CAS 265121-04-8

Fosaprepitant dimeglumina

Descripción:

Fosaprepitant dimeglumina es un compuesto sintético utilizado principalmente como antiemético en la prevención de náuseas y vómitos asociados con la quimioterapia. Es un profármaco de aprepitant, que actúa como un antagonista selectivo del receptor de neuroquinina-1 (NK1), inhibiendo así la acción de la sustancia P, un neuropéptido involucrado en el reflejo del vómito. La sustancia se caracteriza por su alta solubilidad en agua debido a la presencia del moiety de dimeglumina, que mejora su biodisponibilidad. Fosaprepitant se administra típicamente por vía intravenosa y es conocido por su eficacia en combinación con otros agentes antieméticos. Su farmacocinética incluye una rápida conversión a aprepitant en el cuerpo, con una vida media relativamente larga, lo que permite efectos antieméticos sostenidos. Los efectos secundarios comunes pueden incluir fatiga, mareos y trastornos gastrointestinales. Como agente terapéutico, Fosaprepitant dimeglumina desempeña un papel crucial en la mejora de la calidad de vida de los pacientes que se someten a tratamiento contra el cáncer al gestionar eficazmente las náuseas y vómitos inducidos por la quimioterapia.

Fórmula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

InChI: InChI=1S/C23H22F7N4O6P.C7H17NO5/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38);4-13H,2-3H2,1H3/t12-,19+,20-;4-,5+,6+,7+/m10/s1

Clave InChI: InChIKey=UGJUJYSRBQWCEK-GGXTVIBHSA-N

SMILES: C(N1[C@H]([C@@H](O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)OCC1)C3=CC=C(F)C=C3)C4=NN(P(=O)(O)O)C(=O)N4.[C@H]([C@@H]([C@@H](CO)O)O)([C@H](CNC)O)O

Sinónimos:

• 1-Deoxy-1-(Methylamino)-D-Glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)-4-Morpholinyl]Methyl]-2,5-Dihydro-5-Oxo-1H-1,2,4-Triazol-1-Yl]Phosphonate
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1)
• <span class="text-smallcaps">D</span>-Glucitol, 1-deoxy-1-(methylamino)-, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt)
• D-Glucitol, 1-deoxy-1-(methylamino)-, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4- morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)phosphonate (2:1) (salt)
• Fosaprepitant di(N-methylglucamine)
• Fosaprepitant dimeglumine [USAN]
• Ivemend
• Mk-0517
• Phosphonic acid, (3-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:2)
• Phosphonic acid, [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-, compd. with 1-deoxy-1-(methylamino)-<span class="text-smallcaps">D</span>-glucitol (1:2)
• Unii-D35Fm8T64X
• Fosaprepitant dimeglumine
• Fosapitant Dimeglumine

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fórmula: C₃₇H₅₆F₇N₆O₁₆P

Pureza: 98%

Forma y color: Solid

Peso molecular: 1004.8337

Ref: IN-DA00BF3G

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fosaprepitant dimeglumine

Pureza: ≥95%

Peso molecular: 1004.83g/mol

Ref: 54-BUP10189

Fosaprepitant Dimeglumine

CAS: 265121-04-8

Fórmula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

Forma y color: White To Off-White Solid

Peso molecular: 614.41 2*195.22

Ref: 4Z-F-361

Fosaprepitant-d4 Dimeglumine

CAS: 265121-04-8

Fórmula: C₂₃H₁₈D₄F₇N₄O₆P·2C₇H₁₇NO₅

Forma y color: White To Off-White Solid

Peso molecular: 618.44 2*195.22

Ref: 4Z-F-364

Fosaprepitant Dimeglumine

CAS: 265121-04-8

Fórmula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

Pureza: >95.0%(HPLC)(qNMR)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 1,004.84

Ref: 3B-F1355

Fosaprepitant Impurity 10

CAS: 265121-04-8

Fórmula: C₂₃H₂₂F₇N₄O₇P

Forma y color: White To Off-White Solid

Peso molecular: 630.42

Ref: 4Z-F-3617

Fosaprepitant dimeglumine

CAS: 265121-04-8

Fosaprepitant dimeglumine (MK-0517) is a soluble prodrug of aprepitant, which prevents nausea by blocking NK1 receptors.

Fórmula: C₃₇H₅₆F₇N₆O₁₆P

Pureza: 98% - 99.03%

Forma y color: Solid

Peso molecular: 1004.83

Ref: TM-T1790

Fosaprepitant Dimeglumine

Producto controlado

CAS: 265121-04-8

Applications Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
References Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000), Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001), Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007), Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009),

Fórmula: C₂₃H₂₂F₇N₄O₆P·2C₇H₁₇NO₅

Forma y color: White To Off-White

Peso molecular: 1004.83

Ref: TR-F727305

Bis((2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol); (3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid

CAS: 265121-04-8

Pureza: 98.05%

Peso molecular: 1004.844

Ref: 10-F979755

1-Deoxy-1-(methylamino)-D-glucitol [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]m ethyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate

CAS: 265121-04-8

Fosaprepitant is a drug that belongs to the class of drugs used for chemotherapy. It is a prodrug that is converted in vivo to aprepitant, its active form. Fosaprepitant acts as an antagonist of the neurokinin-1 receptor (NK-1R) and inhibits the binding of substance P, which leads to an anti-inflammatory effect. Fosaprepitant has been shown to inhibit the production of substance P in animal models, leading to a reduction in inflammation. In clinical trials, fosaprepitant has been shown to be safe and well tolerated when used with other drugs such as cisplatin and docetaxel in patients with cancer.

Fórmula: C₂₃H₂₂F₇N₄O₆P•(C₇H₁₇NO₅)₂

Pureza: Min. 95%

Forma y color: White To Off-White Solid

Peso molecular: 1,004.83 g/mol

Ref: 3D-FD46503

Fosaprepitant-d4 Dimeglumine

Producto controlado

CAS: 265121-04-8

Applications Fosaprepitant-d4 Dimeglumine is a labeled analogue of Fosaprepitant Dimeglumine (F727305), a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
References Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000), Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001), Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007), Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009),

Fórmula: C₃₇H₅₂D₄F₇N₆O₁₆P

Forma y color: Neat

Peso molecular: 1008.86

Ref: TR-F727307

Fosaprepitant-13C,15N3 Dimeglumine

Producto controlado

CAS: 265121-04-8

Fórmula: C₃₆CH₅₆F₇N₃N₃O₁₆P

Forma y color: Neat

Peso molecular: 1008.82

Ref: TR-F727308