CAS 2228052-37-5

A-1155905

CAS: 2228052-37-5

A-1155905 is an MCL-1 inhibitor with anticancer activity, demonstrating a half maximal inhibitory concentration (IC50) of 33.5 Nm and a dissociation constant (Ki) of 0.58 nM. This compound selectively binds to MCL-1 and possesses sufficient affinity to disrupt the MCL-1-Bim complex in live cells. The induction of death in MCL-1-dependent cell lines by A-1155905 is reliant on caspase proteins and occurs through apoptosis.

Fórmula: C₄₆H₅₁FN₆O₆

Forma y color: Solid

Peso molecular: 802.93

Ref: TM-T200051