CAS 28822-58-4

3-Isobutil-1-metilxantina

Descripción:

3-Isobutil-1-metilxantina (CAS 28822-58-4) es un derivado de xantina que exhibe propiedades similares a la cafeína y la teobromina, actuando principalmente como un inhibidor de la fosfodiesterasa. Este compuesto se caracteriza por sus características estructurales, que incluyen un núcleo de xantina con grupos isobutil y metilo en posiciones específicas, contribuyendo a su actividad biológica. Es conocido por sus efectos estimulantes, mejorando la alerta y la función cognitiva, y a menudo se estudia por sus posibles aplicaciones terapéuticas en condiciones como el asma y otros trastornos respiratorios debido a sus propiedades broncodilatadoras. El compuesto es típicamente soluble en disolventes orgánicos y exhibe estabilidad moderada bajo condiciones de laboratorio estándar. Su perfil farmacológico incluye efectos sobre los receptores de adenosina, que juegan un papel crucial en varios procesos fisiológicos. Al igual que muchos derivados de xantina, también puede tener implicaciones en la investigación relacionada con los procesos metabólicos y la regulación de la energía. Se deben observar precauciones de seguridad y manejo, como con cualquier sustancia química, para mitigar posibles riesgos para la salud.

Fórmula: C₁₀H₁₄N₄O₂

InChI: InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)

Clave InChI: InChIKey=APIXJSLKIYYUKG-UHFFFAOYSA-N

SMILES: C(C(C)C)N1C2=C(C(=O)N(C)C1=O)NC=N2

Sinónimos:

• 1-Methyl-3-(2-methylpropyl)-2,3,6,9-tetrahydro-1H-purine-2,6-dione
• 1-Methyl-3-isobutylxanthine
• 1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-
• 3,7-Dihydro-3-isobutyl-1-methyl-1H-purin-2,6-dion
• 3,7-dihidro-3-isobutil-1-metil-1H-purina-2,6-diona
• 3,7-dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione
• 3,9-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
• 3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione
• 3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione
• 3-Isobutyl-1-methylxanthine
• IMX
• Ibmx
• Isobutylmethylxanthine
• Methylisobutylxanthine
• Nsc 165960
• Sc 2964
• Xanthine, 3-isobutyl-1-methyl-

3-Isobutyl-1-methylxanthine

CAS: 28822-58-4

3-Isobutyl-1-methylxanthine is used in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the gro

Fórmula: C₁₀H₁₄N₄O₂

Forma y color: Solid, White

Peso molecular: 222.25

Ref: 02-J64598

1H-Purine-2,6-dione, 3,9-dihydro-1-methyl-3-(2-methylpropyl)-

CAS: 28822-58-4

Fórmula: C₁₀H₁₄N₄O₂

Pureza: 99%

Forma y color: Solid

Peso molecular: 222.2438

Ref: IN-DA002WN3

3-Isobutyl-1-methylxanthine

CAS: 28822-58-4

Fórmula: C₁₀H₁₄N₄O₂

Pureza: ≥ 99.0%

Forma y color: White solid

Peso molecular: 222.24

Ref: 7W-GL2425

3-Isobutyl-1-Methylxanthine

CAS: 28822-58-4

3-Isobutyl-1-Methylxanthine

Pureza: 98%

Peso molecular: 222.24g/mol

Ref: 54-OR1011019

IBMX

CAS: 28822-58-4

IBMX

Pureza: ≥98%

Peso molecular: 222.24g/mol

Ref: 54-BUP15795

IBMX

CAS: 28822-58-4

IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM

Fórmula: C₁₀H₁₄N₄O₂

Pureza: 98% - >99.99%

Forma y color: Off-White

Peso molecular: 222.24

Ref: TM-T1713

IBMX

CAS: 28822-58-4

Fórmula: C₁₀H₁₄N₄O₂

Peso molecular: 222.25

Ref: 4Z-K-031077

3-Isobutyl-1-methylxanthine

CAS: 28822-58-4

Applications A nonspecific inhibitor of phosphodiesterases.
References Beavo., J.A., et al.: Mol. Pharmacol., 6, 597 (1970), Scamps, F., et al.: Eur. J. Pharmacol., 224, 119 (1993)

Fórmula: C₁₀H₁₄N₄O₂

Forma y color: Neat

Peso molecular: 222.24

Ref: TR-I785000

IBMX - Bio-X ™

Producto controlado

CAS: 28822-58-4

IBMX is a competitive non-selective phosphodiesterase inhibitor that raises cAMP and activates PKA. It also inhibits TNFα and leukotriene synthesis. This chemical compound reduces inflammation and is an adenosine receptor antagonist.

IBMX is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₀H₁₄N₄O₂

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 222.24 g/mol

Ref: 3D-BI164529

3-Isobutyl-1-methylxanthine

Producto controlado

CAS: 28822-58-4

A non-specific inhibitor of cAMP and cGMP phosphodiesterases (PDEs) with IC50 values between 2 and 50 µM. 2-isobutyl-1-methylxanthine (IBMX) has also been found to inhibit phenylephrine-induced 5-HT release by neuroendocrine epithelial cells and IBMX-mediated increase in cAMP and upregulation of Ca2+ channels promotes neuronal differentiation. Additionally IBMX stimulates secretion of thyroid hormones, resulting in cAMP-mediated activation of glycogenolysis and reduced glycogen storage.

Fórmula: C₁₀H₁₄N₄O₂

Forma y color: Slightly Yellow Powder

Peso molecular: 222.24 g/mol

Ref: 3D-FI24659

3-Isobutyl-1-methylxanthine

Producto controlado

CAS: 28822-58-4

A non-specific inhibitor of cAMP and cGMP phosphodiesterases (PDEs) with IC50 values between 2 and 50 µM. 2-Isobutyl-1-methylxanthine (IBMX) has also been found to inhibit phenylephrine-induced 5-HT release by neuroendocrine epithelial cells and IBMX-mediated increase in cAMP and upregulation of Ca2+ channels promotes neuronal differentiation. Additionally IBMX stimulates secretion of thyroid hormones, resulting in cAMP-mediated activation of glycogenolysis and reduced glycogen storage.

Fórmula: C₁₀H₁₄N₄O₂

Peso molecular: 222.24 g/mol

Ref: 3D-J-640140

IBMX

CAS: 28822-58-4

Fórmula: C₁₀H₁₄N₄O₂

Pureza: 98%

Forma y color: Solid, Light yellow powder

Peso molecular: 222.248

Ref: 10-M01902