CAS 26339-90-2

Escina Ib

Descripción:

Escina Ib, con el número CAS 26339-90-2, es un saponina triterpenoide derivada de las semillas del castaño de Indias (Aesculus hippocastanum). Se conoce por sus posibles propiedades terapéuticas, particularmente en el tratamiento de la insuficiencia venosa y condiciones relacionadas. Escina Ib exhibe actividades antiinflamatorias y antioxidantes, que contribuyen a su eficacia en la promoción de la salud vascular. El compuesto se caracteriza por su capacidad para mejorar la permeabilidad capilar y reducir el edema, lo que lo hace beneficioso en el manejo de la hinchazón y el malestar asociados con varios trastornos circulatorios. Además, los compuestos de escina, incluyendo Escina Ib, a menudo se estudian por su papel en la mejora de la microcirculación y en proporcionar efectos protectores contra el estrés oxidativo. Si bien se reconoce principalmente por sus aplicaciones medicinales, se continúa investigando su rango completo de actividades biológicas y usos potenciales en farmacología. Al igual que con muchos compuestos naturales, los efectos específicos y los mecanismos de acción pueden variar, lo que requiere una cuidadosa consideración en las aplicaciones clínicas.

Fórmula: C₅₅H₈₆O₂₄

InChI: InChI=1/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10-/t26-,27+,28+,29+,30+,31+,32-,33+,34+,35-,36-,37+,38+,39-,40-,41+,42-,43-,44-,47-,48-,49+,51-,52+,53+,54+,55-/m0/s1

Clave InChI: InChIKey=AXNVHPCVMSNXNP-OXPBSUTMSA-N

SMILES: C(O)[C@]12[C@](C=3[C@@](C)(C[C@H]1O)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)([C@](CO)(C)[C@@H](O[C@H]6[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](C(O)=O)O6)CC5)[H])[H])(CC(C)(C)[C@@H](OC(/C(=C\C)/C)=O)[C@@H]2OC(C)=O)[H]

Sinónimos:

• (3β,16α,21β,22α)-22-(acetyloxy)-16,24,28-trihydroxy-21-{[(2Z)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-β-D-glucopyranosiduronic acid
• (3β,4β,16α,21β,22α)-22-(Acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-β-<smallcap>D</span>-glucopyranosiduronic acid
• Aescin B
• Olean-12-ene-16α,21β,22α,24,28-pentol, 3β-[(O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-β-<smallcap>D</span>-glucopyranuronosyl)oxy]-, 22-acetate 21-((Z)-2-methylcrotonate)
• Oleanane, β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid deriv.
• beta-D-Glucopyranosiduronic acid, (3beta,16alpha,21beta(Z),22alpha)-22-(acetyloxy)-16,24,28-trihydroxy-21-((2-methyl-1-oxo-2-butenyl)oxy)olean-12-en-3-yl O-beta-D-glucopyranosyl-(1.2)-O-(beta-D-glucopyranosyl-(1.4))-
• escin Ib
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→4)]-
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→4)]-
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranosiduronic acid, [3β,4β,16α,21β(Z),22α]-22-(acetyloxy)-16,23,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→4)]-
• Oleanane, β-D-glucopyranosiduronic acid deriv.
• β-D-Glucopyranosiduronic acid, [3β,4β,16α,21β(Z),22α]-22-(acetyloxy)-16,23,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
• β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
• Olean-12-ene-16α,21β,22α,24,28-pentol, 3β-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranuronosyl)oxy]-, 22-acetate 21-((Z)-2-methylcrotonate)
• β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
• Aescin IB
• Escin IB(Aescin IB)
• Escin Impurity 2（Escin Ib）
• 22α-(Acetyloxy)-16α,24,28-trihydroxy-21β-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]oleana-12-ene-3β-yl 4-O-[2-O-(β-D-gluco-hexopyranosyl)-β-D-gluco-hexopyranosyl]-β-D-gluco-hexopyranosiduronic acid
• 3-<2''-(β-D-glucopyranosido)-4'-(β-D-glucopyranosido)-β-D-glucuronopyranosido>-21-β-angeloyl-22-α-acetylprotoescigenin
• β-d-Glucopyranosiduronic acid, [3β,16α,21β(Z),22α]-22-(acetyloxy)-16,24,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-d-glucopyranosyl-(1→2)-O-[β-d-glucopyranosyl-(1→4)]-
• Aescin ib, 98%, from Aesculus wilsonii Rehder

Escin IB

CAS: 26339-90-2

Fórmula: C₅₅H₈₆O₂₄

Peso molecular: 1131.27

Ref: 7W-GY9075

Escin IB

CAS: 26339-90-2

Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes the release of PGs.

Fórmula: C₅₅H₈₆O₂₄

Pureza: 95%~99%

Peso molecular: 1131.27

Ref: BP-BP0557

Escin IB

CAS: 26339-90-2

Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to

Fórmula: C₅₅H₈₆O₂₄

Pureza: 99.09% - 99.81%

Forma y color: Solid

Peso molecular: 1131.26

Ref: TM-T5S1389

Escin IB

CAS: 26339-90-2

Fórmula: C₅₅H₈₆O₂₄

Peso molecular: 1131.27

Ref: 4Z-I-083004

Escin ib

CAS: 26339-90-2

Natural glycoside

Fórmula: C₅₅H₈₆O₂₄

Pureza: ≥ 85.0 % (HPLC)

Forma y color: Powder

Peso molecular: 1131.26

Ref: 5G-80446

Escin Ib

CAS: 26339-90-2

Escin Ib is a natural saponin glycoside, which is derived from the seeds of Aesculus hippocastanum, commonly known as horse chestnut. Its mode of action involves inhibiting the enzyme hyaluronidase, thereby reducing capillary permeability and effectively controlling edema and inflammation. Additionally, it acts by stabilizing lysosomal membranes, further contributing to its anti-inflammatory effects.

Pureza: Min. 95%

Ref: 3D-FE145234

Escin Impurity B

CAS: 26339-90-2

Fórmula: C₅₅H₈₆O₂₄

Peso molecular: 1131.27

Ref: ST-EA-CP-E104002

AESCIN IB(SH)

CAS: 26339-90-2

Fórmula: C₅₅H₈₆O₂₄

Pureza: 103%

Forma y color: Solid

Peso molecular: 1131.2569

Ref: IN-DA00BE5S