso molecular: 966.23

Zotarolimus

CAS: 221877-54-9

Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).

• Fórmula: C₅₂H₇₉N₅O₁₂
• Pureza: 95% - ≥98%
• Forma y color: Solid
• Peso molecular: 966.21

Zotarolimus-d3

CAS: 221877-54-9

• Fórmula: C₅₂H₇₆D₃N₅O₁₂
• Peso molecular: 969.23

Zotarolimus

CAS: 221877-54-9

Inhibitor of immunophilin FKBP12 and mTOR signalling with immunosuppressant activity. Zotarolimus inhibits proliferation of endothelial …

• Fórmula: C₅₂H₇₉N₅O₁₂
• Pureza: Min. 95%
• Forma y color: White Powder
• Peso molecular: 966.21 g/mol

Zotarolimus-d3, >90% (contains d0)

CAS: 221877-54-9

• Fórmula: C₅₂D₃H₇₆N₅O₁₂
• Forma y color: Neat
• Peso molecular: 969.229