CAS 2753-30-2

Gedunina

Descripción:

Gedunina es un compuesto químico que ocurre de forma natural y se clasifica como un limonoide, derivado principalmente de las semillas del árbol de neem (Azadirachta indica). Es conocido por sus diversas actividades biológicas, incluyendo propiedades antipalúdicas, antifúngicas y anticancerígenas. Gedunina exhibe una estructura molecular compleja caracterizada por múltiples anillos y grupos funcionales, que contribuyen a sus efectos farmacológicos. El compuesto ha despertado interés en la química medicinal debido a sus posibles aplicaciones terapéuticas, particularmente en el desarrollo de nuevos agentes antipalúdicos. Además, el mecanismo de acción de Gedunina implica la inhibición de ciertas enzimas y vías críticas para la supervivencia de patógenos, lo que lo convierte en un tema de investigación en el campo del descubrimiento de fármacos. Su solubilidad y estabilidad en varios disolventes pueden variar, influyendo en su biodisponibilidad y eficacia. En general, Gedunina representa un área significativa de estudio para los investigadores que exploran productos naturales como fuentes de compuestos terapéuticos novedosos.

Fórmula: C₂₈H₃₄O₇

InChI: InChI=1S/C28H34O7/c1-15(29)33-20-13-18-24(2,3)19(30)8-10-25(18,4)17-7-11-26(5)21(16-9-12-32-14-16)34-23(31)22-28(26,35-22)27(17,20)6/h8-10,12,14,17-18,20-22H,7,11,13H2,1-6H3/t17-,18+,20-,21+,22-,25-,26+,27+,28-/m1/s1

Clave InChI: InChIKey=YJXDGWUNRYLINJ-BHAPSIHVSA-N

SMILES: C[C@]12[C@]34[C@](C)([C@@H](OC(=O)[C@]3(O4)[H])C=5C=COC5)CC[C@@]1([C@]6(C)[C@@](C[C@H]2OC(C)=O)(C(C)(C)C(=O)C=C6)[H])[H]

Sinónimos:

• Gedunin
• 16,17-Seco-24-nor-5α,13α,14β,17α-chola-1,20,22-trien-16-oic acid, 14,15β:21,23-diepoxy-7α,17-dihydroxy-4,4,8-trimethyl-3-oxo-, 16,17-lactone, acetate
• Oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione, 5-(acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyl-, (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-
• D-Homo-24-nor-17-oxachola-1,20,22-triene-3,16-dione, 7-(acetyloxy)-14,15:21,23-diepoxy-4,4,8-trimethyl-, (5α,7α,13α,14β,15β,17aα)-
• (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a-decahydro-4b,7,7,10a,12a-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione

Gedunin

CAS: 2753-30-2

Fórmula: C₂₈H₃₄O₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 482.5654

Ref: IN-DA00C4IP

Gedunin

CAS: 2753-30-2

Gedunin

Pureza: ≥98%

Peso molecular: 482.57g/mol

Ref: 54-BUP07233

Gedunin

CAS: 2753-30-2

Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.

Fórmula: C₂₈H₃₄O₇

Pureza: 99.64% - 99.68%

Forma y color: Solid

Peso molecular: 482.57

Ref: TM-T21883

Gedunin

CAS: 2753-30-2

Oxygen-heterocyclic compound

Fórmula: C₂₈H₃₄O₇

Pureza: ≥ 90.0 % (HPLC)

Peso molecular: 482.57

Ref: 5G-82370

Gedunin

Producto controlado

CAS: 2753-30-2

Stability Hygroscopic
Applications Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).
References 1. Uddin, Shaikh J., et al., 2007. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy research : PTR. 21(8): 757-61. PMID: 174505092. Lee, Sung-Eun., et al., 2008. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 15(6-7): 533-5. PMID: 179134823. Brandt, Gary E L., et al., 2008. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. Journal of medicinal chemistry. 51(20): 6495-502. PMID: 18816111

Fórmula: C₂₈H₃₄O₇

Forma y color: Neat

Peso molecular: 482.56

Ref: TR-G303503

Gedunin

CAS: 2753-30-2

Gedunin is a pentacyclic triterpenoid compound which is primarily found in the neem tree (Azadirachta indica) and other plants in the Meliaceae family.Gedunin works by inhibiting heat shock proteins (Hsp), which are involved in protein folding and stress responses in cells. It also triggers apoptosis in cancer cells and modulates inflammatory pathways to reduce inflammation.Gedunin is used for its anticancer, antimalarial, antibacterial, antifungal, anti-inflammatory, and neuroprotective properties. It has shown promise in inducing apoptosis in cancer cells, effectively combating malaria parasites, exhibiting antimicrobial properties, reducing inflammation, and potentially benefiting neurodegenerative diseases like Parkinson's.

Fórmula: C₂₈H₃₄O₇

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 482.57 g/mol

Ref: 3D-XG161760