CAS 28575-34-0

acetil pepstatina

Descripción:

acetil pepstatina es un derivado de péptido sintético conocido por su papel como un potente inhibidor de las aspartic proteasas, particularmente la renina y la pepsina. Se caracteriza por su estructura, que incluye un grupo acetilo y una secuencia de aminoácidos que contribuyen a su actividad biológica. El compuesto se utiliza típicamente en investigaciones bioquímicas para estudiar las funciones de las proteasas y sus mecanismos de inhibición. acetil pepstatina exhibe alta especificidad por sus enzimas objetivo, lo que lo hace valioso en estudios farmacológicos y aplicaciones terapéuticas potenciales. Sus propiedades de solubilidad están influenciadas por la presencia del grupo acetilo, que puede mejorar su estabilidad y biodisponibilidad. Además, el compuesto se utiliza a menudo en el desarrollo de fármacos destinados a tratar condiciones relacionadas con la actividad proteasa desregulada. Las precauciones de seguridad y manejo son esenciales al trabajar con esta sustancia, como con muchos compuestos químicos, para mitigar cualquier peligro potencial asociado con su uso en entornos de laboratorio.

Fórmula: C₃₁H₅₇N₅O₉

InChI: InChI=1/C31H57N5O9/c1-15(2)11-21(35-30(44)28(18(7)8)36-31(45)27(17(5)6)33-20(10)37)23(38)13-25(40)32-19(9)29(43)34-22(12-16(3)4)24(39)14-26(41)42/h15-19,21-24,27-28,38-39H,11-14H2,1-10H3,(H,32,40)(H,33,37)(H,34,43)(H,35,44)(H,36,45)(H,41,42)/t19-,21-,22+,23-,24+,27-,28-/m1/s1

Sinónimos:

• Ac-Val-Val-Sta-Ala-Sta-OH
• (3S,4S)-4-[[(2R)-2-[[(3R,4R)-4-[[(2R)-2-[[(2R)-2-acetamido-3-methyl-butanoyl]amino]-3-methyl-butanoyl]amino]-3-hydroxy-6-methyl-heptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-heptanoic acid
• Acetyl-Pepstatin
• Aids-080613
• ACETYL-PEPSTATIN USP/EP/BP
• Acetyl-Pepstatin - CAS 28575-34-0 - Calbiochem
• N-Acetyl-Pepstatin
• PEPSTATIN, ACETYL-
• (3S,7S,11S,12S,14S,18S)-11-Acetoxy-14-carbamoyl-3-hydroxy-4,12-diisobutyl-18-isopropyl-7,15,22-trimethyl-6,9,17,20-tetraoxo-5,8,13,19-tetraazatricosan-1-oic acid
• N-ACETYL-VAL-VAL(3S,4S)-STA-ALA-(3S,4S)-STA
• AC-VAL-VAL-STA-ALA-STA
• Acetyl-Pepstatin Ac-Val-Val-Sta-Ala-Sta-OH
• Pepstatin A monoacetate (ester)
• AC-PEPSTATIN
• Aids080613
• Ac-Pepstain/AC-VAL-VAL-STA-ALA-STA
• AC-VAL-VAL-(3S,4S)-STA-ALA-(3S,4S)-STA-OH
• (3S,4S)-4-[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoic acid

L-Valinamide, N-(3-methyl-1-oxobutyl)-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3-methylbutyl]amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-, monoacetate (ester), [1S-[1R*,2R*,4[R*[R*(R*)]]]]- (9CI)

CAS: 28575-34-0

Fórmula: C₃₁H₅₇N₅O₉

Pureza: 95%

Peso molecular: 643.8124

Ref: IN-DA002VQ4

Acetyl pepstatin

CAS: 28575-34-0

Acetyl pepstatin

Fórmula: C₃₁H₅₇N₅O₉

Pureza: By hplc: >98% by area (Typical Value in Batch COA)

Forma y color: white powder

Peso molecular: 643.81g/mol

Ref: 54-BIMI7332

Acetyl-Pepstatin Ac-Val-Val-Sta-Ala-Sta-OH

CAS: 28575-34-0

Acetyl-Pepstatin is a protein data inhibitor that binds to the active site of enzymes, inhibiting their function. Acetyl-pepstatin has been shown to inhibit cathepsin D, chymotrypsin, and trypsin. It also inhibits the activity of proteases in the stomach and intestinal tract. Acetyl-Pepstatin is used as an anti-inflammatory drug for the treatment of chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF). The inhibition of these enzymes reduces inflammation by preventing the activation of inflammatory cytokines. It also prevents collagen from being degraded by proteases, which leads to decreased degradation of cartilage by chondrocytes. This drug's mechanism is similar to that of acetylsalicylic acid (aspirin), in that it inhibits prostaglandin synthesis.br>

Fórmula: C₃₁H₅₇N₅O₉

Pureza: Min. 95%

Peso molecular: 643.81 g/mol

Ref: 3D-FA111026

Acetylpepstatin

CAS: 28575-34-0

Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.

Fórmula: C₃₃H₆₁N₅O₁₁

Pureza: 98%

Forma y color: Solid

Peso molecular: 703.875

Ref: TM-T26552

Acetyl-Pepstatin

CAS: 28575-34-0

Acetyl-pepstatin is reported to be an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and of HIV-2 proteinase (Ki = 5 nM at pH 4.7). Ac-Val-Val-Sta-Ala-Sta also inhibits the P. falciparum aspartyl protease plasmepsin II, IC₅₀ 0.6 nM.

Fórmula: C₃₁H₅₇N₅O₉

Pureza: 97.8%

Forma y color: White Powder

Peso molecular: 643.82

Ref: 01-4015928