CAS 290297-26-6

Netupitant

Descripción:

Netupitant es un antagonista selectivo del receptor neuroquinina-1 (NK1) que se utiliza principalmente en la prevención de náuseas y vómitos asociados con la quimioterapia. A menudo se combina con palonosetron, un antagonista del receptor 5-HT3, para mejorar su eficacia. La fórmula molecular de Netupitant indica que contiene átomos de carbono, hidrógeno, nitrógeno y oxígeno, reflejando su naturaleza orgánica. Este compuesto se caracteriza por su alta afinidad por el receptor NK1, que juega un papel crucial en la respuesta emética. Netupitant se administra típicamente por vía oral y se absorbe bien en el tracto gastrointestinal. Su farmacocinética muestra una vida media relativamente larga, lo que permite una dosificación una vez al día. La sustancia generalmente se tolera bien, con efectos secundarios comunes que incluyen fatiga, estreñimiento y dolor de cabeza. Debido a su mecanismo de acción, Netupitant es particularmente efectivo en el manejo de náuseas y vómitos inducidos por quimioterapia, lo que lo convierte en una opción terapéutica valiosa en entornos de oncología.

Fórmula: C₃₀H₃₂F₆N₄O

InChI: InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3

Clave InChI: InChIKey=WAXQNWCZJDTGBU-UHFFFAOYSA-N

SMILES: N(C(C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)(C)C=2C(=CC(=NC2)N3CCN(C)CC3)C4=C(C)C=CC=C4

Sinónimos:

• 2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-o-tolylpyridin-3-yl]-N-methylisobutyramide
• Benzeneacetamide, N,alpha,alpha-trimethyl-N-(4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl)-3,5-bis(trifluoromethyl)-
• Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-
• N,α,α-Trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)benzeneacetamide
• Netupitan
• Netupitant
• Ro 67-31898/000

Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-

CAS: 290297-26-6

Fórmula: C₃₀H₃₂F₆N₄O

Pureza: 99%

Forma y color: Solid

Peso molecular: 578.5917

Ref: IN-DA002V9C

Netupitant

CAS: 290297-26-6

Netupitant

Pureza: ≥98%

Peso molecular: 578.59g/mol

Ref: 54-BUP13389

2-(3,5-Bis(Trifluoromethyl)Phenyl)-N,2-Dimethyl-N-(6-(4-Methylpiperazin-1-Yl)-4-(O-Tolyl)Pyridin-3-Yl)Propanamide

CAS: 290297-26-6

2-(3,5-Bis(Trifluoromethyl)Phenyl)-N,2-Dimethyl-N-(6-(4-Methylpiperazin-1-Yl)-4-(O-Tolyl)Pyridin-3-Yl)Propanamide

Pureza: 99%

Peso molecular: 578.59g/mol

Ref: 54-PC109174

Netupitant

CAS: 290297-26-6

Fórmula: C₃₀H₃₂F₆N₄O

Forma y color: White To Off-White Solid

Peso molecular: 578.60

Ref: 4Z-N-075001

NETUPITANT

CAS: 290297-26-6

Pureza: 95%

Peso molecular: 578.60302734375

Ref: 10-F856948

Netupitant

CAS: 290297-26-6

Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).

Fórmula: C₃₀H₃₂F₆N₄O

Pureza: 99.43%

Forma y color: Solid

Peso molecular: 578.59

Ref: TM-T6905

Netupitant

Producto controlado

CAS: 290297-26-6

Applications Netupitant is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active.
References Hoffmann, T., et al.: Bioorg. Med. Chem. Lett., 16, 1362 (2006); Di Fabio, R., et al.: Bioorg. Med. Chem., 21, 6264 (2013)

Fórmula: C₃₀H₃₂F₆N₄O

Forma y color: Neat

Peso molecular: 578.59

Ref: TR-N390950

Netupitant

CAS: 290297-26-6

Netupitant is an antiemetic drug that is used to treat bowel disease. It has been shown in a two-way crossover study to have biological properties in the treatment of disease activity. Netupitant inhibits the neurokinin-1 receptor and matrix effect, which are responsible for the development of cancerous cells. The drug also has inhibitory properties on p-gp substrates and netupitant, which prevents it from being absorbed by the gastrointestinal tract. This allows netupitant to be transported through the blood-brain barrier into malignant brain tumours, where it can act as a cytotoxic agent.

Pureza: Min. 95%

Ref: 3D-FN103430