CAS 24730-10-7

Mesilato de dihidroergocristina

Descripción:

Mesilato de dihidroergocristina es un derivado semisintético de los alcaloides del cornezuelo, utilizado principalmente en aplicaciones farmacológicas. Se caracteriza por su capacidad para actuar como vasodilatador y se ha estudiado por sus posibles efectos neuroprotectores. El compuesto se presenta típicamente como una sal mesilato, que mejora su solubilidad y estabilidad en diversas formulaciones. Mesilato de dihidroergocristina exhibe una estructura compleja, con múltiples centros quirales, lo que contribuye a su actividad biológica. Se sabe que interactúa con receptores adrenérgicos y serotoninérgicos, influyendo en la liberación de neurotransmisores y el tono vascular. La sustancia se utiliza a menudo en el tratamiento de condiciones como trastornos vasculares periféricos y el deterioro cognitivo asociado con el envejecimiento. Los perfiles de seguridad y eficacia se establecen a través de estudios clínicos, aunque los efectos secundarios pueden incluir trastornos gastrointestinales y efectos cardiovasculares. Al igual que con muchos agentes farmacológicos, su uso debe ser monitoreado por profesionales de la salud para mitigar posibles reacciones adversas.

Fórmula: C₃₆H₄₅N₅O₈S

InChI: InChI=1/C35H41N5O5.CH4O3S/c1-20(2)34(37-31(41)23-16-25-24-11-7-12-26-30(24)22(18-36-26)17-27(25)38(3)19-23)33(43)40-28(15-21-9-5-4-6-10-21)32(42)39-14-8-13-29(39)35(40,44)45-34;1-5(2,3)4/h4-7,9-12,18,20,23,25,27-29,36,44H,8,13-17,19H2,1-3H3,(H,37,41);1H3,(H,2,3,4)/t23-,25-,27-,28+,29+,34-,35+;/m1./s1

Clave InChI: InChIKey=SPXACGZWWVIDGR-SPZWACKZSA-N

SMILES: O[C@@]12N([C@@H](CC3=CC=CC=C3)C(=O)N4[C@]1(CCC4)[H])C(=O)[C@@](NC(=O)[C@@H]5C[C@@]6(C=7C=8C(C[C@]6(N(C)C5)[H])=CNC8C=CC7)[H])(C(C)C)O2.S(C)(=O)(=O)O

Sinónimos:

• (5'Alpha,10Alpha)-5'-Benzyl-12'-Hydroxy-3',6',18-Trioxo-2'-(Propan-2-Yl)-9,10-Dihydroergotaman Methanesulfonate (1:1)
• 5'alpha-Benzyl-9,10alpha-dihydro-12'-hydroxy-2'-isopropylergotaman-3',6',18-trione monomethanesulphonate
• 9,10-Dihydroergocristine methanesulfonate
• Dihydroergocristine methanesulfonate
• Dihydroergocristinmesilat
• Dihydroergocristinmesilat [German]
• Ergocristine, 9,10-dihydro-, monomethanesulfonate (salt)
• Ergocristine, dihydro-, methanesulfonate
• Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'alpha,10alpha)-, monomethanesulfonate (salt)
• Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′-(phenylmethyl)-, (5′α,10α)-, methanesulfonate (1:1)
• Ergotaman-3′,6′,18-trione, 9,10-dihydro-12′-hydroxy-2′-(1-methylethyl)-5′-(phenylmethyl)-, (5′α,10α)-, monomethanesulfonate (salt)
• Ergotamane-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'-alpha,10-alpha)-, monomethanesulfonate (salt)
• GNF Pf 3462
• Unii-Ds7Cl18Uam
• Dihydroergocristine mesylate
• DIHYDROERGOCRISTINE METHANESULFONATE ERG OT ALKALOID, VASOC
• ergotamane-3’,6’,18-trione,9,10-dihydro-12’-hydroxy-2’-(1-methylethyl)-5’-(phe
• Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy- 2'-(1-methylethyl)-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt)
• (5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trionemesylate
• (5,10a)-9,10-Dihydro-12hydroxy-2(1-methylethyl)-5(phenylmethyl)-ergotamane-3618-trionemesylate]
• (5'alpha, 10alpha)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trione mesylate
• DIHYDROERGOCRYSTINE METHANESULFONATE SALT
• Dihydroergocristine mesilate (D1945000)
• (5'A,10A)-9,10-DIHYDRO-12'-HYDROXY-2'-(1-METHYLETHYL)-5'-(PHENYLMETHYL)-ERGOTAMAN-3',6',18-TRIONE MESYLATE
• Dihydroergocristine mesilate CRS
• 9,10-dihydro-ergocristinmonomethanesulfonate(salt)
• (5’-alpha,10-alpha)-nylmethyl)monomethanesulfonate(salt)
• dihydroergocristine methanesulfonate salt
• C13168
• Dihydroergotamine Mesilate Impurity E as Mesilate
• Dihydroergotamine Mesilate EP Impurity E as Mesilate

