CAS 2240-28-0

(11beta,16beta)-9-fluoro-11,17-dihidroxi-16-metil-3,20-dioxopregna-1,4-dien-21-il pentanoato

Descripción:

La sustancia química conocida como "(11beta,16beta)-9-fluoro-11,17-dihidroxi-16-metil-3,20-dioxopregna-1,4-dien-21-il pentanoato," con el número CAS 2240-28-0, es un corticosteroide sintético. Exhibe propiedades antiinflamatorias e inmunosupresoras, lo que la hace útil en diversas aplicaciones terapéuticas, particularmente en el tratamiento de condiciones como alergias, asma y trastornos autoinmunes. La estructura de este compuesto presenta un átomo de flúor, que mejora su potencia y estabilidad metabólica en comparación con otros corticosteroides. La presencia de grupos hidroxilo contribuye a su solubilidad y actividad biológica. Además, el grupo éster pentanoato puede influir en su farmacocinética, permitiendo potencialmente una acción prolongada en el cuerpo. Al igual que con muchos corticosteroides, es esencial monitorear los efectos secundarios, incluidos los posibles impactos en el metabolismo y la función inmunológica. En general, este compuesto ejemplifica las modificaciones estructurales que pueden mejorar la eficacia terapéutica de los medicamentos basados en esteroides.

Fórmula: C₂₇H₃₇FO₆

InChI: InChI=1/C27H37FO6/c1-5-6-7-23(32)34-15-22(31)27(33)16(2)12-20-19-9-8-17-13-18(29)10-11-24(17,3)26(19,28)21(30)14-25(20,27)4/h10-11,13,16,19-21,30,33H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1

Clave InChI: InChIKey=FEROCCAEIIKMJT-SUYDQAKGSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C(CC3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@H](C)[C@@]2(C(COC(CCCC)=O)=O)O)[H]

Sinónimos:

• (11β,16β)-9-Fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxopentyl)oxy]pregna-1,4-diene-3,20-dione
• Betamethasone 21-valerate
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-((1-oxopentyl)oxy)-, (11beta,16beta)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxopentyl)oxy]-, (11β,16β)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-16beta-methyl-21-((1-oxopentyl)oxy)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16β-methyl-, 21-valerate
• BETAMETHASONE VALERATE RELATED COMPOUND A (50 MG) (BETAMETHASONE 21-VALERATE) (AS)
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(1-oxopentyl)oxy-, (11.beta.,16.beta.)-
• BetaMethasone Valerate Related CoMpound A
• Betamethasone Valerate Impurity E
• Betamethasone Valerate EP Impurity E
• Betamethasone Valerate impurity 4/Betamethasone Valerate EP Impurity E/Betamethasone 21-Valerate
• Betamethasone Valerate EP Impurity E (Betamethasone 21-Valerate)
• Betamethasone 21-valerate CRS
• Betamethasone impurity E (PhEur)

Betamethasone Valerate EP Impurity E

CAS: 2240-28-0

Fórmula: C₂₇H₃₇FO₆

Peso molecular: 476.59

Ref: ST-EA-CP-B5005

BETAMETHASONE 21-VALERATE CRS

CAS: 2240-28-0

BETAMETHASONE 21-VALERATE CRS

Fórmula: C₂₇H₃₇FO₆

Peso molecular: 476.5775

Ref: 41-B1055000

Betamethasone 21-valerate

CAS: 2240-28-0

Betamethasone 21-valerate

Forma y color: White

Ref: 47-43

Betamethasone Valerate Related Compound A (9-Fluoro-11β,17-dihydroxy-16β-methyl-3,20-dioxopregna-1,4-diene-21-yl valerate)

CAS: 2240-28-0

Halogenated derivatives of adrenal cortical hormones

Fórmula: C₂₇H₃₇FO₆

Forma y color: White Fine Powder

Peso molecular: 476.58

Ref: 45-1069018

Betamethasone 21-valerate

CAS: 2240-28-0

Betamethasone 21-valerate

Pureza: ≥95%

Ref: 54-BI12237

Betamethasone Valerate EP Impurity E (Betamethasone Valerate USP Related Compound A, Betamethasone 21-Valerate)

CAS: 2240-28-0

Fórmula: C₂₇H₃₇FO₆

Forma y color: White To Off-White Solid

Peso molecular: 476.59

Ref: 4Z-B-065012

9-Fluoro-11β,17-dihydroxy-16β-methyl-3,20-dioxopregna-1,4-dien-21-yl Pentanoate (Betamethasone 21-Valerate)

Producto controlado

CAS: 2240-28-0

Fórmula: C₂₇H₃₇FO₆

Forma y color: Neat

Peso molecular: 476.58

Ref: 86-MM0203.01

Betamethasone 21-Valerate

CAS: 2240-28-0

Impurity Betamethasone Valerate EP Impurity E
Applications Betamethasone 21-Valerate (Betamethasone Valerate EP Impurity E) is an isomeric impurity of Betamethasone 17-Valerate (B327075), as an corticosteroid. Betamethasone 21-Valerate was generated in the stress study of the active drug Betamethasone 17-Valerate (B327075).
References Caron, J.C., et al.: J. Pharmaceut. Sci., 73, 1703 (1984); Stouch, T.R., et al.: J. Med. Chem., 29, 2125 (1986);

Fórmula: C₂₇H₃₇FO₆

Forma y color: White

Peso molecular: 476.58

Ref: TR-B327080

Betamethasone 21-valerate

CAS: 2240-28-0

Betamethasone 21-valerate is a corticosteroid ester with anti-inflammatory properties.

Fórmula: C₂₇H₃₇FO₆

Forma y color: Solid

Peso molecular: 476.58

Ref: TM-T200792

Betamethasone-d9 21-Valerate

Producto controlado

CAS: 2240-28-0

Fórmula: C₂₇D₉H₂₈FO₆

Forma y color: Neat

Peso molecular: 485.633

Ref: TR-B327082

Betamethasone valerate related compound A

Producto controlado

CAS: 2240-28-0

Betamethasone valerate related compound A is a corticosteroid compound that is used in the treatment of inflammation. It has anti-inflammatory and immunosuppressive properties, which are thought to be due to its inhibition of farnesyltransferase. Betamethasone valerate related compound A can be given as an intranasal solution or by injection. The drug substance is a mixture of betamethasone 17-valerate and betamethasone 17,21-dipropionate, which have different kinetic properties. The chemical stability of the drug substance is maintained by using a reaction mechanism involving chromatography.

Fórmula: C₂₇H₃₇FO₆

Pureza: Min. 95%

Peso molecular: 476.58 g/mol

Ref: 3D-FB63637