CAS 2457-80-9

5′-(Metiltio)adenosina

Descripción:

5′-(Metiltio)adenosina, también conocido como MTA, es un compuesto que ocurre de forma natural y desempeña un papel significativo en varios procesos biológicos. Es un derivado de adenosina, donde un grupo metiltio está unido a la posición 5' del azúcar ribosa. El MTA se caracteriza por su participación en la señalización celular y el metabolismo, particularmente en el contexto del metabolismo de purinas y como un posible modulador de funciones celulares. Exhibe propiedades como ser un sustrato para varias enzimas y tener implicaciones en la regulación de respuestas inmunitarias e inflamación. El MTA también es conocido por su papel en la síntesis de poliaminas, que son esenciales para el crecimiento y diferenciación celular. En términos de solubilidad, generalmente es soluble en agua y solventes polares, lo que lo hace accesible para diversas aplicaciones bioquímicas. Su número CAS, 2457-80-9, se utiliza para la identificación en bases de datos químicas y contextos regulatorios. En general, 5′-(Metiltio)adenosina es un compuesto de interés tanto en la investigación bioquímica como en aplicaciones terapéuticas potenciales.

Fórmula: C₁₁H₁₅N₅O₃S

InChI: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

Clave InChI: InChIKey=WUUGFSXJNOTRMR-IOSLPCCCSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CSC)[C@H]1O

Sinónimos:

• 5'-(Methylthio)adenosine
• 5'-Deoxy-5'-Methylthioadenosine
• 5'-Methylthioadenosine
• 5'-S-Methyl-5'-thioadenosine
• 5'-S-Methylthioadenosine
• 5′-(Methylthio)-5′-deoxyadenosine
• 5′-Deoxy(methylthio)adenosine
• 9-(5-S-methyl-5-thiopentofuranosyl)-9H-purin-6-amine
• Adenosine, 5'-S-methyl-5'-thio-
• Brn 0042420
• Methylthioadenosine
• Nsc 335422
• Vitamin L(sub 2)
• Vitamin L2
• Vitamin L₂
• β-<span class="text-smallcaps">D</span>-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-
• 4-26-00-03675 (Beilstein Handbook Reference)

Adenosine, 5'-S-methyl-5'-thio-

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: 95%

Forma y color: Solid

Peso molecular: 297.3335

Ref: IN-DA002OLP

5'-Methylthioadenosine

CAS: 2457-80-9

5'-Methylthioadenosine

Pureza: ≥98%

Peso molecular: 297.33g/mol

Ref: 54-BUP14383

5’-Methylthioadenosine

CAS: 2457-80-9

5’-Methylthioadenosine

Pureza: 98%

Peso molecular: 297.33g/mol

Ref: 54-OR1011792

5''-Deoxy-5''-(methylthio)adenosine

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Peso molecular: 297.33

Ref: 7W-GN7022

Adenosyl Methionine Impurity 1

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Forma y color: White To Off-White Solid

Peso molecular: 297.33

Ref: 4Z-A-106029

5'-Deoxy-5'-methylthioadenosine

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: >95.0%(T)(HPLC)

Forma y color: White to Light yellow to Light orange powder to crystal

Peso molecular: 297.33

Ref: 3B-M3801

5'-S-Methyl-5'-thioadenosine

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: 95%~99%

Forma y color: Powder

Peso molecular: 297.333

Ref: BP-SBP01153

5'-Methylthioadenosine

CAS: 2457-80-9

5'-Methylthioadenosine (Methylthioadenosine) is produced from S-adenosylmethionine and behaves as a powful inhibitory product.

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: 99.32% - 99.34%

Forma y color: Solid

Peso molecular: 297.33

Ref: TM-T8227

Adenosyl Methionine Impurity 1-13C5

CAS: 2457-80-9

Fórmula: C₆₁₃C₅H₁₅N₅O₃S

Peso molecular: 302.29

Ref: 4Z-A-106046

5'-Deoxy-5'-(methylthio)adenosine-d3

Producto controlado

CAS: 2457-80-9

Applications Labelled 5'-Deoxy-5'-(methylthio)adenosine (D242600). 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

Fórmula: C₁₁H₁₂D₃N₅O₃S

Forma y color: Neat

Peso molecular: 300.35

Ref: TR-D242602

5'-Deoxy-5'-(methylthio)adenosine-13C

Producto controlado

CAS: 2457-80-9

Applications A Labelled isotope of 5'-Deoxy-5'-(methylthio)adenosine (D242600) which is used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28)
References Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

Fórmula: CC₁₀H₁₅N₅O₃S

Forma y color: Neat

Peso molecular: 298.326

Ref: TR-D242604

5'-Deoxy-5'-(methylthio)adenosine

CAS: 2457-80-9

Applications 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

Fórmula: C₁₁H₁₅N₅O₃S

Forma y color: White To Off-White

Peso molecular: 297.33

Ref: TR-D242600

5'-Deoxy-5'-(methylthio)adenosine

CAS: 2457-80-9

5'-Deoxy-5'-(methylthio)adenosine is a nucleoside that has been shown to inhibit the growth of bowel cancer cells. 5'-Deoxy-5'-(methylthio)adenosine blocks the synthesis of DNA and RNA by inhibiting the action of enzymes involved in DNA metabolism. It also inhibits methionine synthase and phosphorylase, which are involved in protein synthesis. This compound has been shown to be effective in treating cancer tissues due to its ability to inhibit polymerase chain reactions and prevent the formation of cancerous cells.

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: (Hplc-Ms) Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 297.34 g/mol

Ref: 3D-ND07992

(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Pureza: 96%

Peso molecular: 297.33

Ref: 10-F230436

5'-Deoxy-5'-(methylthio)adenosine-15N5

Producto controlado

CAS: 2457-80-9

Fórmula: C₁₁H₁₅₁₅N₅O₃S

Forma y color: Neat

Peso molecular: 302.3

Ref: TR-D242603

5’-Deoxy-5’-(methylthio)adenosine

Producto controlado

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Forma y color: Neat

Peso molecular: 297.33

Ref: TR-D232740

5\'-Deoxy-5\'-(methylthio)adenosine

CAS: 2457-80-9

Fórmula: C₁₁H₁₅N₅O₃S

Peso molecular: 297.33

Ref: ST-EA-CP-A88010