CAS 27848-84-6
:Nicergolina
Descripción:
Nicergolina es un compuesto sintético clasificado como un derivado de ergolina, utilizado principalmente por sus propiedades neuroprotectoras y de mejora cognitiva. Se conoce por su capacidad para mejorar el flujo sanguíneo cerebral y aumentar la utilización de oxígeno en el cerebro, lo que lo hace beneficioso en el tratamiento de trastornos cognitivos asociados con el envejecimiento y problemas vasculares. Nicergolina exhibe una estructura compleja, con un sistema de anillos bicíclicos característico de las ergolinas, y generalmente se administra en forma de su sal mesilato. La sustancia es soluble en agua y presenta una lipofilia moderada, lo que le permite cruzar la barrera hematoencefálica de manera efectiva. Sus efectos farmacológicos se atribuyen a su acción como antagonista alfa-adrenérgico y modulador de receptores de serotonina, que contribuyen a sus efectos vasodilatadores. Nicergolina es generalmente bien tolerado, con un perfil de efectos secundarios que puede incluir mareos, trastornos gastrointestinales y dolor de cabeza. Debido a sus propiedades de mejora cognitiva, se ha explorado en diversos entornos clínicos, particularmente en el manejo de la demencia y otros deterioros cognitivos.
Fórmula:C24H26BrN3O3
InChI:InChI=1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1
Clave InChI:InChIKey=YSEXMKHXIOCEJA-FVFQAYNVSA-N
SMILES:O(C)[C@@]12C=3C=4C(C[C@]1(N(C)C[C@H](COC(=O)C=5C=C(Br)C=NC5)C2)[H])=CN(C)C4C=CC3
Sinónimos:- (+)-10-Methoxy-1,6-dimethylergoline-8-beta-methanol 5-bromonicotinate
- (10-Methoxy-1,6-Dimethylergolin-8-Yl)Methyl 5-Bromopyridine-3-Carboxylate
- (8β)-10-Methoxy-1,6-dimethylergoline-8-methanol-5-bromo-3-pyridinecarboxylate ester
- 1,6-Dimethyl-8β-(5-bromonicotinoyloxymethyl)-10α-methoxyergoline
- 1-Methyl-lumilysergol 8-(5-bromonicotinate) 10-methyl ether
- 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat)
- 10-Methoxy-1,6-dimethyl-ergolin-8-beta-methanol-(5-bromnicotinat) [German]
- 10-Methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyrindinecarboxylate (ester)
- 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate
- 10-Methoxy-1,6-dimethylergoline-8beta-methanol 5-bromonicotinate (ester)
- 8-beta-((5-Bromonicotinoyloxy)methyl)-1,6-dimethyl-10-alpha-methoxyergoline
- Brn 4828393
- Cergodum
- Circo-Maren
- Dilasenil
- Duracebrol
- Ergobel
- Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester)
- Ergoline-8-beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, (8beta)-, 5-bromo-3-pyridinecarboxylate (ester)
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)-
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8β)-
- Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 8-(5-bromo-3-pyridinecarboxylate), (8β)-
- Ergoline-8beta-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester) (8CI)
- Ergoline-8β-methanol, 10-methoxy-1,6-dimethyl-, 5-bromonicotinate (ester)
- Ergotop
- Fi 6714
- Indolo[4,3-fg]quinoline, ergoline-8-methanol deriv.
- MNE
- Memoq
- Nicergolent
- Nicergolin
- Nicergolin [German]
- Nicergolina
- Nicergolina [DCIT]
- Nicergoline [USAN:INN:BAN:JAN]
- Nicergolinum
- Nicergolinum [INN-Latin]
- Nicotergoline
- Nicotinic acid, 5-bromo-, (10-methoxy-1,6-dimethylergolin-8β-yl)methyl ester
- Nimergoline
- Nimergoline base
- Nsc 150531
- Rp 19651
- Sermion
- Ta 079
- Unii-Jcv8365Fwn
- Vasospan
- [(8Beta)-10-Methoxy-1,6-Dimethylergolin-6-Ium-8-Yl]Methyl 5-Bromopyridine-3-Carboxylate
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Encontrado 20 productos.
Nicergoline
CAS:Fórmula:C24H26BrN3O3Pureza:>98.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:484.39Nicergoline
CAS:Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline inhibits the vasoconstrictor effect of catecholamines by inhibiting the postsynaptic 1-adrenoceptors on vascular smooth muscle. This Thermo Scientific Chemicals brand product was originally part
Fórmula:C24H27BrN3O3Forma y color:White to yellow, Powder or granular powderPeso molecular:485.40NICERGOLINE FOR SYSTEM SUITABILITY CRS
CAS:NICERGOLINE FOR SYSTEM SUITABILITY CRSFórmula:C24H26BrN3O3Forma y color:PowderPeso molecular:484.3855NICERGOLINE FOR PEAK IDENTIFICATION CRS
CAS:NICERGOLINE FOR PEAK IDENTIFICATION CRSFórmula:C24H26BrN3O3Forma y color:PowderPeso molecular:484.3855Nicergoline
CAS:Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.Fórmula:C24H26BrN3O3Pureza:98% - 99.80%Forma y color:SolidPeso molecular:484.39Nicergoline-13C-d3
CAS:Fórmula:C2313CH23D3BrN3O3Forma y color:White To Off-White SolidPeso molecular:488.40Nicergoline
CAS:Fórmula:C24H26BrN3O3Pureza:98.5 - 102.0 % (anhydrous basis)Forma y color:White to off-white or light-yellow powderPeso molecular:484.39Nicergoline-d3
CAS:Producto controladoApplications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)Fórmula:C24D3H23BrN3O3Forma y color:NeatPeso molecular:487.404Nicergoline
CAS:Producto controladoApplications Nicergoline is a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia. Nicergoline has shown to protect cultured neurons against β-amyloid toxicity. Nicergoline protects against neuronal cell death induced by activated microglia and astrocytes through the inhibition of inflammatory mediators and the upregulation of neurotrophic factors by glial cells. Nicergoline is a drug used for age-dependent cognitive impairment and it protects cultured neurons against β-amyloid toxicity.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)Fórmula:C24H26BrN3O3Forma y color:White To Off-WhitePeso molecular:484.39Nicergoline - Bio-X ™
CAS:Nicergoline is an ergot derivative drug that is used for the treatment of any symptoms associated with cerebrovascular abnormalities. This drug works by inhibiting alpha-1 adrenoreceptors on vascular smooth muscles which results in peripheral vasodilation. Furthermore, this drug has been suggested to ameliorate cognitive deficits.Fórmula:C24H26BrN3O3Pureza:Min. 95%Forma y color:PowderPeso molecular:484.39 g/molNicergoline
CAS:α1-adrenoceptor antagonist; inhibitor of platelet aggregation; antioxidant
Fórmula:C24H26BrN3O3Pureza:Min. 95%Forma y color:White PowderPeso molecular:484.4 g/molNicergoline N-Dimer
CAS:Producto controladoFórmula:C47H48Br2N6O6Forma y color:NeatPeso molecular:952.73
