CAS 29741-09-1

Apigenina 7-O-glucurónido

Descripción:

Apigenina 7-O-glucurónido es un glucósido flavonoide, específicamente un derivado glucurónido de la apigenina, que es un flavonoide que se encuentra de forma natural en varias plantas, incluyendo el perejil, la manzanilla y el apio. Este compuesto se caracteriza por su grupo ácido glucurónico unido al grupo hidroxilo en la posición 7 de la estructura de la apigenina. Exhibe diversas actividades biológicas, incluyendo propiedades antioxidantes, antiinflamatorias y potenciales anticancerígenas, lo que lo convierte en un tema de interés en la investigación farmacológica. Apigenina 7-O-glucurónido es soluble en agua debido a su grupo glucurónido, que mejora su biodisponibilidad en comparación con su forma aglicona. El compuesto se estudia a menudo por su papel en el metabolismo de las plantas y sus efectos en la salud humana, particularmente en relación con la ingesta dietética de flavonoides. Su estabilidad y reactividad pueden verse influenciadas por factores como el pH y la temperatura, que son consideraciones importantes tanto en contextos naturales como sintéticos. En general, Apigenina 7-O-glucurónido representa un área significativa de interés en el estudio de los fitoquímicos y sus beneficios para la salud.

Fórmula: C₂₁H₁₈O₁₁

InChI: InChI=1S/C21H18O11/c22-9-3-1-8(2-4-9)13-7-12(24)15-11(23)5-10(6-14(15)31-13)30-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21-23,25-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1

Clave InChI: InChIKey=JBFOLLJCGUCDQP-ZFORQUDYSA-N

SMILES: O=C1C=2C(OC(=C1)C3=CC=C(O)C=C3)=CC(O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O)=CC2O

Sinónimos:

• 4H-1-benzopyran-4-one, 7-(beta-D-glucopyranuronosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
• Apigenin 7-O-glucuronide
• Apigenin 7-O-β-<span class="text-smallcaps">D</span>-glucuronide
• Apigenin 7-O-β-<span class="text-smallcaps">D</span>-glucuronopyranoside
• Apigenin 7-O-β-glucuronide
• Apigenin 7-glucuronide
• Apigenin 7-β-glucuronide
• Apigenin-7-O-β-D glucuronoside
• Glucopyranosiduronic acid, 5-hydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, β-<span class="text-smallcaps">D</span>-
• Scutellarin A
• β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl
• 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid
• β-D-Glucopyranosiduronic acid, 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl

Apigenin-7-O-glucuronide

CAS: 29741-09-1

Apigenin-7-O-glucuronide analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₂₁H₁₈O₁₁

Pureza: (HPLC) ≥98%

Forma y color: Powder

Peso molecular: 446.37

Ref: 11-1465S

β-D-Glucopyranosiduronic acid, 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl

CAS: 29741-09-1

Fórmula: C₂₁H₁₈O₁₁

Pureza: 98%

Forma y color: Solid

Peso molecular: 446.3610

Ref: IN-DA002Z99

Apigenin-7-glucuronide

CAS: 29741-09-1

Apigenin-7-glucuronide

Pureza: ≥95%

Peso molecular: 446.36g/mol

Ref: 54-BUP04678

Apigenin 7-O-Glucuronide

CAS: 29741-09-1

Fórmula: C₂₁H₁₈O₁₁

Peso molecular: 446.36

Ref: 4Z-A-743

Apigenin-7-Glucuronide

CAS: 29741-09-1

Apigenin-7-Glucuronide

Pureza: 98+%

Peso molecular: 446.36g/mol

Ref: 54-OR1024405

Apigenin 7-O-Glucuronide-d4

CAS: 29741-09-1

Fórmula: C₂₁H₁₄D₄O₁₁

Peso molecular: 450.39

Ref: 4Z-A-749

Apigenin-7-O-glucuronide

CAS: 29741-09-1

Apigenin 7-O-β-D-glucuronide(AG), an active flavonoid derivative isolated from the agricultural residue of Juglans sigillata fruit husks, possesses multiple pharmacological activities, including anti-oxidant, anti-complement, and aldose reductase inhibitory activities; AG protects mice from LPS-induced endotoxin shock by inhibiting proinflammatory cytokine production, suggests that AG may be used as a source of anti-inflammatory agents as well as a dietary complement for health promotion.

Fórmula: C₂₁H₁₈O₁₁

Pureza: 95%~99%

Forma y color: Yellow powder

Peso molecular: 446.364

Ref: BP-BP0179

Apigenin-d5 7-O-Glucuronide

CAS: 29741-09-1

Fórmula: C₂₁H₁₃D₅O₁₁

Peso molecular: 451.39

Ref: 4Z-A-745

Apigenin-7-glucuronide

CAS: 29741-09-1

Apigenin-7-glucuronide: antioxidant, anti-inflammatory, inhibits MMP-3/8/9/13 (IC50: 12.87/22.39/17.52/0.27 μM).

Fórmula: C₂₁H₁₈O₁₁

Pureza: 99.27% - 99.59%

Forma y color: Solid

Peso molecular: 446.36

Ref: TM-T5S1026

Apigenin 7-glucuronide

CAS: 29741-09-1

Fórmula: C₂₁H₁₈O₁₁

Pureza: ≥ 95.0%

Forma y color: Yellow powder

Peso molecular: 446.36

Ref: 7W-GL6788

Apigenin 7-glucuronide

CAS: 29741-09-1

Natural glycoside

Fórmula: C₂₁H₁₈O₁₁

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 446.37

Ref: 5G-83471

Apigenin 7-Glucuronide

CAS: 29741-09-1

Applications Apigenin 7-Glucuronide is a metabolite of Apigenin, which induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells.
References Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994), Sato, F., et al.: Biochem. Biophys. Res. Commun., 204, 578 (1994), Kuo, M.L. et al.: Biochem. Biophys. Res. Commun., 212, 767 (1995)

Fórmula: C₂₁H₁₈O₁₁

Forma y color: Neat

Peso molecular: 446.36

Ref: TR-A726505

Apigenin-7-O-glucronide

CAS: 29741-09-1

Apigenin-7-O-glucronide is a flavonoid derivative, which is a bioactive compound found naturally in various plants, particularly in those used medicinally or as nutritional supplements. Its source includes a variety of plant species, where it exists as part of the plant's secondary metabolites, often contributing to the plant's defense mechanisms.

Fórmula: C₂₁H₁₈O₁₁

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 446.36 g/mol

Ref: 3D-MA74543

Apigenin-d5 7-Glucuronide

Producto controlado

CAS: 29741-09-1

Fórmula: C₂₁H₁₃D₅O₁₁

Forma y color: Neat

Peso molecular: 451.39

Ref: TR-A726507

Apigenin 7-O-Glucuronide

CAS: 29741-09-1

Fórmula: C₂₁H₁₈O₁₁

Peso molecular: 446.36

Ref: ST-EA-CP-A205004