CAS 26833-87-4

Homoharringtonina

Descripción:

Homoharringtonina, con el número CAS 26833-87-4, es un alcaloide natural derivado de la especie de planta Cephalotaxus harringtonia. Se conoce principalmente por su papel como agente antineoplásico, particularmente en el tratamiento de ciertos tipos de leucemia, como la leucemia mieloide aguda (LMA). El compuesto funciona inhibiendo la síntesis de proteínas, lo que finalmente conduce a la supresión de la proliferación de células cancerosas. Homoharringtonina exhibe un mecanismo de acción único al dirigirse al proceso de iniciación de la traducción eucariota, lo que lo hace distinto de otros agentes quimioterapéuticos. Se administra típicamente por vía intravenosa y se ha estudiado por su eficacia en combinación con otros fármacos de quimioterapia. La sustancia se caracteriza por su compleja estructura molecular, que incluye múltiples centros quirales, contribuyendo a su actividad biológica. Si bien muestra promesas en aplicaciones clínicas, su uso puede estar asociado con efectos secundarios, incluyendo mielosupresión y trastornos gastrointestinales. La investigación en curso continúa explorando su potencial y optimizando su uso terapéutico en oncología.

Fórmula: C₂₉H₃₉NO₉

InChI: InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1

Clave InChI: InChIKey=HYFHYPWGAURHIV-JFIAXGOJSA-N

SMILES: O(C([C@@](CCCC(C)(C)O)(CC(OC)=O)O)=O)[C@H]1[C@@]2([C@@]3(N(CCC=4C2=CC5=C(C4)OCO5)CCC3)C=C1OC)[H]

Sinónimos:

• (4alpha)-O~3~-[2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
• Brn 5687925
• Ceflatonin
• Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate]
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI)
• Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI)
• Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
• Cgx-635
• Myelostat
• Nsc 141633
• Omacetaxine mepesuccinate
• Omacetaxine mepesuccinate [USAN]
• Omapro
• O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
• Synribo
• Unii-6Fg8041S5B

Omacetaxine Mepesuccinate (Homoharringtonine)

CAS: 26833-87-4

Fórmula: C₂₉H₃₉NO₉

Forma y color: White To Off-White Solid

Peso molecular: 545.63

Ref: 4Z-O-027001

Homoharringtonine

CAS: 26833-87-4

Fórmula: C₂₉H₃₉NO₉

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 545.62

Ref: 7W-GP6715

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine

Pureza: ≥98%

Peso molecular: 545.62g/mol

Ref: 54-BUP10774

Homoharringtonine

CAS: 26833-87-4

Fórmula: C₂₉H₃₉NO₉

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 545.63

Ref: 3B-H1775

Homoharringtonine

CAS: 26833-87-4

Fórmula: C₂₉H₃₉NO₉

Pureza: 95%~99%

Peso molecular: 545.629

Ref: BP-BP0732

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.

Fórmula: C₂₉H₃₉NO₉

Pureza: 98.21% - 99.91%

Forma y color: Off-White Cryst

Peso molecular: 545.62

Ref: TM-T3380

Homoharringtonine

CAS: 26833-87-4

Natural alkaloid

Fórmula: C₂₉H₃₉NO₉

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 545.63

Ref: 5G-89708

Homoharringtonine

Producto controlado

CAS: 26833-87-4

Applications Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal cells. HHT was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of α-ketoester harringtonine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Baaske, D., et al.: Antimicrob. Agents Chemother., 12, 298 (1977), Tipping, A., et al.: Leukemia, 16, 2349 (2002), Marin, D., et al.: Cancer, 103, 1850 (2005), Levy, V., et al.: Br. J. Cancer, 95, 253 (2006), de Lavallade, H., et al.: Blood, 2779 (2007),

Fórmula: C₂₉H₃₉NO₉

Forma y color: Neat

Peso molecular: 545.62

Ref: TR-H596500

Homoharringtonine

CAS: 26833-87-4

Homoharringtonine is an alkaloid isolated as an anticancer agent, which is derived from the Cephalotaxus genus of evergreen trees and shrubs. It is specifically extracted from the leaves and bark, traditionally known for its therapeutic applications in Chinese medicine. The mode of action of Homoharringtonine involves the inhibition of protein synthesis. It achieves this by binding to the A-site of the ribosomal subunit, impeding the elongation phase of protein synthesis and thus disrupting cellular proliferation.

Fórmula: C₂₉H₃₉NO₉

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 545.62 g/mol

Ref: 3D-FH15974

Homoharringtonine - Bio-X ™

CAS: 26833-87-4

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₉H₃₉NO₉

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 545.62 g/mol

Ref: 3D-BH300085

Homoharringtonine

CAS: 26833-87-4

Pureza: 99%

Peso molecular: 545.629

Ref: 10-F979707