
CAS 2607139-85-3
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ART899
CAS:ART899, a derivative of ART558, is a potent and specific conformational inhibitor of DNA polymerase θ (Polθ). It specifically inhibits the MMEJ activity of Polθ with an IC50 of 180 nM. Additionally, ART899 selectively enhances the radiosensitivity of tumor cells and possesses a strong independent antitumor effect on cancer cells.Fórmula:C19H16ClF4N3O4Forma y color:SolidPeso molecular:464.81
