CAS 23651-95-8

Droxidopa

Descripción:

Droxidopa, con el número CAS 23651-95-8, es un análogo sintético del aminoácido de la norepinefrina, utilizado principalmente como medicamento para tratar la hipotensión ortostática neurogénica. Funciona como un profármaco, convirtiéndose en norepinefrina en el cuerpo, lo que ayuda a aumentar la presión arterial y mejorar el flujo sanguíneo. La fórmula química de Droxidopa es C9H11NO4, y tiene un peso molecular de aproximadamente 197.19 g/mol. Este compuesto se caracteriza por su capacidad para cruzar la barrera hematoencefálica, lo que lo hace efectivo en el tratamiento de condiciones asociadas con baja presión arterial debido a disfunción autonómica. Droxidopa se administra típicamente por vía oral y es conocido por su perfil de seguridad relativamente favorable, aunque puede causar efectos secundarios como dolor de cabeza, náuseas e hipertensión. Su farmacocinética implica una rápida absorción y metabolismo, con concentraciones plasmáticas máximas que ocurren dentro de unas pocas horas después de la administración. En general, Droxidopa representa una opción terapéutica significativa para los pacientes que sufren de formas específicas de hipotensión ortostática.

Fórmula: C₉H₁₁NO₅

InChI: InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1

Clave InChI: InChIKey=QXWYKJLNLSIPIN-JGVFFNPUSA-N

SMILES: [C@@H]([C@@H](C(O)=O)N)(O)C1=CC(O)=C(O)C=C1

Sinónimos:

• (-)-threo-3,4-Dihydroxyphenylserine
• (2S,3R)-3-(3,4-Dihydroxyphenyl)-2-amino-3-hydroxypropanoic acid
• (2S,3S)-2-ammonio-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate
• (betaS)-beta,3-dihydroxy-D-tyrosine
• (βR)-β,3-Dihydroxy-<span class="text-smallcaps">L</span>-tyrosine
• <span class="text-smallcaps">L</span>-DOPS
• <span class="text-smallcaps">L</span>-Threodops
• <span class="text-smallcaps">L</span>-Tyrosine, β,3-dihydroxy-, (βR)-
• <span class="text-smallcaps">L</span>-Tyrosine, β,3-dihydroxy-, threo-
• <span class="text-smallcaps">L</span>-threo-3,4-Dihydroxyphenylserine
• <span class="text-smallcaps">L</span>-threo-3-(3,4-Dihydroxyphenyl)serine
• <span class="text-smallcaps">L</span>-threo-DOPS
• <span class="text-smallcaps">L</span>-threo-β-(3,4-Dihydroxyphenyl)serine
• Northera
• Serine, 3-(3,4-dihydroxyphenyl)-
• Serine, 3-(3,4-dihydroxyphenyl)-, <span class="text-smallcaps">L</span>-threo-
• Sm 5688
• Tyrosine, Beta,3-Dihydroxy-
• beta,3-Dihydroxytyrosine
• threo-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid
• threo-3-(3,4-Dihydroxyphenyl)-<span class="text-smallcaps">L</span>-serine
• threo-Dopaserine
• Serine, 3-(3,4-dihydroxyphenyl)-, L-threo-
• L-Tyrosine, β,3-dihydroxy-, (βR)-
• (βR)-β,3-Dihydroxy-L-tyrosine
• L-threo-3,4-Dihydroxyphenylserine

Droxidopa

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 213.19

Ref: 3B-D4235

Droxidopa

CAS: 23651-95-8

Aromatic amino-alcohol-phenols, aromatic amino-acid-phenols and other aromatic amino compounds with oxygen function

Fórmula: C₉H₁₁NO₅

Forma y color: White Pale Yellow Powder

Peso molecular: 213.06372

Ref: 45-1229600

L-Tyrosine, β,3-dihydroxy-, (βR)-

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 213.1873

Ref: IN-DA002O25

Droxidopa

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Forma y color: Off-White Solid

Peso molecular: 213.19

Ref: 4Z-D-155003

Droxidopa (L-threo-3-(3,4-Dihydroxyphenyl)serine)

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Peso molecular: 213.19

Ref: 7W-GP7171

Droxidopa

CAS: 23651-95-8

Forma y color: Neat

Ref: 86-MM3786.00

Droxidopa

CAS: 23651-95-8

Droxidopa (L-DOPS), an oral prodrug, treats symptomatic orthostatic hypotension from neurogenic autonomic failure.

Fórmula: C₉H₁₁NO₅

Pureza: 97.27% - 99.88%

Forma y color: Solid

Peso molecular: 213.19

Ref: TM-T2547

L-threo-Droxidopa

Producto controlado

CAS: 23651-95-8

Fórmula: C₉H₁₁NO₅

Forma y color: Neat

Peso molecular: 213.19

Ref: TR-D689960

Droxidopa

CAS: 23651-95-8

Pureza: 98%

Peso molecular: 213.1889954

Ref: 10-F787591

L-threo-Droxidopa-13C6

Producto controlado

CAS: 23651-95-8

Fórmula: C₃C₆H₁₁NO₅

Forma y color: Neat

Peso molecular: 216.119

Ref: TR-D689963

L-threo-droxidopa

CAS: 23651-95-8

L-threo-droxidopa is a prodrug that is hydrolyzed in the liver to L-3,4-dihydroxyphenylalanine (L-DOPA) and then metabolized by dopamine β-hydroxylase to form dopamine. This drug has been shown to be effective for the treatment of Parkinson's disease. The long-term efficacy of this drug is unknown, but it has been shown to be safe and well tolerated for up to six months. L-threo-droxidopa has also been shown to be effective in lowering systolic blood pressure in patients with mild hypertension. The side effects of this drug include symptoms such as nausea, vomiting, dizziness, headache, and insomnia. However, these side effects are often transient and do not require discontinuation of treatment with this medication. There are no known interactions between L-threo-droxidopa and other drugs or foods. Pharmacological

Fórmula: C₉H₁₁NO₅

Pureza: Min. 95%

Forma y color: Off-White To Light (Or Pale) Beige Solid

Peso molecular: 213.19 g/mol

Ref: 3D-FT28252