CAS 27215-14-1

Neoandrographólido

Descripción:

Neoandrographólido es un compuesto natural derivado de la planta Andrographis paniculata, conocido comúnmente por sus propiedades medicinales. Pertenece a la clase de los diterpenoides y se caracteriza por su compleja estructura bicíclica, que contribuye a su actividad biológica. Este compuesto exhibe una variedad de efectos farmacológicos, incluyendo propiedades antiinflamatorias, antioxidantes y antimicrobianas. Neoandrographólido ha sido estudiado por sus posibles aplicaciones terapéuticas, particularmente en el tratamiento de diversas enfermedades, incluidas infecciones y condiciones inflamatorias. Su mecanismo de acción a menudo implica la modulación de vías de señalización y la inhibición de citoquinas proinflamatorias. Además, se sabe que posee efectos hepatoprotectores, lo que lo convierte en un tema de interés en la investigación sobre la salud del hígado. El compuesto se extrae típicamente de las hojas de la planta Andrographis y puede ser analizado utilizando diversas técnicas como cromatografía y espectroscopia para confirmar su pureza y concentración. En general, Neoandrographólido representa un área significativa de interés en la química de productos naturales y la farmacología debido a sus diversas actividades biológicas y posibles beneficios para la salud.

Fórmula: C₂₆H₄₀O₈

InChI: InChI=1/C26H40O8/c1-15-5-8-19-25(2,14-33-24-22(30)21(29)20(28)18(13-27)34-24)10-4-11-26(19,3)17(15)7-6-16-9-12-32-23(16)31/h9,17-22,24,27-30H,1,4-8,10-14H2,2-3H3/t17-,18-,19-,20-,21+,22-,24-,25+,26+/m1/s1

Clave InChI: InChIKey=YGCYRQKJYWQXHG-RDNQFMDVSA-N

SMILES: C[C@]12[C@@]([C@@](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)CCC1)(CCC(=C)[C@H]2CCC=4C(=O)OCC4)[H]

Sinónimos:

• (5S,6S,10R)-17-(beta-D-glucopyranosyloxy)-20-oxo-9,19-didehydro-5,6,7,8,9,10,11,12,15-decahydro-20:5,10-dicycloretinal
• 2(5H)-Furanone, 3-[2-[(1R,4aS,5R,8aS)-5-[(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-
• 2(5H)-Furanone, 3-[2-[5-[(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-, [1R-(1α,4aβ,5α,8aα)]-
• 3-[2-[(1R,4aS,5R,8aS)-5-[(β-<span class="text-smallcaps">D</span>-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• 3-[2-[(4aS,5R,8aS)-5,8a-Dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-5H-furan-2-one
• 5β,9β<span class="text-smallcaps">H</span>,10α-Labda-8(20),13-dien-16-oic acid, 18-(glucosyloxy)-15-hydroxy-, γ-lactone
• Neoandrographiside
• {(1R,4aS,8aS)-1,4a-dimethyl-6-methylidene-5-[2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl]decahydronaphthalen-1-yl}methyl beta-D-glucopyranoside
• 2(5H)-Furanone, 3-[2-[5-[(β-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-, [1R-(1α,4aβ,5α,8aα)]-
• 5β,9βH,10α-Labda-8(20),13-dien-16-oic acid, 18-(glucosyloxy)-15-hydroxy-, γ-lactone
• 2(5H)-Furanone, 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-
• 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• Neoandrographolide
• Neoandrographolide (Neoandrographiside)
• 3-(2-((1S,4aS,5R,8aS)-5,8a-Dimethyl-2-methylene-5-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)methyl)-decahydronaphthalen-1-yl)ethyl)furan-2(5H)-one
• Andrographolide Impurity 7
• 19-hydroxy-8(17),13-laboiadien-16,15-olide-o-βD-glucopyranoside
• ANDROGRAPHOLIDE, NEO(P)
• 3-[2-[(1R,4aβ)-5α-[(β-D-Glucopyranosyloxy)methyl]decahydro-5,8aα-dimethyl-2-methylenenaphthalen-1α-yl]ethyl]furan-2(5H)-one
• 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-Glucopyranosyloxy)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-5,8a-dimethyl-2-methylenenaphthalene-1-yl]ethyl]-2(5H)-furanone
• D-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• ANDROGRAPHOLIDE, NEO-
• ent-19-Hydroxy-8(17),13-labdadien-16,15-olide 19-O-β-D-glucopyranoside
• ANDROGRAPHOLIDE, NEO(SH)
• Neoandrographolide USP/EP/BP
• 4-[2-[(4aS,5R,8aS)-5,8a-dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one

Neoandrographolide

CAS: 27215-14-1

Fórmula: C₂₆H₄₀O₈

Pureza: 98%

Forma y color: Solid

Peso molecular: 480.5910

Ref: IN-DA00BC02

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide

Pureza: ≥98%

Peso molecular: 480.59g/mol

Ref: 54-BUP07499

Neoandrographolide

CAS: 27215-14-1

Fórmula: C₂₆H₄₀O₈

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 480.59

Ref: 7W-GC5354

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide has antiradical, anti-inflammatory,and hypolipidemic effects, it protects the cardiovascular without significant liver damage. Neoandrographolide as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIAP)-overexpressing Jurkat cells, a model for chemoresistance.Neoandrographolide inhibits iNOS and COX-2 expression through inhibiting p38 MAPKs activation.

Fórmula: C₂₆H₄₀O₈

Pureza: 95%~99%

Peso molecular: 480.598

Ref: BP-BP0988

Neoandrographolide

CAS: 27215-14-1

Fórmula: C₂₆H₄₀O₈

Pureza: >98.0%(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 480.60

Ref: 3B-N1127

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide has hypolipidemic, cardio-protective, anti-inflammatory effects, and enhances chemo-sensitivity without major liver harm.

Fórmula: C₂₆H₄₀O₈

Pureza: 98.52% - 99.00%

Forma y color: Less Columnar Crystal Colorless Columnar Crystal

Peso molecular: 480.59

Ref: TM-T3884

Neoandrographolide

CAS: 27215-14-1

Natural glycoside

Fórmula: C₂₆H₄₀O₈

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 480.6

Ref: 5G-89740

Neoandrographolide

Producto controlado

CAS: 27215-14-1

Applications Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia.
References Jarukamjorn, K., et al.: J. Health Sci., 54, 370-381 (2008);

Fórmula: C₂₆H₄₀O₈

Forma y color: Neat

Peso molecular: 480.59

Ref: TR-N389913

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide is a diterpene compound that has been shown to have a significant cytotoxic effect on HL-60 cells. It also shows matrix effects in body formation and chemiluminescence. Neoandrographolide is extracted from the plant Andrographis paniculata, which belongs to the family Acanthaceae. This plant has been used historically as a medical herb in China and India for centuries. The extract of this plant has shown anti-inflammatory properties and can be used to treat infectious diseases such as bowel disease.

Fórmula: C₂₆H₄₀O₈

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 480.6 g/mol

Ref: 3D-MN11576

3-(2-((1R,4aS,5R,8aS)-5,8a-Dimethyl-2-methylene-5-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)decahydronaphthalen-1-yl)ethyl)furan-2(5H)-one

CAS: 27215-14-1

Pureza: 98%

Peso molecular: 480.5979919

Ref: 10-F870427