CAS 2955-27-3

ácido ursodesoxicólico

Descripción:

ácido ursodesoxicólico, también conocido como ácido ursodeoxicólico (UDCA), es un ácido biliar que se deriva del metabolismo del colesterol. Se caracteriza por sus propiedades hidrofílicas, que le permiten reducir la solubilidad del colesterol en la bilis, ayudando así a prevenir la formación de cálculos biliares de colesterol. La estructura química de ácido ursodesoxicólico presenta una disposición única de grupos hidroxilo, lo que contribuye a su capacidad para interactuar con las membranas celulares e influir en varios procesos fisiológicos. Se utiliza comúnmente en entornos clínicos para el tratamiento de ciertas enfermedades hepáticas, como la colangitis biliar primaria, y es conocido por sus efectos hepatoprotectores. Además, se ha estudiado ácido ursodesoxicólico por sus posibles beneficios en la mejora de la sensibilidad a la insulina y su papel en la modulación de la microbiota intestinal. Su perfil de seguridad es generalmente favorable, lo que lo convierte en un agente terapéutico valioso en el manejo de trastornos hepáticos colestásicos.

Fórmula: C₂₄H₄₀O₅

InChI: InChI=1/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19+,20+,22+,23+,24-/m1/s1

Clave InChI: InChIKey=BHQCQFFYRZLCQQ-UTLSPDKDSA-N

SMILES: O[C@@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCC(O)=O)C)(CC3)[H])[C@@H](O)C[C@@]2([C@]4(C)[C@](C1)(C[C@H](O)CC4)[H])[H])[H])[H]

Sinónimos:

• Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7β,12α)-
• (3α,5β,7β,12α)-3,7,12-Trihydroxycholan-24-oic acid
• 5β-Cholan-24-oic acid, 3α,7β,12α-trihydroxy-
• 7-Epicholic acid
• 5β-Cholanic acid, 3α,7β,12α-trihydroxy-
• Ursocholate
• 4-[(5S,7S,8S,10S,13R,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid USP/EP/BP
• Chenodeoxycholic Acid Impurity 4
• Ursodeoxycholic Acid EP Impurity D
• Ursodeoxycholic Acid Impurity 4（Ursodeoxycholic Acid EP Impurity D）
• Chenodeoxycholic Acid EP Impurity D
• 4-[(5S,7S,8S,10S,13R,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• Ursodeoxycholic Acid EP Impurity D/Ursocholic Acid/(R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
• 7β-Hydroxyisocholic Acid
• Ursodiol Impurity D
• Ursocholic Acid (Chenodeoxycholic Acid EP Impurity D, Ursodeoxycholic Acid EP Impurity D)
• Ursocholic acid
• (4R)-4-((3R,5S,7S,8R,9S,10S,12S,13R,14S)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7β,12α)-

CAS: 2955-27-3

Fórmula: C₂₄H₄₀O₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 408.5714

Ref: IN-DA002YQ7

Ursocholic Acid (Chenodeoxycholic Acid EP Impurity D, Ursodeoxycholic Acid EP Impurity D)

CAS: 2955-27-3

Fórmula: C₂₄H₄₀O₅

Forma y color: White To Off-White Solid

Peso molecular: 408.58

Ref: 4Z-C-5717

Ursocholic acid

CAS: 2955-27-3

Ursocholic acid

Pureza: ≥95%

Peso molecular: 408.57g/mol

Ref: 54-BUP08071

Ursocholic acid

CAS: 2955-27-3

Ursocholic acid, a bile acid found predominantly in bile of mammals.

Fórmula: C₂₄H₄₀O₅

Pureza: 98.89% - 99.62%

Forma y color: Solid

Peso molecular: 408.57

Ref: TM-T7331

Chenodeoxycholic Acid EP Impurity D

CAS: 2955-27-3

Fórmula: C₂₄H₄₀O₅

Peso molecular: 408.57

Ref: ST-EA-CP-C93004

Ursodeoxycholic Acid EP Impurity D

CAS: 2955-27-3

Fórmula: C₂₄H₄₀O₅

Peso molecular: 408.58

Ref: ST-EA-CP-U1004

Ursocholic Acid

Producto controlado

CAS: 2955-27-3

Impurity Ursodeoxycholic Acid EP Impurity D
Applications Ursocholic Acid (Ursodeoxycholic Acid EP Impurity D) is an Ursodeoxycholic Acid (U850000) impurity.
References Ward, A., et al.: Drugs, 1984, 27, 95 (1984), Sama, C., et al.: Clin. Drug Invest., 13, 192 (1997), Nobilis, M., et al.: J. Pharm. Biomed. Anal., 24, 937 (2001),

Fórmula: C₂₄H₄₀O₅

Forma y color: White To Beige

Peso molecular: 408.57

Ref: TR-U849900

Ursocholic acid

Producto controlado

CAS: 2955-27-3

Ursocholic acid is a bile acid that is used in the treatment of pediatric bowel disease. Ursocholic acid reduces the formation of cholesterol gallstones and its use has been shown to improve the symptoms of congestive heart failure. The mechanism of action for ursocholic acid is not fully understood but it has been shown to increase the amount of serum bile acids and reduce the amount of hydroxyl group in bile acids. Ursocholic acid also increases cell lysis by interacting with hydrophobic regions on the surface of cells. There are high concentrations of ursocholic acid found in human feces, which may be due to its hydrophobic effect. Ursocholic acid also inhibits HIV infection by binding to gp120, preventing gp120 from binding to CD4 receptors on T-cells.

Fórmula: C₂₄H₄₀O₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 408.57 g/mol

Ref: 3D-FU28645