CAS 25126-32-3

(27-tir(so(3)H))colecistoquinina-fragmento (26-33)-amida

Descripción:

La sustancia química conocida como "(27-tir(so(3)H))colecistoquinina-fragmento (26-33)-amida," con el número CAS 25126-32-3, es un fragmento peptídico derivado de la colecistoquinina (CCK), una hormona involucrada en la digestión y la saciedad. Este fragmento específico consiste en aminoácidos del 26 al 33 de la molécula de CCK, con una tirosina sulfatada en la posición 27, que es crucial para su actividad biológica. La presencia del grupo sulfato mejora la interacción del péptido con sus receptores, influyendo en varios procesos fisiológicos como la contracción de la vesícula biliar y la secreción de enzimas del páncreas. La estructura de este péptido incluye una secuencia de aminoácidos unidos por enlaces peptídicos, y exhibe propiedades típicas de los péptidos, como la solubilidad en agua y la estabilidad en condiciones fisiológicas. Su importancia biológica se subraya por su papel en el sistema gastrointestinal, lo que lo convierte en un tema de interés en estudios relacionados con la digestión, la regulación del apetito y las posibles aplicaciones terapéuticas en trastornos gastrointestinales.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

InChI: InChI=1/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1

SMILES: CSCC[C@@H](C(=NCC(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CCSC)C(=N[C@@H](CC(=O)O)C(=N[C@@H](Cc1ccccc1)C(=N)O)O)O)O)O)O)N=C([C@H](Cc1ccc(cc1)OS(=O)(=O)O)N=C([C@H](CC(=O)O)N)O)O

Sinónimos:

• (tyr(so3H)27)-cholecystokinin fragment*26-33 amid
• Sincalide
• Cholecystokinin Octapeptide
• Tyr(SO3H]27)Cholecystokinin fragment 26-33 Amide
• alpha-aspartyl-O-sulfotyrosylmethionylglycyltryptophylmethionyl-alpha-aspartylphenylalaninamide
• L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
• Sincalide(CCK-8)
• Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
• Caerulein, 1-de(5-oxo-L-proline)-2-de-L-glutamine-5-L-methionine-
• Cholecystokinin C-terminal octapeptide
• Cholecystokinin octapeptide (26-33 sulfated)
• Cholecystokinin-(26-33)-amide
• Cholecystokinin-8 (chicken)
• Cholecystokinin-8 (pig)
• Cholecystokinin-8 (Squalus acanthias)
• Cholecystokinin-8 (swine)
• Cholecystokinin-pancreozymin (swine intestine C-terminal octapeptide)
• Cholecystokinin-pancreozymin C-terminal octapeptide
• Human CCK-8
• L-Phenylalaninamide, L-α-aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
• Sincalid
• Sincalida

Cholecystokinin, CCK Octapeptide (26-33)

CAS: 25126-32-3

For cellular and molecular biology applications

Forma y color: White, Lyophilized Powder

Ref: 02-J66669

Cholecystokinin Octapeptide (sulfated)

CAS: 25126-32-3

CCK-8 exhibits various gastrointestinal effects as contraction of the gallbladder and stimulation of pancreatic secretion and gastrointestinal transit. In rats, CCK-8 facilitated the uptake of leptin from peripheral circulation to cerebrospinal fluid and its access to the hypothalamus.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: 98.42%

Forma y color: White Powder

Peso molecular: 1143.29

Ref: 01-4033010

3-10-Caerulein, 5-L-methionine-

CAS: 25126-32-3

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: 97%

Forma y color: Solid

Peso molecular: 1143.2690

Ref: IN-DA002QKR

Sincalide

CAS: 25126-32-3

Sincalide

Pureza: ≥98%

Peso molecular: 1143.27g/mol

Ref: 54-BUP02057

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide

CAS: 25126-32-3

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Peso molecular: 1143.27

Ref: 7W-GL1683

Sincalide

CAS: 25126-32-3

Sincalide

Forma y color: Powder

Peso molecular: 1,143.27g/mol

Ref: 54-BITH3042

Sincalide(CCK-8)

CAS: 25126-32-3

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: 95%~99%

Forma y color: White to Off-white Powder

Peso molecular: 1143.27

Ref: BP-BPPG057

Sincalide

CAS: 25126-32-3

Sincalide (CCK-8) is an injectable drug used to diagnose gallbladder and pancreas disorders; it's a cholecystokinin fragment.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: 98.32%

Forma y color: Solid

Peso molecular: 1143.27

Ref: TM-TP1197

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

CAS: 25126-32-3

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 is a versatile building block that can be used in research on complex compounds, fine chemicals, speciality chemicals and reagents. It is a high quality chemical that can be used as an intermediate or a scaffold. Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe NH2 is soluble in water and has a high degree of solubility in organic solvents. The compound is also stable under acidic conditions.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: Min. 98.0 Area-%

Peso molecular: 1,143.27 g/mol

Ref: 3D-W-107263

Sincalide

CAS: 25126-32-3

Sincalide is a cholecystokinin (CCK) analog that has been used as a pharmacological agent. It is an agonist for CCK-A receptors and inhibits the activity of protein kinase C. Sincalide also has been shown to suppress tumor growth in experimental models. A polymerase chain reaction analysis of cck-8, a rat CCK receptor gene, showed a high degree of homology with human CCK-A receptor genes. The physiological effects of sincalide are complex and depend on the presence or absence of other hormones such as insulin, glucagon, somatostatin, and leptin.

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 1,143.27 g/mol

Ref: 3D-FS41124

CCK-Octapeptide (26-33) (Sulfated Form)

CAS: 25126-32-3

CCK-Octapeptide (26-33) (Sulfated Form) is a peptide that has been shown to have a variety of biological effects. It has been found to enhance the activity of rifampicin against tuberculosis by increasing the activity of the kinase protein. CCK-Octapeptide (26-33) (Sulfated Form) also has natriuretic peptide-like activity, which means it can regulate blood pressure and fluid balance in the body. In addition, it has been shown to inhibit tumor growth and metastasis in animal models, possibly through its ability to modulate guanosine triphosphate-binding proteins. CCK-Octapeptide (26-33) (Sulfated Form) also exhibits trypsin inhibitory activity and thymidine uptake inhibition. Furthermore, it has been studied as a potential treatment for cancer and as an alternative to vasopressin or nesiritide in certain medical conditions where natriuretic peptides are used ther

Fórmula: C₄₉H₆₂N₁₀O₁₆S₃

Pureza: Min. 95%

Peso molecular: 1,143.3 g/mol

Ref: 3D-PCK-4100-V