CAS 23327-57-3

(±)-Clorhidrato de nefopam

Descripción:

(±)-Clorhidrato de nefopam es un compuesto sintético reconocido principalmente por sus propiedades analgésicas. Se clasifica como un analgésico no opioide y se utiliza a menudo para manejar el dolor, particularmente en casos donde los opioides tradicionales pueden no ser adecuados. La sustancia exhibe un mecanismo de acción único, principalmente a través de la inhibición de la recaptación de neurotransmisores como la serotonina, la norepinefrina y la dopamina, lo que contribuye a sus efectos analgésicos. Químicamente, es una mezcla racémica, lo que significa que contiene partes iguales de dos enantiómeros, que pueden exhibir diferentes actividades farmacológicas. El clorhidrato de nefopam se administra típicamente en su forma de sal clorhidrato, mejorando su solubilidad y estabilidad. El compuesto es conocido por su relativamente baja incidencia de efectos secundarios en comparación con los opioides, lo que lo convierte en una alternativa valiosa en el manejo del dolor. Sin embargo, aún puede causar algunos efectos adversos, incluyendo náuseas y mareos. Al igual que con cualquier medicamento, su uso debe ser guiado por un profesional de la salud, considerando las necesidades individuales del paciente y las posibles interacciones con otros medicamentos.

Fórmula: C₁₇H₁₉NO·ClH

InChI: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

Clave InChI: InChIKey=CNNVSINJDJNHQK-UHFFFAOYSA-N

SMILES: CN1CC=2C(C(OCC1)C3=CC=CC=C3)=CC=CC2.Cl

Sinónimos:

• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride
• 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride (1:1)
• 3,4,5,6-Tetrahydro-5-Methyl-1-Phenyl-1H-2,5-Benzoxazocine Hydrochloride
• 3-Methyl-7-Phenyl-6-Oxa-3-Azabicyclo[6.4.0]Dodeca-8,10,12-Triene Hydrochloride
• 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocin-5-ium chloride
• Acupan
• Fenazoxine
• Fenazoxine hydrochloride
• Nefopam HCl
• R 738
• Nefopam hydrochloride

Nefopam Hydrochloride

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO·HCl

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 289.80

Ref: 3B-N1169

5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine hydrochloride

CAS: 23327-57-3

Pureza: 95.0%

Forma y color: Solid

Peso molecular: 289.79998779296875

Ref: 10-F241971

Nefopam Hydrochloride

CAS: 23327-57-3

Forma y color: Neat

Ref: 61-FOR1189.00

Nefopam Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 23327-57-3

Forma y color: Single Solution

Ref: 61-AMP1189.00-01

(±)-Nefopam (hydrochloride)

CAS: 23327-57-3

Fórmula: C₁₇H₂₀ClNO

Pureza: 98%

Forma y color: Solid

Peso molecular: 289.7998

Ref: IN-DA002MVZ

Nefopam hydrochloride

CAS: 23327-57-3

Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.

Fórmula: C₁₇H₂₀ClNO

Pureza: 99.32% - 99.85%

Forma y color: Solid

Peso molecular: 289.8

Ref: TM-T0470

Nefopam hydrochloride

CAS: 23327-57-3

Nefopam hydrochloride

Pureza: ≥98%

Peso molecular: 289.8g/mol

Ref: 54-BUP18744

Nefopam hydrochloride

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO·HCl

Pureza: ≥ 98.0%

Forma y color: White to off-white or beige powder

Peso molecular: 289.80

Ref: 7W-GP9613

Nefopam HCl

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO·HCl

Forma y color: White To Off-White Solid

Peso molecular: 253.35 36.46

Ref: 4Z-N-371

Nefopam Hydrochloride

CAS: 23327-57-3

Nefopam Hydrochloride

Pureza: 98%

Peso molecular: 289.8g/mol

Ref: 54-OR1029203

Nefopam-d4 HCl

CAS: 23327-57-3

Fórmula: C₁₇H₁₅D₄NO·HCl

Forma y color: White To Off-White Solid

Peso molecular: 257.37 36.46

Ref: 4Z-N-376

Nefopam Hydrochloride

Producto controlado

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO·ClH

Forma y color: Neat

Peso molecular: 289.80

Ref: 86-MM1189.00

Nefopam Hydrochloride

Producto controlado

CAS: 23327-57-3

Applications A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bassett, et al.: Br. J. Pharmacol., 37, 69 (1969), Klohs, et al.: Arzneim.-Forsch., 22, 132 (1972), Hell, et al.: Drugs, 19, 249 (1980),

Fórmula: C₁₇H₁₉NO·ClH

Forma y color: White To Off-White

Peso molecular: 289.8

Ref: TR-N389400

Nefopam HCl - Bio-X ™

CAS: 23327-57-3

Nefopam is a non-narcotic analgesic drug that has been used in the treatment of chronic pain. It belongs to the class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Nefopam is also a nasal drug that relieves pain by blocking neurokinin 1 receptor, which reduces the production of prostaglandins. Nefopam acts in the brain and spinal cord to relieve pain through different mechanisms such as antinociceptive effects from triple monoamine reuptake inhibition, and antihyperalgesic activity through modulation of glutamatergic transmission.

Fórmula: C₁₇H₁₉NO·HCl

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 289.8 g/mol

Ref: 3D-FN65100

Nefopam hydrochloride

CAS: 23327-57-3

3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride (THPP) is a drug that is used as an analgesic and anti-inflammatory agent. THPP interacts with nonsteroidal anti-inflammatory drugs (NSAIDs) to cause neuronal death. It has been shown to inhibit the plate test for prostaglandin synthesis in human erythrocytes. The disulfide bond between cysteine residues on the protein molecule is susceptible to oxidative cleavage by reactive oxygen species from reactive oxygen species such as hydrogen peroxide and lipid peroxidation products. This can lead to the formation of a thiolate ion and a sulfenic acid intermediate. THPP is also known to produce chronic oral toxicity in rats at doses of 837 mg/kg/day for two months. A chemiluminescence method was used to measure the reaction

Fórmula: C₁₇H₂₀ClNO

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 289.8 g/mol

Ref: 3D-FN26174

N-Hydroxymethyl Nefopam N-Oxide

CAS: 23327-57-3

Fórmula: C₁₇H₁₉NO₃

Forma y color: White To Off-White Solid

Peso molecular: 285.35

Ref: 4Z-N-3710