CAS 2304947-71-3

TH 5487

CAS: 2304947-71-3

Fórmula: C₁₉H₁₈BrIN₄O₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 541.1803

Ref: IN-DA01KL47

4-(4-Bromo-2-Oxo-2,3-Dihydro-1H-Benzo[d]Imidazol-1-Yl)-N-(4-Iodophenyl)Piperidine-1-Carboxamide

CAS: 2304947-71-3

4-(4-Bromo-2-Oxo-2,3-Dihydro-1H-Benzo[d]Imidazol-1-Yl)-N-(4-Iodophenyl)Piperidine-1-Carboxamide

Pureza: 98%

Peso molecular: 541.18g/mol

Ref: 54-OR1023008

TH5487

CAS: 2304947-71-3

TH5487

Pureza: ≥95%

Peso molecular: 541.18g/mol

Ref: 54-BUP09023

TH5487

CAS: 2304947-71-3

TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)

Fórmula: C₁₉H₁₈BrIN₄O₂

Pureza: 98.38% - 98.73%

Forma y color: Solid

Peso molecular: 541.18

Ref: TM-T8119

TH 5487

CAS: 2304947-71-3

Specific inhibitor of 8-oxoguanine glycosylase OGG1 with IC50 in submicromolar range. The compound inhibits binding of OGG1 to its substrate 8-oxoguanine, a guanine analog generated in the presence of reactive oxygen species (ROS). It was shown that TH5487 decreases inflammation level by inhibiting the base excision DNA repair in mice and altering the OGG1 chromatin dynamics. The compound also has implications in cancer biology since OGG1 inhibitors sensitise tumours to chemotherapy.

Fórmula: C₁₉BrH₁₈IN₄O₂

Pureza: Min. 95%

Forma y color: Solid

Peso molecular: 541.18 g/mol

Ref: 3D-BT168024