CAS 2412688-16-3

INDEX NAME NOT YET ASSIGNED

Fórmula: C₃₁H₄₀FN₃O₄

Sinónimos:

• MORF-627
• 1-Pyrrolidineacetic acid, α-[5-fluoro-2-(6S)-5-oxaspiro[2.5]oct-6-ylphenyl]-3-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butoxy]-, (αS,3R)-
• S)-2-(5-Fluoro-2-((S)-5-oxaspiro

MORF-627

CAS: 2412688-16-3

MORF-627 is an orally active selective inhibitor of integrin αvβ6 (integrinαvβ6), with an IC50 of 9.2 nM as measured in a human serum ligand binding assay. It effectively inhibits αvβ6-mediated activation of TGF-β1 with an IC50 of 2.63 nM and suppresses SMAD2/3 phosphorylation, showing an IC50 of 8.3 nM. Additionally, MORF-627 ameliorates bleomycin-induced pulmonary fibrosis in mice.

Fórmula: C₃₁H₄₀FN₃O₄

Forma y color: Solid

Peso molecular: 537.67

Ref: TM-T203397