CAS 23583-48-4

8-Bromo-AMPc

Descripción:

8-Bromo-AMPc, con el número CAS 23583-48-4, es un derivado sintético del monofosfato de adenosina cíclico (cAMP), un segundo mensajero crucial en varios procesos biológicos. Este compuesto se caracteriza por la presencia de un átomo de bromo en la posición 8 del anillo de adenina, lo que mejora su estabilidad y altera su actividad biológica en comparación con el cAMP natural. 8-Bromo-AMPc se utiliza a menudo en investigaciones bioquímicas para estudiar las vías de transducción de señales, particularmente aquellas que involucran la proteína quinasa A (PKA), ya que puede imitar los efectos del cAMP mientras es resistente a la degradación por fosfodiesterasas. El compuesto es típicamente soluble en agua y solventes orgánicos, lo que lo hace versátil para aplicaciones de laboratorio. Su capacidad para activar PKA e influir en las respuestas celulares lo convierte en una herramienta valiosa en farmacología y biología celular. Sin embargo, al igual que muchas sustancias químicas, debe manejarse con cuidado, siguiendo los protocolos de seguridad apropiados debido a sus posibles efectos biológicos.

Fórmula: C₁₀H₁₁BrN₅O₆P

InChI: InChI=1/C10H11BrN5O6P/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14)/t3-,5-,6-,9-/m1/s1

Clave InChI: InChIKey=DVKQVRZMKBDMDH-UUOKFMHZSA-N

SMILES: BrC=1N(C=2C(N1)=C(N)N=CN2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(O)O4)[H])[H]

Sinónimos:

• (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
• 23583-48-4
• 3',5'-(Hidrogenofosfato) Ciclico De 8-Bromoadenosina
• 3',5'-(Hydrogenophosphate) Cyclique De 8-Bromoadenosine
• 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.
• 6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
• 8-Bromadenosin-cyclisch-3',5'-(hydrogenphosphat)
• 8-Bromo-cAMP
• 8-Bromo-cyclic 3',5'-AMP
• 8-Bromo-cyclic 3′,5′-AMP
• 8-Bromoadenosine Cyclic 3',5'-(Hydrogen Phosphate)
• 8-Bromoadenosine cyclic 3',5'-monophosphate
• 8-Bromoadenosine cyclic 3',5'-phosphate
• 8-Bromoadenosine cyclic 3′,5′-monophosphate
• 8-Bromoadenosine cyclic 3′,5′-phosphate
• 8-Bromoadenosine-cAMP
• Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate)
• Adenosine, 8-bromo-, cyclic 3′,5′-(hydrogen phosphate)
• Cyclic 8-bromoadenosine 3',5'-monophosphate
• Cyclic 8-bromoadenosine 3′,5′-monophosphate
• Nsc 171719
• 8-Bromo Cyclic Adenosine Monophosphate
• 8-BROMOADENOSINE-3-5-CYCLICMONOPHOSPHATE FREE ACID
• 8-Bromoadenosine 3',5'-monophosphate
• 8-Br-A-3:5-MP
• 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE USP/EP/BP
• -CyclicMonophosphate
• 8-BR-CAMP
• 8-BROMOADENOSINE 3' 5'-CYCLIC
• 8-bromo-3',5'-cyclic AMP
• 8-BR-CAMP,98+%
• B-cAMP
• 8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE
• 8-Bromoadenosine 3',5'-phosphoric acid
• 8-Bromoadenosine-3'',-5''-cyclic monophosphoric acid
• 8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE
• 8-Bromocyclic AMP
• 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE
• Cyclic amp, 8-bromo
• 8-BROMOADENOSINE-3',5'-CYCLOPHOSPHORIC ACID

8-Bromoadenosine-3',5'-cyclic monophosphate

CAS: 23583-48-4

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Fórmula: C₁₀H₁₁BrN₅O₆P

Peso molecular: 408.11

Ref: 02-J64469

8-Bromoadenosine cyclic 3',5'-monophosphate

CAS: 23583-48-4

Fórmula: C₁₀H₁₁BrN₅O₆P

Pureza: 98%

Forma y color: Solid

Peso molecular: 408.1020

Ref: IN-DA002NRS

8-Bromoadenosine 3'',5''-cyclic monophosphate

CAS: 23583-48-4

Fórmula: C₁₀H₁₁BrN₅O₆P

Peso molecular: 408.11

Ref: 7W-GN1084

8-Bromo-cAMP

CAS: 23583-48-4

8-Bromo-cAMP

Pureza: ≥95%

Peso molecular: 408.1g/mol

Ref: 54-OR1005158

8-Bromo-cAMP

CAS: 23583-48-4

8-Bromo-cAMP is a cell-permeable cAMP analogue and activator of CAMP-dependent protein kinase A that induces cell death and reduces proliferation.

Fórmula: C₁₀H₁₁BrN₅O₆P

Pureza: 97.30%

Forma y color: Solid

Peso molecular: 408.1

Ref: TM-T35424

8-Bromoadenosine 3',5'-cyclic monophosphate

CAS: 23583-48-4

8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cyclic nucleotide that is involved in the regulation of energy metabolism. It is a pharmacological agent that regulates the intracellular levels of cAMP and plays an important role in regulating cell proliferation, differentiation, and survival. 8-Br-cAMP binds to specific protein kinases and alters their activity. It also inhibits the enzymatic activity of DNA polymerase II. 8-Br-cAMP has been shown to inhibit tumor growth in mice with bone cancer. The mechanism by which this drug exerts its antitumor effect appears to be related to increased expression of basic proteins and decreased expression of phosphatase 2A, leading to increased activation of protein kinase A. 8-Br-cAMP also causes cellular accumulation of Ca2+ ions by stimulating an increase in the activity of phospholipase C, which hydrolyzes phosphat

Fórmula: C₁₀H₁₁BrN₅O₆P

Pureza: Min. 98 Area-%

Forma y color: Beige Powder

Peso molecular: 408.11 g/mol

Ref: 3D-NB07972

8-Bromo-cAMP

CAS: 23583-48-4

Pureza: 98%

Peso molecular: 406.96

Ref: 10-F554595