Dihydroergocristine methanesulfonate

CAS: 24730-10-7

5-HT receptor antagonist; partial agonist at adrenergic and dopaminergic receptors

Fórmula: C₃₆H₄₅N₅O₈S

Forma y color: White, Powder or crystals or crystalline powder

Peso molecular: 707.84

Ref: 02-J60638

DIHYDROERGOCRISTINE MESILATE CRS

CAS: 24730-10-7

DIHYDROERGOCRISTINE MESILATE CRS

Fórmula: C₃₆H₄₅N₅O₈S

Peso molecular: 707.8362

Ref: 41-D1945000

DIHYDROERGOCRISTINE MESILATE FOR ASSAY CRS

CAS: 24730-10-7

DIHYDROERGOCRISTINE MESILATE FOR ASSAY CRS

Ref: 41-Y0002323

Dihydroergocristine (mesylate)

CAS: 24730-10-7

Fórmula: C₃₆H₄₅N₅O₈S

Pureza: 99.86%

Forma y color: Solid

Peso molecular: 707.8362

Ref: IN-DA002P9C

Dihydroergocristine mesylate

CAS: 24730-10-7

Dihydroergocristine mesylate

Pureza: ≥98%

Peso molecular: 707.84g/mol

Ref: 54-BUP12047

Dihydroergocristine Mesilate

Producto controlado

CAS: 24730-10-7

Fórmula: C₃₅H₄₁N₅O₅·CH₄O₃S

Forma y color: Neat

Peso molecular: 707.84

Ref: 86-MM1812.00

Dihydroergocristine mesylate

CAS: 24730-10-7

DHEC mesylate is a vasodilator and α-adrenergic antagonist used for vascular dementia and as a geroprotector.

Fórmula: C₃₆H₄₅N₅O₈S

Pureza: 98.9% - 99.79%

Forma y color: Solid

Peso molecular: 707.84

Ref: TM-T11043

9,10-Dihydroergocristine Methanesulfonate

CAS: 24730-10-7

Fórmula: C₃₅H₄₁N₅O₅·CH₄O₃S

Peso molecular: 611.74 96.10

Ref: 4Z-E-088005

Dihydroergocristine Mesylate

CAS: 24730-10-7

Dihydroergocristine Mesylate

Peso molecular: 707.84g/mol

Ref: 54-BID1021

9,10-Dihydroergocristine Methanesulfonate

Producto controlado

CAS: 24730-10-7

Applications 9,10-Dihydroergocristine Methanesulfonate is an nontoxic and well tolerated drug that exerts agonistic and antagonistic activity on dopaminergic and adrenergic receptors. 9,10-Dihydroergocristine Methanesulfonate is known to exhibit protective properties to the brain against metabolic effects of ischemia by acting at a cellular level.
References Setti, M., et al.: Angiologia., 30, 98 (1978); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012); Benzi, G., et al.: Neurobiol. Aging., 9, 371 (1988);

Fórmula: C₃₅H₄₁N₅O₅·CH₄O₃S

Forma y color: Neat

Peso molecular: 707.84

Ref: TR-D446440

Dihydroergocristine mesylate

CAS: 24730-10-7

Dihydroergocristine is an anti-hypertensive drug that belongs to the class of pharmacological agents. It is used for the treatment of high blood pressure and has been shown to reduce the risk of stroke in patients with cerebrovascular disease. Dihydroergocristine has been found to inhibit the production of 5-hydroxytryptamine (5-HT) by binding to serotonin receptors in vitro, although its effects on human serum levels have not been determined. This drug also inhibits certain enzymes, such as energy metabolism and protein synthesis. Dihydroergocristine can be administered in a solution or as an injection, depending on the severity of symptoms.

Fórmula: C₃₆H₄₅N₅O₈S

Pureza: Min. 95%

Forma y color: Solid

Peso molecular: 707.84 g/mol

Ref: 3D-FD39334

Dihydroergocristine mesilate

CAS: 24730-10-7

Dihydroergocristine mesilate

Forma y color: White Solid

Ref: 47-120