CAS 292633-16-0

Ac-Leu-Glu-His-Asp-AMC

Descripción:

Ac-Leu-Glu-His-Asp-AMC, con el número CAS 292633-16-0, es un péptido sintético que sirve como sustrato para diversas enzimas proteolíticas, particularmente en investigaciones y ensayos bioquímicos. Este compuesto se caracteriza por su secuencia de aminoácidos: leucina acetilada (Ac-Leu), ácido glutámico (Glu), histidina (His), ácido aspártico (Asp), seguido del grupo fluorogénico AMC (7-amino-4-metilcumarina). La acetilación en el N-terminal mejora su estabilidad y solubilidad, mientras que el grupo AMC permite la detección por fluorescencia tras la escisión por enzimas, lo que lo hace útil para estudiar la actividad de las proteasas. La estructura del péptido contribuye a su especificidad y reactividad, permitiendo a los investigadores investigar la cinética y los mecanismos en diversos contextos biológicos. Además, la presencia de cadenas laterales cargadas y polares en los aminoácidos influye en sus interacciones en solución, afectando su comportamiento general en ensayos bioquímicos.

Fórmula: C₃₃H₄₁N₇O₁₁

Sinónimos:

• L-a-Asparagine, N-acetyl-L-leucyl-L-a-glutamyl-L-histidyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

N-Acetyl-Leu-Glu-His-Asp-7-amino-4-methylcoumarin

CAS: 292633-16-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₃₃H₄₁N₇O₁₁

Peso molecular: 711.72

Ref: 02-J66335

Ac-LEHD-AMC

CAS: 292633-16-0

Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.

Fórmula: C₃₃H₄₁N₇O₁₁

Forma y color: Solid

Peso molecular: 711.729

Ref: TM-T36342

Ac-Leu-Glu-His-Asp-MCA

CAS: 292633-16-0

Ac-Leu-Glu-His-Asp-MCA is a synthetic peptide that is used as a research tool. The peptide has been shown to bind to the alpha subunit of the nicotinic acetylcholine receptor, which is responsible for binding acetylcholine and transmitting nerve impulses. Ac-Leu-Glu-His-Asp-MCA activates the receptor by mimicking the effects of acetylcholine. Acetylcholine binding to the alpha subunit causes an influx of sodium ions into the cell, which leads to depolarization and an action potential. This synthetic peptide also binds to other types of receptors, including those for serotonin, dopamine, and adrenaline. Acetylcholine binding to these receptors leads to neurotransmitter release.

Fórmula: C₃₃H₄₁N₇O₁₁

Pureza: Min. 95%

Peso molecular: 711.72 g/mol

Ref: 3D-MCA-3198-V

Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt

CAS: 292633-16-0

Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt is a synthetic peptide that is derived from the amino acid sequence of caspases. Ac-Leu-Glu-His-Asp-AMC trifluoroacetate salt induces apoptosis in insect and E. coli cells by protease activity, which leads to cell death. The sequence of this peptide is found in Drosophila melanogaster and has been shown to induce apoptosis in insect cells. Caspases are enzymes that regulate apoptosis and play a key role in cell death.

Fórmula: C₃₃H₄₁N₇O₁₁

Pureza: Min. 95%

Peso molecular: 711.72 g/mol

Ref: 3D-FA110585