CAS 247257-48-3

Fimasartán

Descripción:

Fimasartán es un antagonista del receptor de angiotensina II que se utiliza principalmente en el tratamiento de la hipertensión. Pertenece a la clase de medicamentos conocidos como sartanes, que actúan bloqueando la acción de la angiotensina II, una hormona que provoca la constricción de los vasos sanguíneos, reduciendo así la presión arterial. Fimasartán se caracteriza por su inhibición selectiva del receptor AT1, lo que contribuye a sus efectos antihipertensivos. La sustancia se administra típicamente por vía oral y tiene una vida media relativamente larga, lo que permite una dosificación una vez al día. En términos de su estructura química, Fimasartán presenta un marco molecular único que incluye un grupo bifenilo y un grupo ácido carboxílico, contribuyendo a sus propiedades farmacológicas. Generalmente es bien tolerado, con un perfil de efectos secundarios similar al de otros medicamentos de su clase, incluyendo mareos, fatiga y posibles efectos renales. Como con cualquier medicamento, es esencial usar Fimasartán bajo supervisión médica, considerando las posibles interacciones con otros fármacos y las condiciones de salud individuales del paciente.

Fórmula: C₂₇H₃₁N₇OS

InChI: InChI=1S/C27H31N7OS/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26/h7-10,12-15H,5-6,11,16-17H2,1-4H3,(H,29,30,31,32)

Clave InChI: InChIKey=AMEROGPZOLAFBN-UHFFFAOYSA-N

SMILES: C(C1=CC=C(C2=C(C=CC=C2)C=3NN=NN3)C=C1)N4C(CCCC)=NC(C)=C(CC(N(C)C)=S)C4=O

Sinónimos:

• 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-5-pyrimidineethanethioamide
• 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one
• 2-[2-Butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide
• 2-n-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one
• 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• Kanarb
• Fimasartan
• 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one USP/EP/BP
• 2-(2-butyl-4-Methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methoxy)pyriMidin-5-yl)-N,N-diMethylacetaMide-yl)-N,N-diMethylacetaMide
• 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrim
• BR-A-657
• 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide
• 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide
• KANARB; BR-A-657
• Fimasartan(BR-A-657)
• Unii-p58222188p
• 2-(2-butyl-4-methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[ 1,1'-biphenyl]-4-yl)methoxy)pyrimidin-5-yl)-N,N- dimethylacetamide
• FiMasartan USP/EP/BP

5-​Pyrimidineethanethio​amide, 2-​butyl-​1,​6-​dihydro-​N,​N,​4-​trimethyl-​6-​oxo-​1-​[[2'-​(2H-​tetrazol-​5-​yl)​[1,​1'-​biphenyl]​-​4-​yl]​methyl]​-

CAS: 247257-48-3

Fórmula: C₂₇H₃₁N₇OS

Pureza: 97%

Forma y color: Solid

Peso molecular: 501.6463

Ref: IN-DA002P8I

Fimasartan

CAS: 247257-48-3

Fimasartan

Pureza: ≥95%

Peso molecular: 501.65g/mol

Ref: 54-BUP06317

Fimasartan-d6

CAS: 247257-48-3

Fórmula: C₂₇H₂₅D₆N₇OS

Forma y color: White To Off-White Solid

Peso molecular: 507.69

Ref: 4Z-F-492

Fimasartan

CAS: 247257-48-3

Fórmula: C₂₇H₃₁N₇OS

Forma y color: White To Off-White Solid

Peso molecular: 501.65

Ref: 4Z-F-491

2-(1-((2'-(2H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2-Butyl-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-Yl)-N,N-Dimethylethanethioamide

CAS: 247257-48-3

2-(1-((2'-(2H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2-Butyl-4-Methyl-6-Oxo-1,6-Dihydropyrimidin-5-Yl)-N,N-Dimethylethanethioamide

Pureza: 99%

Peso molecular: 501.65g/mol

Ref: 54-OR1025664

Fimasartan

CAS: 247257-48-3

Fimasartan (BR-A-657), an ARB, treats hypertension and heart failure; safe with hydrochlorothiazide.

Fórmula: C₂₇H₃₁N₇OS

Pureza: 98.96%

Forma y color: Solid

Peso molecular: 501.65

Ref: TM-T2322

Fimasartan

CAS: 247257-48-3

Angiotensin II receptor antagonist

Fórmula: C₂₇H₃₁N₇OS

Pureza: Min. 95%

Forma y color: White To Yellow Solid

Peso molecular: 501.65 g/mol

Ref: 3D-FB75008

Fimasartan

Producto controlado

CAS: 247257-48-3

Applications Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.
References Lee, H., et al.: Drugs, 76, 1015 (2016)

Fórmula: C₂₇H₃₁N₇OS

Forma y color: Neat

Peso molecular: 501.65

Ref: TR-F342040